Autoantibodies in the diagnosis, prognosis, and prediction of colorectal cancer

Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. Early diagnosis improves prognosis and long-term outcomes. Several studies have found tumor-associated autoantibodies in CRC patients. We aimed to provide an overview on CRC-associated autoantibodies and their reported d...

Full description

Saved in:
Bibliographic Details
Published inJournal of cancer research and therapeutics Vol. 17; no. 4; pp. 819 - 833
Main Authors Niloofa, Roshan, De Zoysa, M, Seneviratne, L
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.07.2021
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Subjects
Animals
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Biological markers
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - immunology
Diagnosis
Health aspects
Humans
Prognosis
Risk factors
Sri Lanka
Anti-p53
colorectal cancer
early detection
tumor-associated antigen
autoantibodies
prognosis
Online AccessGet full text

Cover

Abstract Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. Early diagnosis improves prognosis and long-term outcomes. Several studies have found tumor-associated autoantibodies in CRC patients. We aimed to provide an overview on CRC-associated autoantibodies and their reported diagnostic, prognostic, and predictive performance when used singly or in combination. We systematically reviewed studies on CRC-related autoantibodies published till March 2018 and critically analyzed the role of these autoantibodies in CRC. In general, autoantibodies were of low sensitivity when tested individually and the diagnostic characteristics improved when tested in combination. Autoantibodies against CCD83, carcinoembryonic antigen, MAPKAPK3, RPH 3AL, SEC61b, and SPAG9 showed high sensitivity and specificity when tested alone. When tested in combination, autoantibodies against three antigens (PIM1, MAPKAPK3, and ACVR2B) showed high sensitivity and specificity. So far, most CRC-associated autoantibodies have been evaluated in single or in a small number of studies. In contrast, anti-p53 antibodies have been studied in a larger number of CRC studies, but, so far, none of them have high diagnostic characteristics. CRC-associated autoantibodies are detectable from the early stages of malignancy, pointing to their possible use in the early detection of CRC. Some studies suggest that CRC-associated autoantibodies may be a guide to prognosis in CRC.
AbstractList Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. Early diagnosis improves prognosis and long-term outcomes. Several studies have found tumor-associated autoantibodies in CRC patients. We aimed to provide an overview on CRC-associated autoantibodies and their reported diagnostic, prognostic, and predictive performance when used singly or in combination. We systematically reviewed studies on CRC-related autoantibodies published till March 2018 and critically analyzed the role of these autoantibodies in CRC. In general, autoantibodies were of low sensitivity when tested individually and the diagnostic characteristics improved when tested in combination. Autoantibodies against CCD83, carcinoembryonic antigen, MAPKAPK3, RPH 3AL, SEC61b, and SPAG9 showed high sensitivity and specificity when tested alone. When tested in combination, autoantibodies against three antigens (PIM1, MAPKAPK3, and ACVR2B) showed high sensitivity and specificity. So far, most CRC-associated autoantibodies have been evaluated in single or in a small number of studies. In contrast, anti-p53 antibodies have been studied in a larger number of CRC studies, but, so far, none of them have high diagnostic characteristics. CRC-associated autoantibodies are detectable from the early stages of malignancy, pointing to their possible use in the early detection of CRC. Some studies suggest that CRC-associated autoantibodies may be a guide to prognosis in CRC.
