Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways

• Published in: Molecular metabolism (Germany) Vol. 60; p. 101492
• Main Authors: Lautherbach, Natalia, Gonçalves, Dawit A.P., Silveira, Wilian A., Paula-Gomes, Sílvia, Valentim, Rafael Rossi, Zanon, Neusa M., Pereira, Marcelo G., Miyabara, Elen H., Navegantes, Luiz C.C., Kettelhut, Isis C.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.06.2022; Elsevier
• Subjects: Adrenocorticotropic Hormone - metabolism; Adrenocorticotropic Hormone - pharmacology; Animals; cAMP; Corticotropin-Releasing Hormone - metabolism; Fatigue resistance; Hypertrophy; Hypertrophy - metabolism; Insulin - metabolism; Insulin-Like Growth Factor I - metabolism; Mice; Muscle, Skeletal - metabolism; Original; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; Urocortin 2; Urocortins - metabolism; Urocortins - pharmacology; Fatigue resistance; Urocortin 2; cAMP; Hypertrophy

Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle ma...