Botulinum toxin in masticatory muscles of the adult rat induces bone loss at the condyle and alveolar regions of the mandible associated with a bone proliferation at a muscle enthesis

• Published in: Bone (New York, N.Y.) Vol. 77; pp. 75 - 82
• Main Authors: Kün-Darbois, Jean-Daniel, Libouban, Hélène, Chappard, Daniel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2015; Elsevier
• Subjects: Animals; Botulinum toxin; Botulinum Toxins - pharmacology; Disuse osteoporosis; Life Sciences; Male; Mandible; Mandibular Condyle - pathology; Masticatory muscles; Masticatory Muscles - drug effects; Orthopedics; Osteoporosis - pathology; Rats; Rats, Sprague-Dawley; Torus mandibularis; X-Ray Microtomography; Mandible; Disuse osteoporosis; Masticatory muscles; Botulinum toxin; Torus mandibularis

In man, botulinum toxin type A (BTX) is injected in masticatory muscles for several indications such as trismus, bruxism, or masseter hypertrophy. Bone changes in the mandible following BTX injections in adult animal have therefore became a subject of interest. The aim of this study was to analyze c...