Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways
Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle ma...
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Published in | Molecular metabolism (Germany) Vol. 60; p. 101492 |
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Language | English |
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Abstract | Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle mass and protein metabolism remains elusive.
To elucidate the mechanisms how Ucn2 directly controls protein metabolism in skeletal muscles of normal mice, we carried out genetic tools, physiological and molecular analyses of muscles in vivo and in vitro.
Here, we demonstrated that Ucn2 overexpression activated cAMP signaling and promoted an expressive muscle hypertrophy associated with higher rates of protein synthesis and activation of Akt/mTOR and ERK1/2 signaling pathways. Furthermore, Ucn2 induced a decrease in mRNA levels of atrogin-1 and in autophagic flux inferred by an increase in the protein content of LC3-I, LC3-II and p62. Accordingly, Ucn2 reduced both the transcriptional activity of FoxO in vivo and the overall protein degradation in vitro through an inhibition of lysosomal proteolytic activity. In addition, we demonstrated that Ucn2 induced a fast-to-slow fiber type shift and improved fatigue muscle resistance, an effect that was completely blocked in muscles co-transfected with mitogen-activated protein kinase phosphatase 1 (MKP-1), but not with dominant-negative Akt mutant (Aktmt).
These data suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle of normal mice probably through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling. These findings open new perspectives in the development of therapeutic strategies to cope with the loss of muscle mass.
•Ucn2 overexpression promotes muscle growth due to an increase in protein synthesis.•Ucn2 inhibits FoxO activity and autophagic-lysosomal system.•Ucn2-induced skeletal muscle phenotype is dependent on Akt and ERK1/2.•Ucn2 induces a fast-to-slow fiber type shift and improves fatigue resistance.•The increase in muscle fatigue resistance is dependent on ERK1/2. |
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AbstractList | Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle mass and protein metabolism remains elusive.
To elucidate the mechanisms how Ucn2 directly controls protein metabolism in skeletal muscles of normal mice, we carried out genetic tools, physiological and molecular analyses of muscles in vivo and in vitro.
Here, we demonstrated that Ucn2 overexpression activated cAMP signaling and promoted an expressive muscle hypertrophy associated with higher rates of protein synthesis and activation of Akt/mTOR and ERK1/2 signaling pathways. Furthermore, Ucn2 induced a decrease in mRNA levels of atrogin-1 and in autophagic flux inferred by an increase in the protein content of LC3-I, LC3-II and p62. Accordingly, Ucn2 reduced both the transcriptional activity of FoxO in vivo and the overall protein degradation in vitro through an inhibition of lysosomal proteolytic activity. In addition, we demonstrated that Ucn2 induced a fast-to-slow fiber type shift and improved fatigue muscle resistance, an effect that was completely blocked in muscles co-transfected with mitogen-activated protein kinase phosphatase 1 (MKP-1), but not with dominant-negative Akt mutant (Aktmt).
These data suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle of normal mice probably through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling. These findings open new perspectives in the development of therapeutic strategies to cope with the loss of muscle mass. Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle mass and protein metabolism remains elusive. To elucidate the mechanisms how Ucn2 directly controls protein metabolism in skeletal muscles of normal mice, we carried out genetic tools, physiological and molecular analyses of muscles in vivo and in vitro. Here, we demonstrated that Ucn2 overexpression activated cAMP signaling and promoted an expressive muscle hypertrophy associated with higher rates of protein synthesis and activation of Akt/mTOR and ERK1/2 signaling pathways. Furthermore, Ucn2 induced a decrease in mRNA levels of atrogin-1 and in autophagic flux inferred by an increase in the protein content of LC3-I, LC3-II and p62. Accordingly, Ucn2 reduced both the transcriptional activity of FoxO in vivo and the overall protein degradation in vitro through an inhibition of lysosomal proteolytic activity. In addition, we demonstrated that Ucn2 induced a fast-to-slow fiber type shift and improved fatigue muscle resistance, an effect that was completely blocked in muscles co-transfected with mitogen-activated protein kinase phosphatase 1 (MKP-1), but not with dominant-negative Akt mutant (Aktmt). These data suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle of normal mice probably through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling. These findings open new perspectives in the development of therapeutic strategies to cope with the loss of muscle mass. •Ucn2 overexpression promotes muscle growth due to an increase in protein synthesis.•Ucn2 inhibits FoxO activity and autophagic-lysosomal system.•Ucn2-induced skeletal muscle phenotype is dependent on Akt and ERK1/2.•Ucn2 induces a fast-to-slow fiber type shift and improves fatigue resistance.•The increase in muscle fatigue resistance is dependent on ERK1/2. • Ucn2 overexpression promotes muscle growth due to an increase in protein synthesis. • Ucn2 inhibits FoxO activity and autophagic-lysosomal system. • Ucn2-induced skeletal muscle phenotype is dependent on Akt and ERK1/2. • Ucn2 induces a fast-to-slow fiber type shift and improves fatigue resistance. • The increase in muscle fatigue resistance is dependent on ERK1/2. Objective: Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle mass and protein metabolism remains elusive. Methods: To elucidate the mechanisms how Ucn2 directly controls protein metabolism in skeletal muscles of normal mice, we carried out genetic tools, physiological and molecular analyses of muscles in vivo and in vitro. Results: Here, we demonstrated that Ucn2 overexpression activated cAMP signaling and promoted an expressive muscle hypertrophy associated with higher rates of protein synthesis and activation of Akt/mTOR and ERK1/2 signaling pathways. Furthermore, Ucn2 induced a decrease in mRNA levels of atrogin-1 and in autophagic flux inferred by an increase in the protein content of LC3-I, LC3-II and p62. Accordingly, Ucn2 reduced both the transcriptional activity of FoxO in vivo and the overall protein degradation in vitro through an inhibition of lysosomal proteolytic activity. In addition, we demonstrated that Ucn2 induced a fast-to-slow fiber type shift and improved fatigue muscle resistance, an effect that was completely blocked in muscles co-transfected with mitogen-activated protein kinase phosphatase 1 (MKP-1), but not with dominant-negative Akt mutant (Aktmt). Conclusions: These data suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle of normal mice probably through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling. These findings open new perspectives in the development of therapeutic strategies to cope with the loss of muscle mass. OBJECTIVEAlthough it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific corticotrophin-releasing factor 2 receptor (CRF2R) are highly expressed in skeletal muscle, the role of this peptide in the regulation of skeletal muscle mass and protein metabolism remains elusive. METHODSTo elucidate the mechanisms how Ucn2 directly controls protein metabolism in skeletal muscles of normal mice, we carried out genetic tools, physiological and molecular analyses of muscles in vivo and in vitro. RESULTSHere, we demonstrated that Ucn2 overexpression activated cAMP signaling and promoted an expressive muscle hypertrophy associated with higher rates of protein synthesis and activation of Akt/mTOR and ERK1/2 signaling pathways. Furthermore, Ucn2 induced a decrease in mRNA levels of atrogin-1 and in autophagic flux inferred by an increase in the protein content of LC3-I, LC3-II and p62. Accordingly, Ucn2 reduced both the transcriptional activity of FoxO in vivo and the overall protein degradation in vitro through an inhibition of lysosomal proteolytic activity. In addition, we demonstrated that Ucn2 induced a fast-to-slow fiber type shift and improved fatigue muscle resistance, an effect that was completely blocked in muscles co-transfected with mitogen-activated protein kinase phosphatase 1 (MKP-1), but not with dominant-negative Akt mutant (Aktmt). CONCLUSIONSThese data suggest that Ucn2 triggers an anabolic and anti-catabolic response in skeletal muscle of normal mice probably through the activation of cAMP cascade and participation of Akt and ERK1/2 signaling. These findings open new perspectives in the development of therapeutic strategies to cope with the loss of muscle mass. |
