Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be cate...

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Bibliographic Details
Published inCell reports (Cambridge) Vol. 29; no. 3; pp. 573 - 588.e7
Main Authors Botton, Thomas, Talevich, Eric, Mishra, Vivek Kumar, Zhang, Tongwu, Shain, A. Hunter, Berquet, Céline, Gagnon, Alexander, Judson, Robert L., Ballotti, Robert, Ribas, Antoni, Herlyn, Meenhard, Rocchi, Stéphane, Brown, Kevin M., Hayward, Nicholas K., Yeh, Iwei, Bastian, Boris C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.10.2019
Elsevier
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