Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity

• Published in: Current research in structural biology Vol. 3; pp. 324 - 336
• Main Authors: Argyriou, Aikaterini I., Makrynitsa, Garyfallia I., Dalkas, Georgios, Georgopoulou, Dimitra A., Salagiannis, Konstantinos, Vazoura, Vassiliki, Papapetropoulos, Andreas, Topouzis, Stavros, Spyroulias, Georgios A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021; Elsevier
• Subjects: BAY 58-2667; BAY 60-2770; Cinaciguat; H-NOX; Heme; Soluble guanylate cyclase (sGC); BAY 60-2770; BAY 58-2667; H-NOX; Heme; Soluble guanylate cyclase (sGC); Cinaciguat

The gasotransmitter nitric oxide (NO) is a critical endogenous regulator of homeostasis, in major part via the generation of cGMP (cyclic guanosine monophosphate) from GTP (guanosine triphosphate) by NO's main physiological receptor, the soluble guanylate cyclase (sGC). sGC is a heterodimer, co...