Audience Professional
Author De Zoysa, M
Seneviratne, L
Niloofa, Roshan
Author_xml – sequence: 1
  givenname: Roshan
  surname: Niloofa
  fullname: Niloofa, Roshan
  organization: Department of Zoology and Environmental Sciences, Faculty of Science, University of Colombo, Colombo
– sequence: 2
  givenname: M
  surname: De Zoysa
  fullname: De Zoysa, M
  organization: Department of Surgery, Faculty of Medicine, University of Colombo, Colombo
– sequence: 3
  givenname: L
  surname: Seneviratne
  fullname: Seneviratne, L
  organization: Department of Zoology and Environmental Sciences, Faculty of Science, University of Colombo, Colombo
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34528528$$D View this record in MEDLINE/PubMed
BookMark eNp1kktrGzEUhUVJaRy36-7KQDdZdBy9ZkZaGtMngUBI1kIj3XHlyFIqzWD67yPjuKHFRRJ68J3DlY4u0FmIARB6T_CCE8yuNiaNix-r2zvVckXkKzQjUoqaEybO0AzLjtWEC3qOLnLeYNx0lIo36JzxhorSZ-hmOY1Rh9H10TrIlQvV-BMq6_Q6xOzyp-oxxeNSB1u2YJ0ZXQxVHCoTfUxgRu0ro4OB9Ba9HrTP8O55nqP7L5_vVt_q65uv31fL69o0VLq664EKAyAx12zopBYaJBGsHbAVtie6YUApadue9EIwhhmnxAC3zMqBwMDm6PLgW8r7NUEe1dZlA97rAHHKijYd45zK8gJz9PEfdBOnFEp1e4p3tHjjF2qtPSgXhjgmbfamatl2jRBEtLRQ9QlqDQGS9iWawZXjv_jFCb40C1tnTgquDgKTYs4JBvWY3Fan34pgtY9c7SNXL5EXxYfn6039Fuwf_phxAZYHYBf9CCk_-GkHSRX2IcTd_3yVKOP4OdgTzN2_Gw
CitedBy_id crossref_primary_10_1111_cas_16011
crossref_primary_10_3389_fimmu_2023_1277597
crossref_primary_10_1016_j_smim_2024_101874
crossref_primary_10_1007_s13273_023_00348_z
crossref_primary_10_4103_jcrt_jcrt_2670_22
crossref_primary_10_4103_jcrt_jcrt_919_23
crossref_primary_10_3390_cancers14153562
Cites_doi 10.1002/(SICI)1097-0215(19970106)70:1<46::AID-IJC7>3.0.CO;2-6
10.1016/j.cca.2011.04.020
10.1002/pmic.200300594
10.18632/oncotarget.7500
10.1038/bjc.1995.386
10.1007/s003840000263
10.3892/ol.2012.734
10.1038/ajg.2013.424
10.1023/A:1005473729976
10.1007/s12014-009-9031-6
10.1158/0008-5472.CAN-12-1656
10.1016/j.canlet.2014.01.007
10.1586/egh.12.12
10.1016/j.bbrc.2011.02.077
10.1159/000449527
10.1177/147323001103900317
10.1016/j.canlet.2008.01.013
10.1007/BF02065426
10.1007/BF02171705
10.1158/1055-9965.EPI-17-0407
10.1007/s005350050096
10.1515/CCLM.2010.123
10.1016/j.cdp.2005.03.002
10.18632/oncotarget.12696
10.1007/BF01540984
10.1186/1471-230X-6-4
10.1111/j.1572-0241.2000.01982.x
10.3892/mco.2017.1368
10.1016/j.cca.2011.01.012
10.1371/journal.pone.0123469
10.1080/110241501750069828
10.1002/ijc.24912
10.1002/ijc.1541
10.3892/ijo.2012.1601
10.1016/j.cca.2017.10.022
10.1016/j.molimm.2008.12.025
10.1074/mcp.M800596-MCP200
10.2353/ajpath.2010.091178
10.1002/cncr.11092
10.1006/clim.2001.5048
10.3109/1354750X.2012.677476
10.1007/s002620050536
10.1158/1078-0432.CCR-07-2021
10.1097/MCG.0b013e3181e880ee
10.1111/j.1365-3083.2008.02195.x
10.1007/s00384-008-0458-4
10.1016/j.bbrc.2005.02.181
10.1002/ijc.21240
10.1111/sji.12032
10.1007/s00384-009-0759-2
10.1136/gut.40.3.356
10.1016/j.ajpath.2010.11.047
10.1093/annonc/mds007
10.1186/1471-2407-12-520
10.1002/prca.200600718
10.3322/caac.21332
10.1007/s00384-003-0553-5
10.1038/bjc.2012.517
10.1158/1078-0432.CCR-11-0199
10.1002/ijc.2910460109
10.1002/ijc.25778
10.1371/journal.pone.0156971
10.1074/mcp.M110.001784
ContentType Journal Article
Copyright COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.
2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2021 Medknow Publications and Media Pvt. Ltd.
– notice: 2021. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
DOI 10.4103/jcrt.JCRT_64_19
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Research Library
Research Library (Corporate)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database
MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
EISSN 1998-4138
EndPage 833
ExternalDocumentID A675881862
10_4103_jcrt_JCRT_64_19
34528528
10.4103/jcrt.JCRT_64_19_819_Autoanti
Genre Journal Article
Review
GeographicLocations Sri Lanka
GeographicLocations_xml – name: Sri Lanka
GroupedDBID -
29K
2WC
3V.
