Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production - Gassaway, Brandon M.; Cardone, Rebecca L.; Padyana, Anil K.; Petersen, Max C.; Judd, Evan T.; Hayes, Sebastian; Tong, Shuilong; Barber, Karl W.; Apostolidi, Maria; Abulizi, Abudukadier; Sheetz, Joshua B.; Kshitiz; et al. (Cell reports (Cambridge), 2019)
Keywords: Animals; Cell Line, Tumor; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases - metabolism; cyclin-dependent kinase; Cyclin-Dependent Kinases - metabolism; Diet, High-Fat; enzyme regulation; Gluconeogenesis; Glucose - metabolism; hepatic glucose production; Hepatocytes - metabolism; Insulin Resistance; Male; metabolism; nuclear localization; Phosphorylation; pyruvate kinase; Pyruvate Kinase - chemistry; Pyruvate Kinase - metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction; sub-cellular localization; sub-cellular localization; hepatic glucose production; enzyme regulation; pyruvate kinase; nuclear localization; metabolism; cyclin-dependent kinase; phosphorylation; insulin resistance