Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease

• Published in: Neuron (Cambridge, Mass.) Vol. 110; no. 18; pp. 2929 - 2948.e8
• Main Authors: Otero-Garcia, Marcos, Mahajani, Sameehan U., Wakhloo, Debia, Tang, Weijing, Xue, Yue-Qiang, Morabito, Samuel, Pan, Jie, Oberhauser, Jane, Madira, Angela E., Shakouri, Tamara, Deng, Yongning, Allison, Thomas, He, Zihuai, Lowry, William E., Kawaguchi, Riki, Swarup, Vivek, Cobos, Inma
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.09.2022
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; amyloid; biomarkers; Biomarkers - metabolism; Brain - metabolism; dementia; Humans; neurodegeneration; Neurofibrillary Tangles - metabolism; neuropathology; selective vulnerability; single-cell RNA-seq; single-nucleus RNA-seq; tau Proteins - genetics; tau Proteins - metabolism; tauopathies; transcriptomics; amyloid; biomarkers; neurodegeneration; transcriptomics; dementia; single-cell RNA-seq; tauopathies; selective vulnerability; single-nucleus RNA-seq; neuropathology

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with neurodegeneration and cognitive decline in Alzheimer’s disease (AD). However, the molecular signatures that distinguish between aggregation-prone and aggregation-resistant cell states are unknown. We developed methods for t...