Distinct roles for TET family proteins in regulating human erythropoiesis

• Published in: Blood Vol. 129; no. 14; pp. 2002 - 2012
• Main Authors: Yan, Hongxia, Wang, Yaomei, Qu, Xiaoli, Li, Jie, Hale, John, Huang, Yumin, An, Chao, Papoin, Julien, Guo, Xinhua, Chen, Lixiang, Kang, Qiaozhen, Li, Wei, Schulz, Vincent P., Gallagher, Patrick G., Hillyer, Christopher D., Mohandas, Narla, An, Xiuli
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2017; American Society of Hematology
• Subjects: Antigens, CD34 - genetics; Antigens, CD34 - metabolism; Dioxygenases - genetics; Dioxygenases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Erythropoiesis - physiology; Gene Knockdown Techniques; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - metabolism; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Red Cells, Iron, and Erythropoiesis

The ten-eleven translocation (TET) family of proteins plays important roles in a wide range of biological processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine. However, their function in erythropoiesis has remained unclear. We show here that TET2 and TET3 but not TET1 are expres...