53G
5GY
5VS
7X7
8FI
8G5
AAWTL
ABDBF
ABPTK
ABUWG
ACGFS
ADACO
ADBBV
AENEX
AFKRA
AHMBA
ALMA_UNASSIGNED_HOLDINGS
AZQEC
BAWUL
BBAFP
BCNDV
BENPR
BPHCQ
BVXVI
D-I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
EOJEC
ESX
F5P
FYUFA
GROUPED_DOAJ
GUQSH
GX1
IAO
IEA
IHR
INH
INR
IOF
IPO
ITC
KQ8
LI0
M1P
M2O
M~E
OBODZ
OK1
P2P
PADUT
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PROAC
PSQYO
RBI
RIG
RMW
RNS
SV3
TR2
TUS
W3E
XSB
---
88E
8FJ
ABJNI
ABXLX
ALIPV
CCPQU
CGR
CUY
CVF
ECM
EIF
EMOBN
GNUQQ
H13
HMCUK
IHE
IL9
IPNFZ
NPM
OVD
P6G
TEORI
UKHRP
~8M
AAYXX
CITATION
7XB
8FK
K9.
MBDVC
Q9U
7X8
ID FETCH-LOGICAL-c529i-7be28cee904a3f79a8ae91836f0d8db1a53e22166b1b883303421ce4d3d9f1ef3
IEDL.DBID W3E
ISSN 0973-1482
IngestDate Thu Oct 24 23:32:09 EDT 2024
Thu Oct 10 21:13:42 EDT 2024
Thu Feb 22 23:24:54 EST 2024
Fri Feb 02 04:43:07 EST 2024
Fri Feb 02 04:10:23 EST 2024
Wed Oct 23 14:28:51 EDT 2024
Sat Sep 28 08:22:26 EDT 2024
Wed Sep 22 12:55:22 EDT 2021
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Anti-p53
colorectal cancer
early detection
tumor-associated antigen
autoantibodies
prognosis
Language English
License http://creativecommons.org/licenses/by-nc-sa/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c529i-7be28cee904a3f79a8ae91836f0d8db1a53e22166b1b883303421ce4d3d9f1ef3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2021;volume=17;issue=4;spage=819;epage=833;aulast=Niloofa;type=0
PMID 34528528
PQID 2574723420
PQPubID 226490
PageCount 15
ParticipantIDs proquest_miscellaneous_2573442997
proquest_journals_2574723420
gale_infotracmisc_A675881862
gale_infotracgeneralonefile_A675881862
gale_infotracacademiconefile_A675881862
crossref_primary_10_4103_jcrt_JCRT_64_19
pubmed_primary_34528528
wolterskluwer_medknow_10_4103_jcrt_JCRT_64_19_819_Autoanti
ProviderPackageCode W3E
RMW
PublicationCentury 2000
PublicationDate 20210701
PublicationDateYYYYMMDD 2021-07-01
PublicationDate_xml – month: 7
  year: 2021
  text: 20210701
  day: 01
PublicationDecade 2020
PublicationPlace India
PublicationPlace_xml – name: India
– name: Mumbai
PublicationTitle Journal of cancer research and therapeutics
PublicationTitleAlternate J Cancer Res Ther
PublicationYear 2021
Publisher Wolters Kluwer India Pvt. Ltd
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Publisher_xml – name: Wolters Kluwer India Pvt. Ltd
– name: Medknow Publications and Media Pvt. Ltd
– name: Medknow Publications & Media Pvt. Ltd
References Fan (R43-1-20241021) 2011; 412
Xu (R34-1-20241021) 2012; 72
Chang (R57-1-20241021) 2011; 17
Konstadoulakis (R21-1-20241021) 1994; 14
Houbiers (R77-1-20241021) 1995; 72
Lee (R3-1-20241021) 2012; 6
Kojima (R56-1-20241021) 2009; 2
Takahashi (R41-1-20241021) 1995; 1
Chang (R71-1-20241021) 2005; 26
Koziol (R53-1-20241021) 2003; 9
Ran (R55-1-20241021) 2008; 14
Zhang (R15-1-20241021) 2003; 12
Megliorino (R47-1-20241021) 2005; 29
Chen (R45-1-20241021) 2010; 48
Teras (R76-1-20241021) 2018; 27
Suppiah (R72-1-20241021) 2008; 23
Liu (R39-1-20241021) 2013; 77
Chen (R42-1-20241021) 2011; 412
Pedersen (R74-1-20241021) 2013; 108
Nakamura (R36-1-20241021) 1998; 33
Tang (R67-1-20241021) 2001; 94
Chen (R6-1-20241021) 2012; 4
Mosolits (R23-1-20241021) 1999; 47
Chan (R17-1-20241021) 2010; 126
He (R29-1-20241021) 2007; 1
Angelopoulou (R62-1-20241021) 1997; 70
Negm (R7-1-20241021) 2016; 11
Hanafusa (R48-1-20241021) 2012; 12
Abe (R78-1-20241021) 2017; 92
Song (R18-1-20241021) 2012; 41
Shiota (R65-1-20241021) 2000; 45
He (R32-1-20241021) 2009; 24
Liu (R13-1-20241021) 2009; 69
Wu (R19-1-20241021) 2011; 39
Wu (R73-1-20241021) 2011; 12
Siegel (R1-1-20241021) 2016; 66
Zhang (R33-1-20241021) 2001; 100
Ben-Mahrez (R16-1-20241021) 1990; 46
Lechpammer (R70-1-20241021) 2004; 19
Kumamoto (R75-1-20241021) 2017; 7
