Measles Vaccine Strains for Virotherapy of Non–Small-Cell Lung Carcinoma

• Published in: Journal of thoracic oncology Vol. 9; no. 8; pp. 1101 - 1110
• Main Authors: Patel, Manish R., Jacobson, Blake A., Belgum, Holly, Raza, Ahmad, Sadiq, Ahad, Drees, Jeremy, Wang, Hengbing, Jay-Dixon, Joseph, Etchison, Ryan, Federspiel, Mark J., Russell, Stephen J., Kratzke, Robert A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Antimetabolites, Antineoplastic - pharmacology; Apoptosis; Carcinoembryonic Antigen - drug effects; Carcinoembryonic Antigen - genetics; Carcinoembryonic Antigen - metabolism; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cell Adhesion Molecules - antagonists & inhibitors; Cell Adhesion Molecules - metabolism; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival - drug effects; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; Epithelial Cells - virology; Eukaryotic Initiation Factor-4E - metabolism; Gemcitabine; Green Fluorescent Proteins - genetics; Humans; Hydrazones - pharmacology; Lung; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Measles Vaccine; Measles virus; Measles virus - genetics; Measles virus - physiology; Membrane Cofactor Protein - antagonists & inhibitors; Membrane Cofactor Protein - metabolism; Mice; Non–small-cell lung cancer; Oncolytic Virotherapy; Phosphoproteins - metabolism; Sirolimus - pharmacology; Thiazoles - pharmacology; Translation; Tumor Burden; Virus Replication; Non–small-cell lung cancer; Translation; Measles virus

Oncolytic virus therapy is a promising therapy for numerous tumor types. Edmonston-strain measles virus (MV) has been tested in clinical trials for ovarian cancer, glioma, and myeloma. Therefore, the antitumor activity of MV against non–small-cell lung cancer (NSCLC) was assessed. Human NSCLC cells...