Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer

• Published in: Molecular cancer therapeutics Vol. 14; no. 3; pp. 642 - 648
• Main Authors: Li, Xiaokai, Colvin, Teresa, Rauch, Jennifer N, Acosta-Alvear, Diego, Kampmann, Martin, Dunyak, Bryan, Hann, Byron, Aftab, Blake T, Murnane, Megan, Cho, Min, Walter, Peter, Weissman, Jonathan S, Sherman, Michael Y, Gestwicki, Jason E
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Antineoplastic Agents - pharmacology; Apoptosis Regulatory Proteins - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Forkhead Box Protein M1; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic - drug effects; HeLa Cells; HSP70 Heat-Shock Proteins - metabolism; HT29 Cells; Humans; MCF-7 Cells; Mice; Proliferating Cell Nuclear Antigen - metabolism; Protein Interaction Domains and Motifs - physiology

Hsp70 is a stress-inducible molecular chaperone that is required for cancer development at several steps. Targeting the active site of Hsp70 has proven relatively challenging, driving interest in alternative approaches. Hsp70 collaborates with the Bcl2-associated athanogene 3 (Bag3) to promote cell...