Silk (R35-1-20241021) 2009; 47
Chen (R79-1-20241021) 2014; 346
Pedersen (R37-1-20241021) 2011; 128
Babel (R5-1-20241021) 2009; 8
Takeda (R66-1-20241021) 2001; 167
Kobayashi (R40-1-20241021) 2016; 7
Shimada (R69-1-20241021) 2003; 97
Hammel (R61-1-20241021) 1997; 40
Hallak (R63-1-20241021) 1998; 12
Song (R11-1-20241021) 2011; 408
Fan (R60-1-20241021) 2017; 475
Rimm (R51-1-20241021) 1995; 40
Kojima (R58-1-20241021) 2011; 19
Kanojia (R44-1-20241021) 2011; 178
Tsunemi (R25-1-20241021) 2010; 23
Müller (R54-1-20241021) 2006; 29
Looi (R14-1-20241021) 2006; 16
Syrigos (R49-1-20241021) 1999; 18
Albanopoulos (R20-1-20241021) 2000; 95
Chen (R9-1-20241021) 2011; 45
O'Reilly (R52-1-20241021) 2015; 10
Bielicki (R64-1-20241021) 1999; 50
Kamei (R28-1-20241021) 1992; 4
Shebzukhov (R26-1-20241021) 2005; 117
Scanlan (R27-1-20241021) 2002; 62
Kocer (R38-1-20241021) 2006; 6
Kiyamova (R4-1-20241021) 2012; 17
Broll (R68-1-20241021) 2001; 16
Brenner (R2-1-20241021) 2014; 109
Jiang (R10-1-20241021) 2010; 177
Babel (R24-1-20241021) 2011; 10
Nam (R50-1-20241021) 2003; 3
Fujita (R30-1-20241021) 2008; 263
Xia (R22-1-20241021) 2005; 330
Rohayem (R46-1-20241021) 2000; 60
Chen (R59-1-20241021) 2016; 7
Chen (R12-1-20241021) 2007; 30
Song (R8-1-20241021) 2009; 5
Li (R31-1-20241021) 2012; 23
References_xml – volume: 70
  start-page: 46
  year: 1997
  ident: R62-1-20241021
  article-title: Humoral immune response against p53 protein in patients with colorectal carcinoma
  publication-title: Int J Cancer
  doi: 10.1002/(SICI)1097-0215(19970106)70:1<46::AID-IJC7>3.0.CO;2-6
  contributor:
    fullname: Angelopoulou
– volume: 412
  start-page: 1417
  year: 2011
  ident: R42-1-20241021
  article-title: Detection of autoantibodies against rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2011.04.020
  contributor:
    fullname: Chen
– volume: 3
  start-page: 2108
  year: 2003
  ident: R50-1-20241021
  article-title: Molecular profiling of the immune response in colon cancer using protein microarrays: Occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3
  publication-title: Proteomics
  doi: 10.1002/pmic.200300594
  contributor:
    fullname: Nam
– volume: 7
  start-page: 16420
  year: 2016
  ident: R59-1-20241021
  article-title: Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7500
  contributor:
    fullname: Chen
– volume: 1
  start-page: 1071
  year: 1995
  ident: R41-1-20241021
  article-title: Antibody to ras proteins in patients with colon cancer
  publication-title: Clin Cancer Res
  contributor:
    fullname: Takahashi
– volume: 72
  start-page: 637
  year: 1995
  ident: R77-1-20241021
  article-title: Antibodies against p53 are associated with poor prognosis of colorectal cancer
  publication-title: Br J Cancer
  doi: 10.1038/bjc.1995.386
  contributor:
    fullname: Houbiers
– volume: 16
  start-page: 22
  year: 2001
  ident: R68-1-20241021
  article-title: P53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s003840000263
  contributor:
    fullname: Broll
– volume: 4
  start-page: 319
  year: 2012
  ident: R6-1-20241021
  article-title: Serum anti-AEG-1 auto-antibody is a potential novel biomarker for malignant tumors
  publication-title: Oncol Lett
  doi: 10.3892/ol.2012.734
  contributor:
    fullname: Chen
– volume: 109
  start-page: 427
  year: 2014
  ident: R2-1-20241021
  article-title: Diagnostic performance of guaiac-based fecal occult blood test in routine screening: State-wide analysis from Bavaria, Germany
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2013.424
  contributor:
    fullname: Brenner
– volume: 45
  start-page: 122
  year: 2000
  ident: R65-1-20241021
  article-title: Circulating p53 antibody in patients with colorectal cancer: Relation to clinicopathologic features and survival