ArticleNumber | 101492 |
Author | Lautherbach, Natalia Gonçalves, Dawit A.P. Silveira, Wilian A. Miyabara, Elen H. Kettelhut, Isis C. Zanon, Neusa M. Navegantes, Luiz C.C. Paula-Gomes, Sílvia Valentim, Rafael Rossi Pereira, Marcelo G. |
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Cites_doi | 10.1016/S0006-2952(00)00429-9 10.1016/j.cellsig.2005.03.011 10.1073/pnas.92.3.836 10.1113/jphysiol.2003.056770 10.1073/pnas.0405659101 10.1038/74255 10.1038/87936 10.1002/jcsm.12746 10.1073/pnas.0307324101 10.1210/me.2010-0308 10.1016/S0021-9258(19)61974-5 10.1038/sj.bjp.0706669 10.1007/s11010-014-2213-1 10.1002/j.1460-2075.1996.tb01045.x 10.1016/S0092-8674(04)00115-1 10.1038/35093131 10.1038/embor.2008.163 10.1083/jcb.200507002 10.1097/SHK.0b013e31802e43a6 10.2337/db18-1237 10.1016/j.ajpath.2011.01.005 10.1210/en.2003-0271 10.1016/S0305-0491(98)10106-2 10.1152/ajpendo.00188.2011 10.1016/S0092-8674(04)00400-3 10.3945/ajcn.110.001917 10.1038/24884 10.1038/nrm3025 10.1152/ajpendo.2001.281.3.E449 10.1242/dmm.010389 10.1074/jbc.M403604200 10.1096/fj.10-168799 10.1159/000494655 10.1210/edrv-16-2-143 10.1371/journal.pone.0026581 10.1073/pnas.1013761107 10.4161/auto.6.7.12785 10.1074/jbc.M110856200 10.1073/pnas.1232352100 10.1002/jcsm.12395 10.1002/mus.20820 10.1016/j.cmet.2007.11.004 10.1016/S0092-8674(03)00929-2 10.1038/ncb1676 10.1124/jpet.114.217380 10.1038/sj.bjp.0705985 10.1152/ajpendo.00081.2003 10.1210/me.2014-1245 10.1128/MCB.25.11.4792-4803.2005 10.1096/fj.201902102RR 10.1016/j.mce.2009.09.028 10.1210/en.2012-2011 10.1161/01.RES.0000041029.97988.E9 10.1073/pnas.92.4.1108 10.1006/jmcc.2000.1135 10.1002/mus.22066 10.1172/JCI117929 10.1111/j.1749-6632.1999.tb08687.x 10.1038/35004013 10.1210/me.2003-0054 10.1038/ncb1101-1014 10.1083/jcb.200703195 10.1074/jbc.M702824200 10.1016/j.cmet.2007.11.001 10.1097/MCO.0b013e328360272d 10.1074/jbc.M114.589325 10.1016/S0022-2828(03)00244-X 10.1038/74263 10.1073/pnas.0607337103 10.1172/JCI83532 10.1073/pnas.0607795103 10.1152/ajpcell.00475.2008 10.1101/gad.1525107 10.1152/ajpendo.00147.2006 10.1002/2211-5463.12195 10.1093/emboj/19.23.6341 10.1152/ajpendo.2000.279.3.E663 10.1210/en.2003-1570 10.1152/japplphysiol.00065.2019 10.1152/ajpcell.00466.2006 10.1002/1097-4652(200101)186:1<104::AID-JCP1015>3.0.CO;2-0 10.1210/en.2003-0689 10.1007/s10974-004-4088-3 10.1038/nature00904 10.1038/21224 10.1371/journal.pone.0012345 |
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Keywords | Fatigue resistance Urocortin 2 cAMP Hypertrophy |
Language | English |
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References | Borg, Massart, Schönke, Barbosa, Guo, Wade (bib79) 2019; 68 Jones, Fedorov, Rosenthal (bib84) 2001; 186 Inoki, Zhu, Guan, Arbor (bib25) 2003; 115 Chen, Blount, Vaughan, Brar, Foundation, Biology (bib6) 2004; 145 de Rooij, Zwartkruis, Verheijen, Cool, Nijman, Wittinghofer (bib50) 1998; 396 Hinkle, Donnelly, Cody, Bauer, Isfort (bib14) 2003; 144 Hall, Kaczor, Hettinga (bib61) 2007; 36 Handschin, Rhee, Lin, Tarr, Spiegelman (bib74) 2003; 100 Navegantes, Resano, Migliorini, Kettelhut (bib67) 2001; 281 Hinkle, Donnelly, Cody, Bauer, Sheldon, Isfort (bib59) 2004; 25 Baviera, Zanon, Navegantes, Kettelhut (bib66) 2010; 315 Bueno, De Windt, Tymitz, Witt, Kimball, Klevitsky (bib86) 2000; 19 Brar, Jonassen, Egorina, Chen, Negro, Perrin (bib93) 2004; 145 Hinkle, Lefever, Dolan, Reichart, Dietrich, Gropp (bib90) 2007; 5 Ju, Varadhachary, Miller, Weihl (bib45) 2010; 6 Bjørkøy, Lamark, Brech, Outzen, Perander, Overvatn (bib54) 2005; 171 Singh, Simpson, Bennett (bib34) 2015; 290 Reutenauer-patte, Boittin, Patthey-vuadens, Ruegg, Dorchies (bib60) 2012; 180 Geng, Li, Yin, Yan (bib77) 2011; 178 Silveira, Gonçalves, Machado, Lautherbach, Lustrino, Marcelo (bib78) 2020; 34 Hinkle, Donnelly, Cody, Samuelsson, Lange, Bauer (bib15) 2003; 285 LeRoith, Werner, Beitner-Johnson, Roberts (bib22) 1995; 16 Mei, Qiao, Tsygankova, Meinkoth, Quilliam, Cheng (bib81) 2002; 277 Navegantes, Resano, Migliorini (bib68) 2000; 279 Borg, Massart, De Castro Barbosa, Archilla-Ortega, Smith, Lanner (bib16) 2021; 12 Milan, Romanello, Pescatore, Armani, Paik, Frasson (bib32) 2015; 6 Yokoyama, Takano, Yoshida, Katada, Sun, Takenawa (bib85) 2007; 177 Shi, Scheffler, Zeng, Pleitner, Hannon, Grant (bib88) 2009; 296 Jesinkey, Korrapati, Rasbach, Beeson, Schnellmann (bib62) 2014; 351 Roy, Srivastava, Shankar (bib28) 2010; 5 Bonaldo, Sandri (bib31) 2013; 6 Zoncu, Efeyan, Sabatini (bib51) 2011; 12 Lin, Wu, Tarr, Zhang, Wu, Boss (bib58) 2002; 418 Hsu, Hsueh (bib2) 2001; 7 Chao, Li, Grande, Lira, Yan, Harris (bib80) 2015; 29 Bodine, Stitt, Gonzalez, Kline, Stover, Bauerlein (bib24) 2001; 3 Ryall, Sillence, Lynch (bib69) 2006; 147 Murgia, Serrano, Calabria, Pallafacchina, Lomo, Schiaffino (bib37) 2000; 2 Ueyama, Kawashima, Sakoda, Rikitake, Ishida, Kawai (bib87) 2000; 32 Chen, Brar, Choi, Rousso, Vaughan, Kuperman (bib13) 2006; 103 Kishimoto, Ilt, Lin, Rosenfeldt (bib3) 1995; 92 Reyes, Lewis, Perrin, Kunitake, Vaughan, Arias (bib1) 2001; 98 Zhang, Yano, Deng, Mao, Shaw, Tseng (bib63) 2011; 6 Liu, Bordicchia, Zhang, Fang, Wei, Li (bib64) 2016; 126 Baviera, Zanon, Carvalho Navegantes, Migliorini, do Carmo Kettelhut (bib73) 2007; 292 Sandri, Lin, Handschin, Yang, Arany, Lecker (bib76) 2006; 103 Costelli, García-Martínez, Llovera, Carbó, López-Soriano, Agell (bib71) 1995; 95 Chen, Vaughan, Vale (bib9) 2003; 17 Sandri, Sandri, Gilbert, Skurk, Calabria, Picard (bib30) 2004; 117 Wang, Pessin (bib38) 2013; 16 Kelleher, Govindarajan, Jung, Kang, Tonegawa (bib57) 2004; 116 Yang, Tse, Hu, Jia, Du, Chan (bib36) 2018; 50 Perrin, Vale (bib5) 1999; 885 Miyazaki, Takemasa (bib26) 2017; 7 Vaughan, Donaldson, Fischer, Perrin, Rivier, Sawchenko (bib46) 2013; 154 Coste, Kesterson, Heldwein, Stevens, Heard, Hollis (bib7) 2000; 24 Myers, Grammer, Wang, Sun, Pierce, Blenis (bib23) 1994; 269 Mammucari, Milan, Romanello, Masiero, Rudolf, Del Piccolo (bib29) 2007; 6 Gao, Zhou, Wang, Lew, Richards, Wang (bib39) 2015; 398 Wu, Zhang, Bennett (bib48) 2005; 25 Geng, Klionsky (bib53) 2008; 9 Brennesvik, Ktori, Ruzzin, Jebens, Shepherd, Jensen (bib82) 2005; 17 Neufeld-Cohen, Tsoory, Evans, Getselter, Gil, Lowry (bib10) 2010; 107 Dimmeler, Fleming, Fisslthaler, Hermann, Busse, Zeiher (bib47) 1999; 399 Roux, Ballif, Anjum, Gygi, Blenis (bib92) 2004; 101 Yang, Zong, Xia, Yamaguchi, Ding, Xie (bib27) 2008; 10 Goodman, Mabrey, Frey, Miu, Schmidt, Pierre (bib44) 2011; 25 Bale, Contarino, Smith, Chan, Gold, Sawchenko (bib8) 2000; 24 Kuperman, Issler, Vaughan, Bilezikjian, Vale, Chen (bib17) 2011; 25 Butler, Yakar, Gewolb, Karas, Okubo, LeRoith (bib21) 1998; 121 Handschin, Kobayashi, Chin, Seale, Campbell, Spiegelman (bib35) 2007; 21 Pyronnet (bib52) 2000; 60 Wang, Proud (bib56) 2002; 91 Waalkes, Udenfriend (bib43) 1957; 50 Shi, Zeng, Ricome, Hannon, Grant, Gerrard (bib89) 2007; 292 Gonçalves, Silveira, Lira, Graça, Paula-Gomes, Zanon (bib70) 2012; 302 Navegantes, Resano, Migliorini, Kettelhut (bib40) 1999; 277 Pankiv, Clausen, Lamark, Brech, Bruun, Outzen (bib49) 2007; 282 Przygodda, Lautherbach, Buzelle, Goncalves, Assis, Paula-Gomes (bib65) 2020; 128 Fernandez-Marcos, Auwerx (bib33) 2011; 93 Chan, Head (bib42) 2010; 5 Herzig, Long, Jhala, Hedrick, Quinn, Bauer (bib75) 2001; 413 Zhao, Brault, Schild, Cao, Sandri, Schiaffino (bib55) 2007; 6 Ryall, Plant, Gregorevic, Sillence, Lynch (bib41) 2004; 555 Lira, Gonçalves, Parreiras-E-Silva, Zanon, Kettelhut, Navegantes (bib18) 2011; 44 Lira, Graca, Goncalves, Zanon, Baviera, Strindberg (bib72) 2007; 27 Bale, Hoshijima, Gu, Dalton, Anderson, Lee (bib11) 2004; 101 Keiper, Stope, Szatkowski, Böhm, Tysack, Vom Dorp (bib83) 2004; 279 Lovenberg, Liaw, Grigoriadist, Clevenger, Chalmerst, Souzat (bib4) 1995; 92 Chanalaris, Lawrence, Stephanou, Knight, Hsu, Hsueh (bib91) 2003; 35 Gonçalves, Silveira, Manfredi, Graça, Armani, Bertaggia (bib19) 2019; 10 Wiley, Davenport (bib12) 2004; 143 Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen (bib20) 1996; 15 Kishimoto (10.1016/j.molmet.2022.101492_bib3) 1995; 92 Vaughan (10.1016/j.molmet.2022.101492_bib46) 2013; 154 Zhang (10.1016/j.molmet.2022.101492_bib63) 2011; 6 Wu (10.1016/j.molmet.2022.101492_bib48) 2005; 25 Costelli (10.1016/j.molmet.2022.101492_bib71) 1995; 95 Mei (10.1016/j.molmet.2022.101492_bib81) 2002; 277 LeRoith (10.1016/j.molmet.2022.101492_bib22) 1995; 16 Yang (10.1016/j.molmet.2022.101492_bib27) 2008; 10 Ueyama (10.1016/j.molmet.2022.101492_bib87) 2000; 32 Inoki (10.1016/j.molmet.2022.101492_bib25) 2003; 115 Zhao (10.1016/j.molmet.2022.101492_bib55) 2007; 6 Singh (10.1016/j.molmet.2022.101492_bib34) 2015; 290 Chen (10.1016/j.molmet.2022.101492_bib6) 2004; 145 Wang (10.1016/j.molmet.2022.101492_bib56) 2002; 91 Reyes (10.1016/j.molmet.2022.101492_bib1) 2001; 98 Roy (10.1016/j.molmet.2022.101492_bib28) 2010; 5 Navegantes (10.1016/j.molmet.2022.101492_bib68) 2000; 279 Bueno (10.1016/j.molmet.2022.101492_bib86) 2000; 19 Geng (10.1016/j.molmet.2022.101492_bib53) 2008; 9 Gonçalves (10.1016/j.molmet.2022.101492_bib19) 2019; 10 Milan (10.1016/j.molmet.2022.101492_bib32) 2015; 6 Sandri (10.1016/j.molmet.2022.101492_bib76) 2006; 103 Gao (10.1016/j.molmet.2022.101492_bib39) 2015; 398 Butler (10.1016/j.molmet.2022.101492_bib21) 1998; 121 Fernandez-Marcos (10.1016/j.molmet.2022.101492_bib33) 2011; 93 Chan (10.1016/j.molmet.2022.101492_bib42) 2010; 5 Baviera (10.1016/j.molmet.2022.101492_bib66) 2010; 315 Perrin (10.1016/j.molmet.2022.101492_bib5) 1999; 885 Kelleher (10.1016/j.molmet.2022.101492_bib57) 2004; 116 Mammucari (10.1016/j.molmet.2022.101492_bib29) 2007; 6 Navegantes (10.1016/j.molmet.2022.101492_bib67) 2001; 281 Kuperman (10.1016/j.molmet.2022.101492_bib17) 2011; 25 Borg (10.1016/j.molmet.2022.101492_bib79) 2019; 68 Chanalaris (10.1016/j.molmet.2022.101492_bib91) 2003; 35 Hsu (10.1016/j.molmet.2022.101492_bib2) 2001; 7 Chen (10.1016/j.molmet.2022.101492_bib13) 2006; 103 Wiley (10.1016/j.molmet.2022.101492_bib12) 2004; 143 Hinkle (10.1016/j.molmet.2022.101492_bib59) 2004; 25 Liu (10.1016/j.molmet.2022.101492_bib64) 2016; 126 Borg (10.1016/j.molmet.2022.101492_bib16) 2021; 12 Baviera (10.1016/j.molmet.2022.101492_bib73) 2007; 292 Jesinkey (10.1016/j.molmet.2022.101492_bib62) 2014; 351 Dimmeler (10.1016/j.molmet.2022.101492_bib47) 1999; 399 Murgia (10.1016/j.molmet.2022.101492_bib37) 2000; 2 Gonçalves (10.1016/j.molmet.2022.101492_bib70) 2012; 302 Lovenberg (10.1016/j.molmet.2022.101492_bib4) 1995; 92 Hinkle (10.1016/j.molmet.2022.101492_bib15) 2003; 285 Lira (10.1016/j.molmet.2022.101492_bib18) 2011; 44 Brar (10.1016/j.molmet.2022.101492_bib93) 2004; 145 Myers (10.1016/j.molmet.2022.101492_bib23) 1994; 269 Navegantes (10.1016/j.molmet.2022.101492_bib40) 1999; 277 Handschin (10.1016/j.molmet.2022.101492_bib74) 2003; 100 Bonaldo (10.1016/j.molmet.2022.101492_bib31) 2013; 6 Hall (10.1016/j.molmet.2022.101492_bib61) 2007; 36 Ju (10.1016/j.molmet.2022.101492_bib45) 2010; 6 Lira (10.1016/j.molmet.2022.101492_bib72) 2007; 27 de Rooij (10.1016/j.molmet.2022.101492_bib50) 1998; 396 Zoncu (10.1016/j.molmet.2022.101492_bib51) 2011; 12 Yang (10.1016/j.molmet.2022.101492_bib36) 2018; 50 Alessi (10.1016/j.molmet.2022.101492_bib20) 1996; 15 Bale (10.1016/j.molmet.2022.101492_bib11) 2004; 101 Sandri (10.1016/j.molmet.2022.101492_bib30) 2004; 117 Bjørkøy (10.1016/j.molmet.2022.101492_bib54) 2005; 171 Wang (10.1016/j.molmet.2022.101492_bib38) 2013; 16 Reutenauer-patte (10.1016/j.molmet.2022.101492_bib60) 2012; 180 Herzig (10.1016/j.molmet.2022.101492_bib75) 2001; 413 Neufeld-Cohen (10.1016/j.molmet.2022.101492_bib10) 2010; 107 Pyronnet (10.1016/j.molmet.2022.101492_bib52) 2000; 60 Yokoyama (10.1016/j.molmet.2022.101492_bib85) 2007; 177 Pankiv (10.1016/j.molmet.2022.101492_bib49) 2007; 282 Geng (10.1016/j.molmet.2022.101492_bib77) 2011; 178 Silveira (10.1016/j.molmet.2022.101492_bib78) 2020; 34 Ryall (10.1016/j.molmet.2022.101492_bib69) 2006; 147 Przygodda (10.1016/j.molmet.2022.101492_bib65) 2020; 128 Roux (10.1016/j.molmet.2022.101492_bib92) 2004; 101 Shi (10.1016/j.molmet.2022.101492_bib89) 2007; 292 Bale (10.1016/j.molmet.2022.101492_bib8) 2000; 24 Lin (10.1016/j.molmet.2022.101492_bib58) 2002; 418 Chao (10.1016/j.molmet.2022.101492_bib80) 2015; 29 Bodine (10.1016/j.molmet.2022.101492_bib24) 2001; 3 Miyazaki (10.1016/j.molmet.2022.101492_bib26) 2017; 7 Hinkle (10.1016/j.molmet.2022.101492_bib90) 2007; 5 Hinkle (10.1016/j.molmet.2022.101492_bib14) 2003; 144 Handschin (10.1016/j.molmet.2022.101492_bib35) 2007; 21 Ryall (10.1016/j.molmet.2022.101492_bib41) 2004; 555 Chen (10.1016/j.molmet.2022.101492_bib9) 2003; 17 Keiper (10.1016/j.molmet.2022.101492_bib83) 2004; 279 Brennesvik (10.1016/j.molmet.2022.101492_bib82) 2005; 17 Coste (10.1016/j.molmet.2022.101492_bib7) 2000; 24 Shi (10.1016/j.molmet.2022.101492_bib88) 2009; 296 Goodman (10.1016/j.molmet.2022.101492_bib44) 2011; 25 Waalkes (10.1016/j.molmet.2022.101492_bib43) 1957; 50 Jones (10.1016/j.molmet.2022.101492_bib84) 2001; 186 |
References_xml | – volume: 5 year: 2010 ident: bib28 article-title: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer publication-title: Journal of Molecular Signaling contributor: fullname: Shankar – volume: 277 start-page: 11497 year: 2002 end-page: 11504 ident: bib81 article-title: Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation publication-title: Journal of Biological Chemistry contributor: fullname: Cheng – volume: 5 year: 2010 ident: bib42 article-title: Age- and gender-related changes in contractile properties of non-atrophied EDL muscle publication-title: PLoS One contributor: fullname: Head – volume: 351 start-page: 663 year: 2014 end-page: 673 ident: bib62 article-title: Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Schnellmann – volume: 25 start-page: 539 year: 2004 end-page: 547 ident: bib59 article-title: Corticotropin releasing factor 2 receptor agonists reduce the denervation-induced loss of rat skeletal muscle mass and force and increase non-atrophying skeletal muscle mass and force publication-title: Journal of Muscle Research & Cell Motility contributor: fullname: Isfort – volume: 7 start-page: 605 year: 2001 end-page: 611 ident: bib2 article-title: Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor publication-title: Nature Medicine contributor: fullname: Hsueh – volume: 315 start-page: 104 year: 2010 end-page: 112 ident: bib66 article-title: Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle publication-title: Molecular and Cellular Endocrinology contributor: fullname: Kettelhut – volume: 413 start-page: 179 year: 2001 end-page: 183 ident: bib75 article-title: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 publication-title: Nature contributor: fullname: Bauer – volume: 6 year: 2015 ident: bib32 article-title: Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy publication-title: Nature Communications contributor: fullname: Frasson – volume: 12 start-page: 21 year: 2011 end-page: 35 ident: bib51 article-title: mTOR: from growth signal integration to cancer, diabetes and ageing publication-title: Nature Reviews Molecular Cell Biology contributor: fullname: Sabatini – volume: 115 start-page: 577 year: 2003 end-page: 590 ident: bib25 article-title: TSC2 mediates cellular energy response to control cell growth and survival publication-title: Cell contributor: fullname: Arbor – volume: 101 start-page: 3697 year: 2004 end-page: 3702 ident: bib11 article-title: The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Lee – volume: 92 start-page: 1108 year: 1995 end-page: 1112 ident: bib3 article-title: A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Rosenfeldt – volume: 285 start-page: E889 year: 2003 end-page: E898 ident: bib15 article-title: Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions publication-title: American Journal of Physiology. Endocrinology and Metabolism contributor: fullname: Bauer – volume: 19 start-page: 6341 year: 2000 end-page: 6350 ident: bib86 article-title: The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice publication-title: The EMBO Journal contributor: fullname: Klevitsky – volume: 121 start-page: 19 year: 1998 end-page: 26 ident: bib21 article-title: Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology publication-title: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology contributor: fullname: LeRoith – volume: 107 start-page: 19020 year: 2010 end-page: 19025 ident: bib10 article-title: A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Lowry – volume: 50 start-page: 1574 year: 2018 end-page: 1584 ident: bib36 article-title: Interaction of CREB and PGC-1α induces fibronectin type III domain-containing protein 5 expression in C2C12 myotubes publication-title: Cellular Physiology and Biochemistry contributor: fullname: Chan – volume: 277 start-page: