Delayed histologic damage and neuron death in the substantia nigra reticulata following transient forebrain ischemia depends on the extent of initial striatal injury

• Published in: Neuroscience letters Vol. 155; no. 1; pp. 47 - 50
• Main Authors: Saji, Makoto, Volpe, Bruce T.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 28.05.1993; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Death; Delayed degeneration; Globus pallidus; Ischemia; Ischemic Attack, Transient - pathology; Male; Medical sciences; Nerve Degeneration; Nervous system involvement in other diseases. Miscellaneous; Neurology; Neurons - pathology; Prosencephalon - blood supply; Rats; Rats, Wistar; Striatum; Substantia Nigra - pathology; Substantia nigra reticulata; Globus pallidus; Striatum; Substantia nigra reticulata; Delayed degeneration; Ischemia; Nervous system diseases; Rat; Rodentia; Central nervous system; Basal ganglion; Corpus striatum; Pathology; Vertebrata; Experimental disease; Mammalia; Locus niger; Cell death; Animal; Degeneration; Cerebrovascular disease; Nigrostriatal pathway; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(93)90670-G

Transient forebrain ischemia in normoglycemic, normotensive rodents reproducibly causes selectively vulnerable neurons in the striatum to degenerate within 24 h. Neurons in the substantia nigra reticulata (SNR) are resistant to this acute process. Histologic evidence demonstrates that the combination of acute ischemic injury to the caudate nucleus and globus pallidus is associated with delayed neuron degeneration in the SNR that matures at 3 weeks after reperfusion. Ischemia, like certain ablative neurotoxin lesions, may provoke degenerative, perhaps transneuronal events that continue to evolve long after the initial insult.