STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production

• Published in: Blood Vol. 130; no. 13; pp. 1565 - 1577
• Main Authors: Clemens, Regina A., Chong, Joshua, Grimes, Derayvia, Hu, Yongmei, Lowell, Clifford A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.09.2017; American Society of Hematology
• Subjects: Animals; Calcium - metabolism; Calcium Channels - metabolism; Cytokines - biosynthesis; Mice; Neutrophil Activation; Oxidation-Reduction; Phagocytes, Granulocytes, and Myelopoiesis; Stromal Interaction Molecule 1 - immunology; Stromal Interaction Molecule 1 - physiology; Stromal Interaction Molecule 2 - immunology; Stromal Interaction Molecule 2 - physiology

Neutrophils are key effector cells of the innate immune system. Calcium-dependent signaling pathways initiated by store-operated calcium entry (SOCE) are known to regulate neutrophil activation; however, the precise mechanism of this process remains unclear. STIM1 and STIM2 are calcium-sensing molec...