  publication-title: Dig Dis Sci
  doi: 10.1023/A:1005473729976
  contributor:
    fullname: Shiota
– volume: 50
  start-page: 77
  year: 1999
  ident: R64-1-20241021
  article-title: Clinico-pathological characteristics of colorectal cancer and serum anti-p53 antibodies
  publication-title: Pol J Pathol
  contributor:
    fullname: Bielicki
– volume: 5
  start-page: 7
  year: 2009
  ident: R8-1-20241021
  article-title: Detection of autoantibodies to annexin A11 in different types of human cancer
  publication-title: Clin Proteomics
  doi: 10.1007/s12014-009-9031-6
  contributor:
    fullname: Song
– volume: 72
  start-page: 6351
  year: 2012
  ident: R34-1-20241021
  article-title: An integrated genome-wide approach to discover tumor-specific antigens as potential immunologic and clinical targets in cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-12-1656
  contributor:
    fullname: Xu
– volume: 346
  start-page: 178
  year: 2014
  ident: R79-1-20241021
  article-title: Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2014.01.007
  contributor:
    fullname: Chen
– volume: 62
  start-page: 4041
  year: 2002
  ident: R27-1-20241021
  article-title: Cancer-related serological recognition of human colon cancer: Identification of potential diagnostic and immunotherapeutic targets
  publication-title: Cancer Res
  contributor:
    fullname: Scanlan
– volume: 6
  start-page: 301
  year: 2012
  ident: R3-1-20241021
  article-title: Screening for colorectal cancer: What fits best?
  publication-title: Expert Rev Gastroenterol Hepatol
  doi: 10.1586/egh.12.12
  contributor:
    fullname: Lee
– volume: 23
  start-page: 949
  year: 2010
  ident: R25-1-20241021
  article-title: Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer
  publication-title: Oncol Rep
  contributor:
    fullname: Tsunemi
– volume: 9
  start-page: 5120
  year: 2003
  ident: R53-1-20241021
  article-title: Recursive partitioning as an approach to selection of immune markers for tumor diagnosis
  publication-title: Clin Cancer Res
  contributor:
    fullname: Koziol
– volume: 12
  start-page: 2921
  year: 2011
  ident: R73-1-20241021
  article-title: Detection of serum anti-P53 antibodies from patients with colorectal cancer in China using a combination of P53 – And phage-ELISA: Correlation to clinical parameters
  publication-title: Asian Pac J Cancer Prev
  contributor:
    fullname: Wu
– volume: 408
  start-page: 195
  year: 2011
  ident: R11-1-20241021
  article-title: Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2011.02.077
  contributor:
    fullname: Song
– volume: 92
  start-page: 31
  year: 2017
  ident: R78-1-20241021
  article-title: Prognostic value of pre- and postoperative anti-p53 antibody levels in colorectal cancer patients: A Retrospective study
  publication-title: Oncology
  doi: 10.1159/000449527
  contributor:
    fullname: Abe
– volume: 39
  start-page: 838
  year: 2011
  ident: R19-1-20241021
  article-title: Circulating antibodies to carcinoembryonic antigen related to improved recurrence-free survival of patients with colorectal carcinoma
  publication-title: J Int Med Res
  doi: 10.1177/147323001103900317
  contributor:
    fullname: Wu
– volume: 60
  start-page: 1815
  year: 2000
  ident: R46-1-20241021
  article-title: Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients
  publication-title: Cancer Res
  contributor:
    fullname: Rohayem
– volume: 263
  start-page: 280
  year: 2008
  ident: R30-1-20241021
  article-title: Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2008.01.013
  contributor:
    fullname: Fujita
– volume: 40
  start-page: 389
  year: 1995
  ident: R51-1-20241021
