Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be cate...
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Published in | Cell reports (Cambridge) Vol. 29; no. 3; pp. 573 - 588.e7 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
15.10.2019
Elsevier |
Subjects | |
Online Access | Get full text |
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