Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment

• Published in: European journal of clinical nutrition Vol. 71; no. 1; pp. 45 - 50
• Main Authors: Jaiswal, S K, Sukla, K K, Chauhan, A, Lakhotia, A R, Kumar, A, Rai, A K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2017; Nature Publishing Group
• Subjects: 45; 45/22; 45/29; 45/77; 692/499; Adult; Betaine-Homocysteine S-Methyltransferase - genetics; Case-Control Studies; Child; Choline; Choline - metabolism; Choline Dehydrogenase - genetics; Clinical Nutrition; Dehydrogenase; Down syndrome; Down Syndrome - genetics; Epidemiology; Female; Folic acid; Folic Acid - metabolism; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genotype; Health aspects; Homocysteine; Homocysteine - metabolism; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic Networks and Pathways - genetics; Metabolism; Mothers; Nutrients; Odds Ratio; original-article; Phosphatidylethanolamine N-Methyltransferase - genetics; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Public Health; Risk Factors; India

Background/objectives: Choline is an essential nutrient involved in one-carbon metabolism, but its role in mechanisms underlying meiotic non-disjunction is poorly known. The relationship between folate-homocysteine metabolic pathway gene polymorphism and Down syndrome (DS) risk has been widely analy...