Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

• Published in: Molecular cell Vol. 73; no. 4; pp. 684 - 698.e8
• Main Authors: Sen, Payel, Lan, Yemin, Li, Catherine Y., Sidoli, Simone, Donahue, Greg, Dou, Zhixun, Frederick, Brian, Chen, Qijun, Luense, Lacey J., Garcia, Benjamin A., Dang, Weiwei, Johnson, F. Bradley, Adams, Peter D., Schultz, David C., Berger, Shelley L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2019
• Subjects: Acetylation; Cell Proliferation - genetics; Cellular Senescence - genetics; chromatin; Chromatin - enzymology; Chromatin - genetics; Chromatin Assembly and Disassembly - genetics; enhancers; Epigenetic Repression; epigenetics; Fibroblasts - enzymology; HEK293 Cells; High-Throughput Nucleotide Sequencing - methods; Histones - genetics; Histones - metabolism; Humans; p300; p300-CBP Transcription Factors - genetics; p300-CBP Transcription Factors - metabolism; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; senescence; Signal Transduction; Time Factors; Transcription, Genetic; senescence; p300; enhancers; chromatin; epigenetics

Accumulation of senescent cells during aging contributes to chronic inflammation and age-related diseases. While senescence is associated with profound alterations of the epigenome, a systematic view of epigenetic factors in regulating senescence is lacking. Here, we curated a library of short hairp...