E883 year: 1999 end-page: E889 ident: bib40 article-title: Effect of guanethidine-induced adrenergic blockade on the different proteolytic systems in rat skeletal muscle publication-title: American Journal of Physiology contributor: fullname: Kettelhut – volume: 180 start-page: 749 year: 2012 end-page: 762 ident: bib60 article-title: Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and epac-dependent pathways publication-title: AJPA contributor: fullname: Dorchies – volume: 60 start-page: 1237 year: 2000 end-page: 1243 ident: bib52 article-title: Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1 publication-title: Biochemical Pharmacology contributor: fullname: Pyronnet – volume: 116 start-page: 467 year: 2004 end-page: 479 ident: bib57 article-title: Translational control by MAPK signaling in long-term synaptic plasticity and memory publication-title: Cell contributor: fullname: Tonegawa – volume: 100 start-page: 7111 year: 2003 end-page: 7116 ident: bib74 article-title: An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Spiegelman – volume: 95 start-page: 2367 year: 1995 end-page: 2372 ident: bib71 article-title: Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway publication-title: Journal of Clinical Investigation contributor: fullname: Agell – volume: 117 start-page: 399 year: 2004 end-page: 412 ident: bib30 article-title: Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy publication-title: Cell contributor: fullname: Picard – volume: 27 start-page: 687 year: 2007 end-page: 694 ident: bib72 article-title: Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats publication-title: Shock contributor: fullname: Strindberg – volume: 396 start-page: 474 year: 1998 end-page: 477 ident: bib50 article-title: Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP publication-title: Nature contributor: fullname: Wittinghofer – volume: 93 year: 2011 ident: bib33 article-title: Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis publication-title: American Journal of Clinical Nutrition contributor: fullname: Auwerx – volume: 12 start-page: 1232 year: 2021 end-page: 1248 ident: bib16 article-title: Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance publication-title: J Cachexia Sarcopenia Muscle contributor: fullname: Lanner – volume: 10 start-page: 455 year: 2019 end-page: 475 ident: bib19 article-title: Insulin/IGF1 signalling mediates the effects of β2 -adrenergic agonist on muscle proteostasis and growth publication-title: J Cachexia Sarcopenia Muscle contributor: fullname: Bertaggia – volume: 101 start-page: 13489 year: 2004 end-page: 13494 ident: bib92 article-title: Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Blenis – volume: 2 start-page: 142 year: 2000 end-page: 147 ident: bib37 article-title: Ras is involved in nerve-activity-dependent regulation of muscle genes publication-title: Nature Cell Biology contributor: fullname: Schiaffino – volume: 25 start-page: 1028 year: 2011 end-page: 1039 ident: bib44 article-title: Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique publication-title: Federation of American Societies for Experimental Biology Journal contributor: fullname: Pierre – volume: 171 start-page: 603 year: 2005 end-page: 614 ident: bib54 article-title: p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death publication-title: The Journal of Cell Biology contributor: fullname: Overvatn – volume: 6 start-page: 929 year: 2010 end-page: 935 ident: bib45 article-title: Quantitation of “autophagic flux” in mature skeletal muscle publication-title: Autophagy contributor: fullname: Weihl – volume: 103 start-page: 16580 year: 2006 end-page: 16585 ident: bib13 article-title: Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Kuperman – volume: 128 start-page: 855 year: 2020 end-page: 871 ident: bib65 article-title: Sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions publication-title: Journal of Applied Physiology contributor: fullname: Paula-Gomes – volume: 35 start-page: 1295 year: 2003 end-page: 1305 ident: bib91 article-title: Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes publication-title: Journal of Molecular and Cellular Cardiology contributor: fullname: Hsueh – volume: 6 year: 2011 ident: bib63 article-title: β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades publication-title: PLoS One contributor: fullname: Tseng – volume: 144 start-page: 4939 year: 2003 end-page: 4946 ident: bib14 article-title: Urocortin II treatment reduces skeletal muscle mass and function loss during atrophy and increases nonatrophying skeletal muscle mass and function publication-title: Endocrinology contributor: fullname: Isfort – volume: 17 start-page: 1551 year: 2005 end-page: 1559 ident: bib82 article-title: Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline publication-title: Cellular Signalling contributor: fullname: Jensen – volume: 50 start-page: 733 year: 1957 end-page: 736 ident: bib43 article-title: A fluorometric method for the estimation of tyrosine in plasma and tissues publication-title: The Journal of Laboratory and Clinical Medicine contributor: fullname: Udenfriend – volume: 154 start-page: 1553 year: 2013 end-page: 1564 ident: bib46 article-title: Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products publication-title: Endocrinology contributor: fullname: Sawchenko – volume: 36 start-page: 336 year: 2007 end-page: 341 ident: bib61 article-title: Effects of a CRF2R agonist and exercise on mdx and wildtype skeletal muscle publication-title: Muscle & Nerve contributor: fullname: Hettinga – volume: 418 start-page: 797 year: 2002 end-page: 801 ident: bib58 article-title: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres publication-title: Nature contributor: fullname: Boss – volume: 398 start-page: 135 year: 2015 end-page: 146 ident: bib39 article-title: Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection publication-title: Molecular and Cellular Biochemistry contributor: fullname: Wang – volume: 885 start-page: 312 year: 1999 end-page: 328 ident: bib5 article-title: Corticotropin releasing factor receptors and their ligand family publication-title: Annals of the New York Academy of Sciences contributor: fullname: Vale – volume: 10 start-page: 138 year: 2008 end-page: 148 ident: bib27 article-title: ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation publication-title: Nature Cell Biology contributor: fullname: Xie – volume: 6 start-page: 472 year: 2007 end-page: 483 ident: bib55 article-title: FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells publication-title: Cell Metabolism contributor: fullname: Schiaffino – volume: 15 start-page: 6541 year: 1996 end-page: 6551 ident: bib20 article-title: Mechanism of activation of protein kinase B by insulin and IGF-1 publication-title: The EMBO Journal contributor: fullname: Cohen – volume: 279 start-page: 46497 year: 2004 end-page: 46508 ident: bib83 article-title: Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors publication-title: Journal of Biological Chemistry contributor: fullname: Vom Dorp – volume: 16 start-page: 143 year: 1995 end-page: 163 ident: bib22 article-title: Molecular and cellular aspects of the insulin-like growth factor I receptor publication-title: Endocrine Reviews contributor: fullname: Roberts – volume: 292 start-page: E702 year: 2007 end-page: E708 ident: bib73 article-title: Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats publication-title: American Journal of Physiology. Endocrinology and Metabolism contributor: fullname: do Carmo Kettelhut – volume: 29 start-page: 831 year: 2015 end-page: 841 ident: bib80 article-title: Involvement of mTOR in type 2 CRF receptor inhibition of insulin signaling in muscle cells publication-title: Molecular Endocrinology contributor: fullname: Harris – volume: 6 start-page: 25 year: 2013 end-page: 39 ident: bib31 article-title: Cellular and molecular mechanisms of muscle atrophy publication-title: Disease Models & Mechanisms contributor: fullname: Sandri – volume: 92 start-page: 836 year: 1995 end-page: 840 ident: bib4 article-title: Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Souzat – volume: 145 start-page: 24 year: 2004 end-page: 35 ident: bib93 article-title: Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart publication-title: Endocrinology contributor: fullname: Perrin – volume: 98 start-page: 2 year: 2001 end-page: 7 ident: bib1 article-title: Urocortin II : a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Arias – volume: 25 start-page: 157 year: 2011 end-page: 169 ident: bib17 