Hydrogen tunneling links protein dynamics to enzyme catalysis

• Published in: Annual review of biochemistry Vol. 82; p. 471
• Main Authors: Klinman, Judith P, Kohen, Amnon
• Format: Journal Article
• Language: English
• Published: United States 01.01.2013
• Subjects: Catalysis; Enzymes - chemistry; Enzymes - physiology; Hydrogen - chemistry; Hydrogen - metabolism; Hydrogen - physiology; Kinetics; Models, Molecular; Protein Conformation; Proteins - chemistry; Proteins - physiology; Thermodynamics

The relationship between protein dynamics and function is a subject of considerable contemporary interest. Although protein motions are frequently observed during ligand binding and release steps, the contribution of protein motions to the catalysis of bond making/breaking processes is more difficul...