Allergen-induced increase of eosinophil cationic protein in nasal lavage fluid: Effect of the glucocorticoid budesonide
It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days after...
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Published in | Journal of allergy and clinical immunology Vol. 85; no. 5; pp. 891 - 895 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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New York, NY
Mosby, Inc
01.05.1990
Elsevier |
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Abstract | It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days after pretreatment for 2 weeks with the glucocorticoid, budesonide as a nasal spray (400 μg/day) and with placebo with a double-blind, crossover design. Nasal lavage fluid was repeatedly collected during a 10-hour period to study both early and late-phase responses.
99mTechnetium-albumin was added to the lavage fluid, making it possible to calculate the amount of secretion and the degree of dilution. The results were as follows: (1) There was no correlation between ECP concentration and dilution factor in the individual samples. (2) The mean concentration of ECP in lavage fluid from untreated, prechallenge noses was 400 μg/L. (3) The ECP level did not increase during the early phase response. (4) There was a late occurring increase in the ECP concentration (6 to 24 hours). (5) This increase was completely inhibited by budesonide pretreatment. (6) The glucocorticoid therapy also reduced the prechallenge ECP concentration. In conclusion, allergen provocation in the nose results in a late occurring increase of ECP in nasal lavage fluid, and one of the therapeutic effects of topical glucocorticoid therapy may be an inhibition of the allergen-induced increase of this cytotoxic molecule. |
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AbstractList | It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days after pretreatment for 2 weeks with the glucocorticoid, budesonide, as a nasal spray (400 micrograms/day) and with placebo with a double-blind, crossover design. Nasal lavage fluid was repeatedly collected during a 10-hour period to study both early and late-phase responses. 99mTechnetium-albumin was added to the lavage fluid, making it possible to calculate the amount of secretion and the degree of dilution. The results were as follows: (1) There was no correlation between ECP concentration and dilution factor in the individual samples. (2) The mean concentration of ECP in lavage fluid from untreated, prechallenge noses was 400 micrograms/L. (3) The ECP level did not increase during the early phase response. (4) There was a late occurring increase in the ECP concentration (6 to 24 hours). (5) This increase was completely inhibited by budesonide pretreatment. (6) The glucocorticoid therapy also reduced the prechallenge ECP concentration. In conclusion, allergen provocation in the nose results in a late occurring increase of ECP in nasal lavage fluid, and one of the therapeutic effects of topical glucocorticoid therapy may be an inhibition of the allergen-induced increase of this cytotoxic molecule. It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Twenty grass-pollen sensitive volunteers were provoked outside the pollen season on 2 consecutive days after pretreatment for 2 weeks with the glucocorticoid, budesonide as a nasal spray (400 μg/day) and with placebo with a double-blind, crossover design. Nasal lavage fluid was repeatedly collected during a 10-hour period to study both early and late-phase responses. 99mTechnetium-albumin was added to the lavage fluid, making it possible to calculate the amount of secretion and the degree of dilution. The results were as follows: (1) There was no correlation between ECP concentration and dilution factor in the individual samples. (2) The mean concentration of ECP in lavage fluid from untreated, prechallenge noses was 400 μg/L. (3) The ECP level did not increase during the early phase response. (4) There was a late occurring increase in the ECP concentration (6 to 24 hours). (5) This increase was completely inhibited by budesonide pretreatment. (6) The glucocorticoid therapy also reduced the prechallenge ECP concentration. In conclusion, allergen provocation in the nose results in a late occurring increase of ECP in nasal lavage fluid, and one of the therapeutic effects of topical glucocorticoid therapy may be an inhibition of the allergen-induced increase of this cytotoxic molecule. It was our aim to study the effect of nasal allergen provocation on the concentration of eosinophil cationic protein (ECP) in nasal lavage fluid, with and without glucocorticoid pretreatment. Allergen provocation in the nose results in a late occurring increase of ECP in nasal lavage fluid, and one of the therapeutic effects of topical glucocorticoid therapy may be an inhibition of the allergen-induced increase of this cytotoxic molecule. |
Author | Venge, Per Bisgaard, Hans Dahl, Ronald Lindqvist, Nils Mygind, Niels Grønborg, Henrik |