article-title: Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle publication-title: Molecular Endocrinology contributor: fullname: Chen – volume: 399 start-page: 601 year: 1999 end-page: 605 ident: bib47 article-title: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation publication-title: Nature contributor: fullname: Zeiher – volume: 126 start-page: 1704 year: 2016 end-page: 1716 ident: bib64 article-title: Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning publication-title: Journal of Clinical Investigation contributor: fullname: Li – volume: 17 start-page: 1622 year: 2003 end-page: 1639 ident: bib9 article-title: Glucocorticoids regulate the expression of the mouse urocortin II gene : a putative connection between the corticotropin-releasing factor receptor pathways publication-title: Molecular Endocrinology contributor: fullname: Vale – volume: 281 start-page: E449 year: 2001 end-page: E454 ident: bib67 article-title: Catecholamines inhibit Ca(2+)-dependent proteolysis in rat skeletal muscle through beta(2)-adrenoceptors and cAMP publication-title: American Journal of Physiology. Endocrinology and Metabolism contributor: fullname: Kettelhut – volume: 147 start-page: 587 year: 2006 end-page: 595 ident: bib69 article-title: Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses publication-title: British Journal of Pharmacology contributor: fullname: Lynch – volume: 5 year: 2007 ident: bib90 article-title: Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice publication-title: BMC Medicine contributor: fullname: Gropp – volume: 178 start-page: 1738 year: 2011 end-page: 1748 ident: bib77 article-title: PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice publication-title: American Journal Of Pathology contributor: fullname: Yan – volume: 25 start-page: 4792 year: 2005 end-page: 4803 ident: bib48 article-title: The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation publication-title: Molecular and Cellular Biology contributor: fullname: Bennett – volume: 279 start-page: E663 year: 2000 end-page: E668 ident: bib68 article-title: Role of adrenoceptors and cAMP on the catecholamine- induced inhibition of proteolysis in rat skeletal muscle publication-title: American Journal of Physiology. Endocrinology and Metabolism contributor: fullname: Migliorini – volume: 3 start-page: 1014 year: 2001 end-page: 1019 ident: bib24 article-title: Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo publication-title: Nature Cell Biology contributor: fullname: Bauerlein – volume: 290 start-page: 950 year: 2015 end-page: 959 ident: bib34 article-title: Relaxin activates peroxisome proliferator-activated receptor γ (PPARγ) through a pathway involving PPARγ coactivator 1α (PGC1α) publication-title: Journal of Biological Chemistry contributor: fullname: Bennett – volume: 16 start-page: 243 year: 2013 end-page: 250 ident: bib38 article-title: Mechanisms for fiber-type specificity of skeletal muscle atrophy publication-title: Current Opinion in Clinical Nutrition and Metabolic Care contributor: fullname: Pessin – volume: 292 start-page: C1681 year: 2007 end-page: C1689 ident: bib89 article-title: Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles publication-title: American Journal of Physiology - Cell Physiology contributor: fullname: Gerrard – volume: 24 start-page: 410 year: 2000 end-page: 414 ident: bib8 article-title: Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress publication-title: Nature Genetics contributor: fullname: Sawchenko – volume: 177 start-page: 781 year: 2007 end-page: 793 ident: bib85 article-title: DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation publication-title: The Journal of Cell Biology contributor: fullname: Takenawa – volume: 21 start-page: 770 year: 2007 end-page: 783 ident: bib35 article-title: PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy publication-title: Genes & Development contributor: fullname: Spiegelman – volume: 186 start-page: 104 year: 2001 end-page: 115 ident: bib84 article-title: ERK1/2 is required for myoblast proliferation but is dispensable for muscle gene expression and cell fusion publication-title: Journal of Cellular Physiology contributor: fullname: Rosenthal – volume: 296 start-page: C1040 year: 2009 end-page: C1048 ident: bib88 article-title: Mitogen-activated protein kinase signaling is necessary for the maintenance of skeletal muscle mass publication-title: American Journal of Physiology - Cell Physiology contributor: fullname: Grant – volume: 302 start-page: E123 year: 2012 end-page: E133 ident: bib70 article-title: Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt publication-title: American Journal of Physiology. Endocrinology and Metabolism contributor: fullname: Zanon – volume: 68 start-page: 1403 year: 2019 end-page: 1414 ident: bib79 article-title: Modified UCN2 peptide acts as an insulin sensitizer in skeletal muscle of obese mice publication-title: Diabetes contributor: fullname: Wade – volume: 44 start-page: 371 year: 2011 end-page: 381 ident: bib18 article-title: Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles publication-title: Muscle & Nerve contributor: fullname: Navegantes – volume: 145 start-page: 2445 year: 2004 end-page: 2457 ident: bib6 article-title: Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids publication-title: Endocrinology contributor: fullname: Biology – volume: 24 start-page: 403 year: 2000 end-page: 409 ident: bib7 article-title: Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 publication-title: Nature Genetics contributor: fullname: Hollis – volume: 7 start-page: 424 year: 2017 end-page: 433 ident: bib26 article-title: TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts publication-title: FEBS Open Bio contributor: fullname: Takemasa – volume: 6 start-page: 458 year: 2007 end-page: 471 ident: bib29 article-title: FoxO3 controls autophagy in skeletal muscle in vivo publication-title: Cell Metabolism contributor: fullname: Del Piccolo – volume: 9 start-page: 859 year: 2008 end-page: 864 ident: bib53 article-title: The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. “Protein modifications: beyond the usual suspects” review series publication-title: EMBO Reports contributor: fullname: Klionsky – volume: 91 start-page: 821 year: 2002 end-page: 829 ident: bib56 article-title: Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes publication-title: Circulation Research contributor: fullname: Proud – volume: 282 start-page: 24131 year: 2007 end-page: 24145 ident: bib49 article-title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy publication-title: Journal of Biological Chemistry contributor: fullname: Outzen – volume: 269 start-page: 28783 year: 1994 end-page: 28789 ident: bib23 article-title: Insulin receptor substrate-1 mediates phosphatidylinositol 3’-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation publication-title: Journal of Biological Chemistry contributor: fullname: Blenis – volume: 34 start-page: 12946 year: 2020 end-page: 12962 ident: bib78 article-title: cAMP-dependent protein kinase inhibits FoxO activity and regulates skeletal muscle plasticity in mice publication-title: The FASEB Journal contributor: fullname: Marcelo – volume: 32 start-page: 947 year: 2000 end-page: 960 ident: bib87 article-title: Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy publication-title: Journal of Molecular and Cellular Cardiology contributor: fullname: Kawai – volume: 103 start-page: 16260 year: 2006 end-page: 16265 ident: bib76 article-title: PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Lecker – volume: 143 start-page: 508 year: 2004 end-page: 514 ident: bib12 article-title: CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators publication-title: British Journal of Pharmacology contributor: fullname: Davenport – volume: 555 start-page: 175 year: 2004 end-page: 188 ident: bib41 article-title: Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats publication-title: The Journal of Physiology contributor: fullname: Lynch – volume: 60 start-page: 1237 issue: 8 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib52 article-title: Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1 publication-title: Biochemical Pharmacology doi: 10.1016/S0006-2952(00)00429-9 contributor: fullname: Pyronnet – volume: 17 start-page: 1551 issue: 12 year: 2005 ident: 10.1016/j.molmet.2022.101492_bib82 article-title: Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline publication-title: Cellular Signalling doi: 10.1016/j.cellsig.2005.03.011 contributor: fullname: Brennesvik – volume: 92 start-page: 836 year: 1995 