Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant, Methylmercury

• Published in: Toxics (Basel) Vol. 11; no. 9; p. 739
• Main Authors: Alshehri, Samiyah, Ahmad, Sheikh F., Albekairi, Norah A., Alqarni, Sana S., Al-Harbi, Naif O., Al-Ayadhi, Laila Y., Attia, Sabry M., Alfardan, Ali S., Bakheet, Saleh A., Nadeem, Ahmed
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.08.2023; MDPI
• Subjects: Analysis; Antioxidants; Autism; Body fluids; Children; Children & youth; Contaminants; Detoxification; Development and progression; Dimethylmercury; Environmental aspects; Environmental effects; Enzymes; Epigenetics; Exposure; Flow cytometry; Health aspects; Heavy metals; Immune system; Kinases; Leukocytes (neutrophilic); Lymphocytes; Mercury; Mercury (metal); Mercury compounds; Methylmercury; Neutrophils; Nitrotyrosine; Oxidants; Oxidative stress; Oxidizing agents; Pathogenesis; Pervasive developmental disorders; Proteins; Reductases; Risk factors; Sulforaphane; Thioredoxin; thioredoxin 1; Toxicants; Transcription factors; Saudi Arabia; United States > US; Riyadh Saudi Arabia

Autism spectrum disorder (ASD) is a complex developmental disorder in children that results in abnormal communicative and verbal behaviors. Exposure to heavy metals plays a significant role in the pathogenesis or progression of ASD. Mercury compounds pose significant risk for the development of ASD...