Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

• Published in: American journal of respiratory and critical care medicine Vol. 191; no. 3; pp. 309 - 315
• Main Authors: Wong, Hector R., Cvijanovich, Natalie Z., Anas, Nick, Allen, Geoffrey L., Thomas, Neal J., Bigham, Michael T., Weiss, Scott L., Fitzgerald, Julie, Checchia, Paul A., Meyer, Keith, Shanley, Thomas P., Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J., Nowak, Jeffrey, Shekhar, Raj S., Gertz, Shira, Dawson, Emily, Howard, Kelli, Harmon, Kelli, Beckman, Eileen, Frank, Erin, Lindsell, Christopher J.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.02.2015
• Subjects: Child; Child, Preschool; Feasibility Studies; Female; Gene Expression Regulation; Glucocorticoids - therapeutic use; Humans; Infant; Intensive Care Units, Pediatric; Male; Mathematical Computing; Odds Ratio; Original; Phenotype; Precision Medicine; Prospective Studies; Reproducibility of Results; Severity of Illness Index; Shock, Septic - diagnosis; Shock, Septic - genetics; Shock, Septic - mortality; Shock, Septic - therapy; Signal Transduction - genetics; United States > US; glucocorticoids; subclassification; adaptive immunity; gene expression; sepsis

Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranostic implicati...