ident: 10.1016/j.molmet.2022.101492_bib4 article-title: Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.92.3.836 contributor: fullname: Lovenberg – volume: 6 issue: 6670 year: 2015 ident: 10.1016/j.molmet.2022.101492_bib32 article-title: Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy publication-title: Nature Communications contributor: fullname: Milan – volume: 555 start-page: 175 issue: Pt 1 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib41 article-title: Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats publication-title: The Journal of Physiology doi: 10.1113/jphysiol.2003.056770 contributor: fullname: Ryall – volume: 101 start-page: 13489 issue: 37 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib92 article-title: Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0405659101 contributor: fullname: Roux – volume: 24 start-page: 403 issue: 4 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib7 article-title: Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 publication-title: Nature Genetics doi: 10.1038/74255 contributor: fullname: Coste – volume: 7 start-page: 605 issue: 5 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib2 article-title: Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor publication-title: Nature Medicine doi: 10.1038/87936 contributor: fullname: Hsu – volume: 98 start-page: 2 issue: 5 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib1 article-title: Urocortin II : a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors publication-title: Proceedings of the National Academy of Sciences of the United States of America contributor: fullname: Reyes – volume: 12 start-page: 1232 issue: 5 year: 2021 ident: 10.1016/j.molmet.2022.101492_bib16 article-title: Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance publication-title: J Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12746 contributor: fullname: Borg – volume: 101 start-page: 3697 issue: 10 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib11 article-title: The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0307324101 contributor: fullname: Bale – volume: 25 start-page: 157 issue: 1 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib17 article-title: Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle publication-title: Molecular Endocrinology doi: 10.1210/me.2010-0308 contributor: fullname: Kuperman – volume: 269 start-page: 28783 issue: 46 year: 1994 ident: 10.1016/j.molmet.2022.101492_bib23 article-title: Insulin receptor substrate-1 mediates phosphatidylinositol 3’-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(19)61974-5 contributor: fullname: Myers – volume: 147 start-page: 587 issue: 6 year: 2006 ident: 10.1016/j.molmet.2022.101492_bib69 article-title: Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses publication-title: British Journal of Pharmacology doi: 10.1038/sj.bjp.0706669 contributor: fullname: Ryall – volume: 398 start-page: 135 issue: 1–2 year: 2015 ident: 10.1016/j.molmet.2022.101492_bib39 article-title: Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection publication-title: Molecular and Cellular Biochemistry doi: 10.1007/s11010-014-2213-1 contributor: fullname: Gao – volume: 15 start-page: 6541 issue: 23 year: 1996 ident: 10.1016/j.molmet.2022.101492_bib20 article-title: Mechanism of activation of protein kinase B by insulin and IGF-1 publication-title: The EMBO Journal doi: 10.1002/j.1460-2075.1996.tb01045.x contributor: fullname: Alessi – volume: 116 start-page: 467 issue: 3 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib57 article-title: Translational control by MAPK signaling in long-term synaptic plasticity and memory publication-title: Cell doi: 10.1016/S0092-8674(04)00115-1 contributor: fullname: Kelleher – volume: 413 start-page: 179 issue: 6852 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib75 article-title: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 publication-title: Nature doi: 10.1038/35093131 contributor: fullname: Herzig – volume: 9 start-page: 859 issue: 9 year: 2008 ident: 10.1016/j.molmet.2022.101492_bib53 article-title: The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. “Protein modifications: beyond the usual suspects” review series publication-title: EMBO Reports doi: 10.1038/embor.2008.163 contributor: fullname: Geng – volume: 171 start-page: 603 issue: 4 year: 2005 ident: 10.1016/j.molmet.2022.101492_bib54 article-title: p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death publication-title: The Journal of Cell Biology doi: 10.1083/jcb.200507002 contributor: fullname: Bjørkøy – volume: 27 start-page: 687 issue: 6 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib72 article-title: Cyclic adenosine monophosphate-phosphodiesterase inhibitors reduce skeletal muscle protein catabolism in septic rats publication-title: Shock doi: 10.1097/SHK.0b013e31802e43a6 contributor: fullname: Lira – volume: 68 start-page: 1403 issue: 7 year: 2019 ident: 10.1016/j.molmet.2022.101492_bib79 article-title: Modified UCN2 peptide acts as an insulin sensitizer in skeletal muscle of obese mice publication-title: Diabetes doi: 10.2337/db18-1237 contributor: fullname: Borg – volume: 178 start-page: 1738 issue: 4 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib77 article-title: PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice publication-title: American Journal Of Pathology doi: 10.1016/j.ajpath.2011.01.005 contributor: fullname: Geng – volume: 144 start-page: 4939 issue: 11 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib14 article-title: Urocortin II treatment reduces skeletal muscle mass and function loss during atrophy and increases nonatrophying skeletal muscle mass and function publication-title: Endocrinology doi: 10.1210/en.2003-0271 contributor: fullname: Hinkle – volume: 121 start-page: 19 issue: 1 year: 1998 ident: 10.1016/j.molmet.2022.101492_bib21 article-title: Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology publication-title: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology doi: 10.1016/S0305-0491(98)10106-2 contributor: fullname: Butler – volume: 302 start-page: E123 issue: 1 year: 2012 ident: 10.1016/j.molmet.2022.101492_bib70 article-title: Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.00188.2011 contributor: fullname: Gonçalves – volume: 117 start-page: 399 issue: 3 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib30 article-title: Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy publication-title: Cell doi: 10.1016/S0092-8674(04)00400-3 contributor: fullname: Sandri – volume: 93 issue: 4 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib33 article-title: Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis publication-title: American Journal of Clinical Nutrition doi: 10.3945/ajcn.110.001917 contributor: fullname: Fernandez-Marcos – volume: 396 start-page: 474 issue: 6710 year: 1998 ident: 10.1016/j.molmet.2022.101492_bib50 article-title: Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP publication-title: Nature doi: 10.1038/24884 contributor: fullname: de Rooij – volume: 12 start-page: 21 issue: 1 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib51 article-title: mTOR: from growth signal integration to cancer, diabetes and ageing publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm3025 contributor: fullname: Zoncu – volume: 281 start-page: E449 issue: 3 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib67 article-title: Catecholamines inhibit Ca(2+)-dependent proteolysis in rat skeletal muscle through beta(2)-adrenoceptors and cAMP publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.2001.281.3.E449 contributor: fullname: Navegantes – volume: 6 start-page: 25 issue: 1 year: 2013 ident: 10.1016/j.molmet.2022.101492_bib31 article-title: Cellular and molecular mechanisms of muscle atrophy publication-title: Disease Models & Mechanisms doi: 10.1242/dmm.010389 contributor: fullname: Bonaldo – volume: 279 start-page: 46497 issue: 45 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib83 article-title: Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M403604200 contributor: fullname: Keiper – volume: 25 start-page: 1028 issue: 3 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib44 article-title: Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique publication-title: Federation of American Societies for Experimental Biology Journal doi: 10.1096/fj.10-168799 contributor: fullname: Goodman – volume: 50 start-page: 1574 issue: 4 year: 2018 ident: 10.1016/j.molmet.2022.101492_bib36 article-title: Interaction of