miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin α5 Expression

• Published in: The American journal of pathology Vol. 182; no. 5; pp. 1876 - 1889
• Main Authors: Ohyagi-Hara, Chifumi, Sawada, Kenjiro, Kamiura, Shoji, Tomita, Yasuhiko, Isobe, Aki, Hashimoto, Kae, Kinose, Yasuto, Mabuchi, Seiji, Hisamatsu, Takeshi, Takahashi, Toshifumi, Kumasawa, Keiichi, Nagata, Shigenori, Morishige, Ken-ichirou, Lengyel, Ernst, Kurachi, Hirohisa, Kimura, Tadashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2013
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Base Sequence; Biomarkers, Tumor - metabolism; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Integrin alpha5 - genetics; Integrin alpha5 - metabolism; Mice; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Staging; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Pathology; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - secondary; Prognosis; Protein Binding - genetics; Xenograft Model Antitumor Assays; Young Adult

Ovarian cancer is characterized by widespread peritoneal dissemination and ascites and has a cure rate of only 30%. As has been previously reported, integrin α5 plays a key role in the peritoneal dissemination of ovarian cancer. Our aim was to identify a new miRNA that regulates integrin α5 expressi...