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relationship to nonspecific hyperreactivily [Abstract] publication-title: J Allergy Clin Immunol contributor: fullname: Gleich – volume: 42 start-page: 35 year: 1980 ident: 10.1016/0091-6749(90)90074-E_BIB3 article-title: Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium publication-title: Lab Invest contributor: fullname: Frigas – volume: 123 start-page: 2925 year: 1979 ident: 10.1016/0091-6749(90)90074-E_BIB2 article-title: Cytotoxic properties of the eosinophil major basic protein publication-title: J Immunol doi: 10.4049/jimmunol.123.6.2925 contributor: fullname: Gleich – ident: 10.1016/0091-6749(90)90074-E_BIB18 – volume: 313 start-page: 65 year: 1985 ident: 10.1016/0091-6749(90)90074-E_BIB15 article-title: Inflammatory mediators in late antigen-induced rhinitis publication-title: N Engl J Med doi: 10.1056/NEJM198507113130201 contributor: fullname: Naclerio – volume: 77 start-page: 246 year: 1986 ident: 10.1016/0091-6749(90)90074-E_BIB10 article-title: Effect of systemic steroids on eosinophils and major basic protein during nasal antigen challenge [Abstract] publication-title: J Allergy Clin Immunol contributor: fullname: Bascom – volume: 77 start-page: 527 year: 1986 ident: 10.1016/0091-6749(90)90074-E_BIB23 article-title: The eosinophil and pathophysiology of asthma publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(86)90341-6 contributor: fullname: Frigas – volume: 138 start-page: 406 year: 1988 ident: 10.1016/0091-6749(90)90074-E_BIB9 article-title: The influx of inflammatory cells into nasal washings during the late response to antigen challenge publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/138.2.406 contributor: fullname: Bascom – volume: 128 start-page: 597 year: 1983 ident: 10.1016/0091-6749(90)90074-E_BIB14 article-title: Mediator release after nasal airway challenge with allergen publication-title: Am Rev Respir Dis contributor: fullname: Naclerio – volume: 28 start-page: 9 year: 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nasal polyps publication-title: Acta Otolaryngol (Stockh) contributor: fullname: Mygind – volume: 78 start-page: 436 year: 1974 ident: 10.1016/0091-6749(90)90074-E_BIB28 article-title: Scanning electron microscopic study of nasal polyps publication-title: Acta Otolaryngol (Stockh) doi: 10.3109/00016487409126377 contributor: fullname: Mygind – volume: 42 start-page: 583 year: 1988 ident: 10.1016/0091-6749(90)90074-E_BIB11 article-title: Eosinophil cationic protein and myeloperoxidase in nasal secretion as markers of inflammation in allergic rhinitis publication-title: Allergy doi: 10.1111/j.1398-9995.1987.tb00388.x contributor: fullname: Linder – volume: 79 start-page: 128 year: 1987 ident: 10.1016/0091-6749(90)90074-E_BIB25 article-title: A clinical and pathological study of chronic sinusitis: the role of the eosinophil publication-title: J Allergy Clin Immunol contributor: fullname: Harlin – volume: 16 start-page: 289 year: 1986 ident: 10.1016/0091-6749(90)90074-E_BIB20 article-title: The effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance, and nasal secretions in humans publication-title: Clin Allergy doi: 10.1111/j.1365-2222.1986.tb01960.x contributor: fullname: Bisgaard – volume: 77 start-page: 236 year: 1986 ident: 10.1016/0091-6749(90)90074-E_BIB21 article-title: Eosinophil and major basic protein in bronchoalveolar lavage in asthma: relationship to nonspecific hyperreactivily [Abstract] publication-title: J Allergy Clin Immunol contributor: fullname: Kay – volume: 12 start-page: 131 year: 1974 ident: 10.1016/0091-6749(90)90074-E_BIB17 article-title: Histology of nasal mucosa in normals and in patients with perennial rhinitis: a blind study of plastic-embedded specimens publication-title: Rhinology contributor: fullname: Mygind – volume: 37 start-page: 331 year: 1977 ident: 10.1016/0091-6749(90)90074-E_BIB13 article-title: Radioimmunoassay of human eosinophil cationic protein publication-title: Br J Haematol doi: 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start-page: 11 year: 1982 ident: 10.1016/0091-6749(90)90074-E_BIB5 article-title: Identification by immunofluorescence of eosinophil granule major basic protein in lung tissue of patients with bronchial asthma publication-title: Lancet doi: 10.1016/S0140-6736(82)91152-7 contributor: fullname: Filley – volume: 81 start-page: 776 year: 1988 ident: 10.1016/0091-6749(90)90074-E_BIB8 article-title: The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(88)90931-1 contributor: fullname: Gleich – volume: 138 start-page: 54 year: 1988 ident: 10.1016/0091-6749(90)90074-E_BIB4 article-title: Epithelial injury by human eosinophils publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/138.6_Pt_2.S54 contributor: fullname: Venge – volume: 43 start-page: 219 year: 1988 ident: 10.1016/0091-6749(90)90074-E_BIB16 article-title: Leukotriene C4 and histamine in the early allergic reaction in the nose publication-title: Allergy doi: 10.1111/j.1398-9995.1988.tb00422.x contributor: fullname: Bisgaard – volume: 14 start-page: 241 year: 1984 ident: 10.1016/0091-6749(90)90074-E_BIB26 article-title: Epithelial damage in nasal polyps publication-title: Clin Allergy doi: 10.1111/j.1365-2222.1984.tb02203.x contributor: fullname: Wladislavosky-Waserman – volume: 131 start-page: 373 year: 1985 ident: 10.1016/0091-6749(90)90074-E_BIB7 article-title: Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions publication-title: Am Rev Respir Dis contributor: fullname: de Monchy |
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SubjectTerms | Adult Biological and medical sciences Blood Proteins - analysis Budesonide Clinical Trials as Topic Double-Blind Method Eosinophil Granule Proteins Female Humans Immunopathology Male Medical sciences Nasal Mucosa - metabolism Pregnenediones - pharmacology Pregnenediones - therapeutic use Rhinitis, Allergic, Perennial - drug therapy Ribonucleases Therapeutic Irrigation |
Title | Allergen-induced increase of eosinophil cationic protein in nasal lavage fluid: Effect of the glucocorticoid budesonide |
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