CREB and PGC-1α induces fibronectin type III domain-containing protein 5 expression in C2C12 myotubes publication-title: Cellular Physiology and Biochemistry doi: 10.1159/000494655 contributor: fullname: Yang – volume: 16 start-page: 143 issue: 2 year: 1995 ident: 10.1016/j.molmet.2022.101492_bib22 article-title: Molecular and cellular aspects of the insulin-like growth factor I receptor publication-title: Endocrine Reviews doi: 10.1210/edrv-16-2-143 contributor: fullname: LeRoith – volume: 6 issue: 10 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib63 article-title: β-Adrenergic receptor-PI3K signaling crosstalk in mouse heart: elucidation of immediate downstream signaling cascades publication-title: PLoS One doi: 10.1371/journal.pone.0026581 contributor: fullname: Zhang – volume: 107 start-page: 19020 issue: 44 year: 2010 ident: 10.1016/j.molmet.2022.101492_bib10 article-title: A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1013761107 contributor: fullname: Neufeld-Cohen – volume: 6 start-page: 929 issue: 7 year: 2010 ident: 10.1016/j.molmet.2022.101492_bib45 article-title: Quantitation of “autophagic flux” in mature skeletal muscle publication-title: Autophagy doi: 10.4161/auto.6.7.12785 contributor: fullname: Ju – volume: 277 start-page: 11497 issue: 13 year: 2002 ident: 10.1016/j.molmet.2022.101492_bib81 article-title: Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M110856200 contributor: fullname: Mei – volume: 100 start-page: 7111 issue: 12 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib74 article-title: An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1232352100 contributor: fullname: Handschin – volume: 10 start-page: 455 issue: 2 year: 2019 ident: 10.1016/j.molmet.2022.101492_bib19 article-title: Insulin/IGF1 signalling mediates the effects of β2 -adrenergic agonist on muscle proteostasis and growth publication-title: J Cachexia Sarcopenia Muscle doi: 10.1002/jcsm.12395 contributor: fullname: Gonçalves – volume: 36 start-page: 336 issue: 3 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib61 article-title: Effects of a CRF2R agonist and exercise on mdx and wildtype skeletal muscle publication-title: Muscle & Nerve doi: 10.1002/mus.20820 contributor: fullname: Hall – volume: 6 start-page: 472 issue: 6 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib55 article-title: FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells publication-title: Cell Metabolism doi: 10.1016/j.cmet.2007.11.004 contributor: fullname: Zhao – volume: 5 issue: 18 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib90 article-title: Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice publication-title: BMC Medicine contributor: fullname: Hinkle – volume: 115 start-page: 577 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib25 article-title: TSC2 mediates cellular energy response to control cell growth and survival publication-title: Cell doi: 10.1016/S0092-8674(03)00929-2 contributor: fullname: Inoki – volume: 10 start-page: 138 issue: 2 year: 2008 ident: 10.1016/j.molmet.2022.101492_bib27 article-title: ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation publication-title: Nature Cell Biology doi: 10.1038/ncb1676 contributor: fullname: Yang – volume: 351 start-page: 663 issue: 3 year: 2014 ident: 10.1016/j.molmet.2022.101492_bib62 article-title: Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice publication-title: Journal of Pharmacology and Experimental Therapeutics doi: 10.1124/jpet.114.217380 contributor: fullname: Jesinkey – volume: 143 start-page: 508 issue: 4 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib12 article-title: CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators publication-title: British Journal of Pharmacology doi: 10.1038/sj.bjp.0705985 contributor: fullname: Wiley – volume: 285 start-page: E889 issue: 4 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib15 article-title: Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.00081.2003 contributor: fullname: Hinkle – volume: 29 start-page: 831 issue: 6 year: 2015 ident: 10.1016/j.molmet.2022.101492_bib80 article-title: Involvement of mTOR in type 2 CRF receptor inhibition of insulin signaling in muscle cells publication-title: Molecular Endocrinology doi: 10.1210/me.2014-1245 contributor: fullname: Chao – volume: 25 start-page: 4792 issue: 11 year: 2005 ident: 10.1016/j.molmet.2022.101492_bib48 article-title: The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.25.11.4792-4803.2005 contributor: fullname: Wu – volume: 180 start-page: 749 issue: 2 year: 2012 ident: 10.1016/j.molmet.2022.101492_bib60 article-title: Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and epac-dependent pathways publication-title: AJPA contributor: fullname: Reutenauer-patte – volume: 34 start-page: 12946 issue: 9 year: 2020 ident: 10.1016/j.molmet.2022.101492_bib78 article-title: cAMP-dependent protein kinase inhibits FoxO activity and regulates skeletal muscle plasticity in mice publication-title: The FASEB Journal doi: 10.1096/fj.201902102RR contributor: fullname: Silveira – volume: 315 start-page: 104 issue: 1–2 year: 2010 ident: 10.1016/j.molmet.2022.101492_bib66 article-title: Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle publication-title: Molecular and Cellular Endocrinology doi: 10.1016/j.mce.2009.09.028 contributor: fullname: Baviera – volume: 154 start-page: 1553 issue: 4 year: 2013 ident: 10.1016/j.molmet.2022.101492_bib46 article-title: Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products publication-title: Endocrinology doi: 10.1210/en.2012-2011 contributor: fullname: Vaughan – volume: 91 start-page: 821 issue: 9 year: 2002 ident: 10.1016/j.molmet.2022.101492_bib56 article-title: Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes publication-title: Circulation Research doi: 10.1161/01.RES.0000041029.97988.E9 contributor: fullname: Wang – volume: 92 start-page: 1108 year: 1995 ident: 10.1016/j.molmet.2022.101492_bib3 article-title: A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.92.4.1108 contributor: fullname: Kishimoto – volume: 32 start-page: 947 issue: 6 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib87 article-title: Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy publication-title: Journal of Molecular and Cellular Cardiology doi: 10.1006/jmcc.2000.1135 contributor: fullname: Ueyama – volume: 44 start-page: 371 issue: 3 year: 2011 ident: 10.1016/j.molmet.2022.101492_bib18 article-title: Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles publication-title: Muscle & Nerve doi: 10.1002/mus.22066 contributor: fullname: Lira – volume: 95 start-page: 2367 issue: 5 year: 1995 ident: 10.1016/j.molmet.2022.101492_bib71 article-title: Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway publication-title: Journal of Clinical Investigation doi: 10.1172/JCI117929 contributor: fullname: Costelli – volume: 885 start-page: 312 year: 1999 ident: 10.1016/j.molmet.2022.101492_bib5 article-title: Corticotropin releasing factor receptors and their ligand family publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.1999.tb08687.x contributor: fullname: Perrin – volume: 2 start-page: 142 issue: 3 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib37 article-title: Ras is involved in nerve-activity-dependent regulation of muscle genes publication-title: Nature Cell Biology doi: 10.1038/35004013 contributor: fullname: Murgia – volume: 17 start-page: 1622 issue: 8 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib9 article-title: Glucocorticoids regulate the expression of the mouse urocortin II gene : a putative connection between the corticotropin-releasing factor receptor pathways publication-title: Molecular Endocrinology doi: 10.1210/me.2003-0054 contributor: fullname: Chen – volume: 3 start-page: 1014 issue: 11 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib24 article-title: Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo publication-title: Nature Cell Biology doi: 10.1038/ncb1101-1014 contributor: fullname: Bodine – volume: 177 start-page: 781 issue: 5 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib85 article-title: DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation publication-title: The Journal of Cell Biology doi: 10.1083/jcb.200703195 contributor: fullname: Yokoyama – volume: 282 start-page: 24131 issue: 33 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib49 article-title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M702824200 contributor: fullname: Pankiv – volume: 6 start-page: 458 issue: 6 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib29 