Radiotherapy delays malignant transformation and prolongs survival in patients with IDH-mutant gliomas

• Published in: Cancer biology & medicine Vol. 19; no. 10; pp. 1477 - 1486
• Main Authors: Liu, Yanwei, Chen, Huiyuan, Li, Guanzhang, Zhang, Jing, Yao, Kun, Wu, Chenxing, Li, Shouwei, Qiu, Xiaoguang
• Format: Journal Article
• Language: English
• Published: China Department of Neuropathology,Beijing Neurosurgical Institute,Capital Medical University,Beijing 100070,China%National Clinical Research Center for Neurological Diseases,Beijing 100070,China 01.11.2022; Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China%Department of Neuropathology%Department of Neurosurgery,Sanbo Brain Hospital,Capital Medical University,Beijing 100093,China; National Clinical Research Center for Neurological Diseases,Beijing 100070,China%National Clinical Research Center for Neurological Diseases,Beijing 100070,China; Department of Radiation Oncology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China; Compuscript; China Anti-Cancer Association
• Subjects: Adult; Astrocytoma - genetics; Astrocytoma - radiotherapy; Astrocytoma - surgery; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Brain Neoplasms - radiotherapy; Cell Transformation, Neoplastic - genetics; Glioblastoma; Glioma - genetics; Glioma - pathology; Glioma - radiotherapy; Humans; idh mutation; Isocitrate Dehydrogenase - genetics; lower-grade gliomas; malignant transformation; Middle Aged; Oligodendroglioma; Original; radiotherapy; survival; Young Adult; radiotherapy; IDH mutation; Lower-grade gliomas; malignant transformation; survival

IDH-mutant lower-grade gliomas (LGGs, grade 2 or 3) eventually transform into secondary grade 4 astrocytomas (sA ). Here, we sought to describe the transformation time, risk factors, and outcomes in malignant transformation of IDH-mutant LGGs. We screened data for 108 patients with sA in the Chinese...