article-title: FoxO3 controls autophagy in skeletal muscle in vivo publication-title: Cell Metabolism doi: 10.1016/j.cmet.2007.11.001 contributor: fullname: Mammucari – volume: 16 start-page: 243 issue: 3 year: 2013 ident: 10.1016/j.molmet.2022.101492_bib38 article-title: Mechanisms for fiber-type specificity of skeletal muscle atrophy publication-title: Current Opinion in Clinical Nutrition and Metabolic Care doi: 10.1097/MCO.0b013e328360272d contributor: fullname: Wang – volume: 290 start-page: 950 issue: 2 year: 2015 ident: 10.1016/j.molmet.2022.101492_bib34 article-title: Relaxin activates peroxisome proliferator-activated receptor γ (PPARγ) through a pathway involving PPARγ coactivator 1α (PGC1α) publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M114.589325 contributor: fullname: Singh – volume: 277 start-page: E883 issue: 5 year: 1999 ident: 10.1016/j.molmet.2022.101492_bib40 article-title: Effect of guanethidine-induced adrenergic blockade on the different proteolytic systems in rat skeletal muscle publication-title: American Journal of Physiology contributor: fullname: Navegantes – volume: 35 start-page: 1295 issue: 10 year: 2003 ident: 10.1016/j.molmet.2022.101492_bib91 article-title: Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes publication-title: Journal of Molecular and Cellular Cardiology doi: 10.1016/S0022-2828(03)00244-X contributor: fullname: Chanalaris – volume: 24 start-page: 410 issue: 4 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib8 article-title: Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress publication-title: Nature Genetics doi: 10.1038/74263 contributor: fullname: Bale – volume: 103 start-page: 16580 issue: 44 year: 2006 ident: 10.1016/j.molmet.2022.101492_bib13 article-title: Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0607337103 contributor: fullname: Chen – volume: 126 start-page: 1704 issue: 5 year: 2016 ident: 10.1016/j.molmet.2022.101492_bib64 article-title: Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning publication-title: Journal of Clinical Investigation doi: 10.1172/JCI83532 contributor: fullname: Liu – volume: 103 start-page: 16260 issue: 44 year: 2006 ident: 10.1016/j.molmet.2022.101492_bib76 article-title: PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0607795103 contributor: fullname: Sandri – volume: 296 start-page: C1040 issue: 5 year: 2009 ident: 10.1016/j.molmet.2022.101492_bib88 article-title: Mitogen-activated protein kinase signaling is necessary for the maintenance of skeletal muscle mass publication-title: American Journal of Physiology - Cell Physiology doi: 10.1152/ajpcell.00475.2008 contributor: fullname: Shi – volume: 21 start-page: 770 issue: 7 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib35 article-title: PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy publication-title: Genes & Development doi: 10.1101/gad.1525107 contributor: fullname: Handschin – volume: 292 start-page: E702 issue: 3 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib73 article-title: Pentoxifylline inhibits Ca2+-dependent and ATP proteasome-dependent proteolysis in skeletal muscle from acutely diabetic rats publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.00147.2006 contributor: fullname: Baviera – volume: 7 start-page: 424 issue: 3 year: 2017 ident: 10.1016/j.molmet.2022.101492_bib26 article-title: TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts publication-title: FEBS Open Bio doi: 10.1002/2211-5463.12195 contributor: fullname: Miyazaki – volume: 19 start-page: 6341 issue: 23 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib86 article-title: The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice publication-title: The EMBO Journal doi: 10.1093/emboj/19.23.6341 contributor: fullname: Bueno – volume: 279 start-page: E663 issue: 3 year: 2000 ident: 10.1016/j.molmet.2022.101492_bib68 article-title: Role of adrenoceptors and cAMP on the catecholamine- induced inhibition of proteolysis in rat skeletal muscle publication-title: American Journal of Physiology. Endocrinology and Metabolism doi: 10.1152/ajpendo.2000.279.3.E663 contributor: fullname: Navegantes – volume: 145 start-page: 2445 issue: 5 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib6 article-title: Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids publication-title: Endocrinology doi: 10.1210/en.2003-1570 contributor: fullname: Chen – volume: 128 start-page: 855 issue: 4 year: 2020 ident: 10.1016/j.molmet.2022.101492_bib65 article-title: Sympathetic innervation suppresses the autophagic-lysosomal system in brown adipose tissue under basal and cold-stimulated conditions publication-title: Journal of Applied Physiology doi: 10.1152/japplphysiol.00065.2019 contributor: fullname: Przygodda – volume: 292 start-page: C1681 issue: 5 year: 2007 ident: 10.1016/j.molmet.2022.101492_bib89 article-title: Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles publication-title: American Journal of Physiology - Cell Physiology doi: 10.1152/ajpcell.00466.2006 contributor: fullname: Shi – volume: 50 start-page: 733 issue: 5 year: 1957 ident: 10.1016/j.molmet.2022.101492_bib43 article-title: A fluorometric method for the estimation of tyrosine in plasma and tissues publication-title: The Journal of Laboratory and Clinical Medicine contributor: fullname: Waalkes – volume: 186 start-page: 104 issue: 1 year: 2001 ident: 10.1016/j.molmet.2022.101492_bib84 article-title: ERK1/2 is required for myoblast proliferation but is dispensable for muscle gene expression and cell fusion publication-title: Journal of Cellular Physiology doi: 10.1002/1097-4652(200101)186:1<104::AID-JCP1015>3.0.CO;2-0 contributor: fullname: Jones – volume: 145 start-page: 24 issue: 1 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib93 article-title: Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart publication-title: Endocrinology doi: 10.1210/en.2003-0689 contributor: fullname: Brar – volume: 5 issue: 10 year: 2010 ident: 10.1016/j.molmet.2022.101492_bib28 article-title: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer publication-title: Journal of Molecular Signaling contributor: fullname: Roy – volume: 25 start-page: 539 issue: 7 year: 2004 ident: 10.1016/j.molmet.2022.101492_bib59 article-title: Corticotropin releasing factor 2 receptor agonists reduce the denervation-induced loss of rat skeletal muscle mass and force and increase non-atrophying skeletal muscle mass and force publication-title: Journal of Muscle Research & Cell Motility doi: 10.1007/s10974-004-4088-3 contributor: fullname: Hinkle – volume: 418 start-page: 797 issue: 6899 year: 2002 ident: 10.1016/j.molmet.2022.101492_bib58 article-title: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres publication-title: Nature doi: 10.1038/nature00904 contributor: fullname: Lin – volume: 399 start-page: 601 issue: 6736 year: 1999 ident: 10.1016/j.molmet.2022.101492_bib47 article-title: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation publication-title: Nature doi: 10.1038/21224 contributor: fullname: Dimmeler – volume: 5 issue: 8 year: 2010 ident: 10.1016/j.molmet.2022.101492_bib42 article-title: Age- and gender-related changes in contractile properties of non-atrophied EDL muscle publication-title: PLoS One doi: 10.1371/journal.pone.0012345 contributor: fullname: Chan |
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Snippet | Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific... OBJECTIVEAlthough it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific... • Ucn2 overexpression promotes muscle growth due to an increase in protein synthesis. • Ucn2 inhibits FoxO activity and autophagic-lysosomal system. •... Objective: Although it is well established that urocortin 2 (Ucn2), a peptide member of the corticotrophin releasing factor (CRF) family, and its specific... |
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SubjectTerms | Adrenocorticotropic Hormone - metabolism Adrenocorticotropic Hormone - pharmacology Animals cAMP Corticotropin-Releasing Hormone - metabolism Fatigue resistance Hypertrophy Hypertrophy - metabolism Insulin - metabolism Insulin-Like Growth Factor I - metabolism Mice Muscle, Skeletal - metabolism Original Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Urocortin 2 Urocortins - metabolism Urocortins - pharmacology |
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Title | Urocortin 2 promotes hypertrophy and enhances skeletal muscle function through cAMP and insulin/IGF-1 signaling pathways |
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