  article-title: Autoantibodies specific for villin found in patients with colon cancer and other colitides
  publication-title: Dig Dis Sci
  doi: 10.1007/BF02065426
  contributor:
    fullname: Rimm
– volume: 4
  start-page: 17
  year: 1992
  ident: R28-1-20241021
  article-title: Serodiagnosis of cancers by ELISA of anti-histone H2B antibody
  publication-title: Biotherapy
  doi: 10.1007/BF02171705
  contributor:
    fullname: Kamei
– volume: 27
  start-page: 219
  year: 2018
  ident: R76-1-20241021
  article-title: Prediagnostic antibodies to serum p53 and subsequent colorectal cancer
  publication-title: Cancer Epidemiol Biomarkers Prev
  doi: 10.1158/1055-9965.EPI-17-0407
  contributor:
    fullname: Teras
– volume: 30
  start-page: 1137
  year: 2007
  ident: R12-1-20241021
  article-title: Autoantibodies to Ca2+binding protein calnuc is a potential marker in colon cancer detection
  publication-title: Int J Oncol
  contributor:
    fullname: Chen
– volume: 33
  start-page: 354
  year: 1998
  ident: R36-1-20241021
  article-title: Detection of circulating anti-MUC1 mucin core protein antibodies in patients with colorectal cancer
  publication-title: J Gastroenterol
  doi: 10.1007/s005350050096
  contributor:
    fullname: Nakamura
– volume: 48
  start-page: 719
  year: 2010
  ident: R45-1-20241021
  article-title: Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer
  publication-title: Clin Chem Lab Med
  doi: 10.1515/CCLM.2010.123
  contributor:
    fullname: Chen
– volume: 29
  start-page: 241
  year: 2005
  ident: R47-1-20241021
  article-title: Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection
  publication-title: Cancer Detect Prev
  doi: 10.1016/j.cdp.2005.03.002
  contributor:
    fullname: Megliorino
– volume: 7
  start-page: 82493
  year: 2016
  ident: R40-1-20241021
  article-title: Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12696
  contributor:
    fullname: Kobayashi
– volume: 29
  start-page: 973
  year: 2006
  ident: R54-1-20241021
  article-title: Testing for anti-p53 antibodies increases the diagnostic sensitivity of conventional tumor markers
  publication-title: Int J Oncol
  contributor:
    fullname: Müller
– volume: 14
  start-page: 310
  year: 1994
  ident: R21-1-20241021
  article-title: The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies
  publication-title: J Clin Immunol
  doi: 10.1007/BF01540984
  contributor:
    fullname: Konstadoulakis
– volume: 6
  start-page: 4
  year: 2006
  ident: R38-1-20241021
  article-title: Humoral immune response to MUC5AC in patients with colorectal polyps and colorectal carcinoma
  publication-title: BMC Gastroenterol
  doi: 10.1186/1471-230X-6-4
  contributor:
    fullname: Kocer
– volume: 95
  start-page: 1056
  year: 2000
  ident: R20-1-20241021
  article-title: Prognostic significance of circulating antibodies against carcinoembryonic antigen (anti-CEA) in patients with colon cancer
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2000.01982.x
  contributor:
    fullname: Albanopoulos
– volume: 7
  start-page: 595
  year: 2017
  ident: R75-1-20241021
  article-title: Clinical significance of serum anti-p53 antibody expression following curative surgery for colorectal cancer
  publication-title: Mol Clin Oncol
  doi: 10.3892/mco.2017.1368
  contributor:
    fullname: Kumamoto
– volume: 412
  start-page: 887
  year: 2011
  ident: R43-1-20241021
  article-title: Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2011.01.012
  contributor:
    fullname: Fan
– volume: 10
  start-page: e0123469
  year: 2015
  ident: R52-1-20241021
  article-title: Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0123469
  contributor:
    fullname: O'Reilly
– volume: 167
  start-page: 50
  year: 2001
  ident: R66-1-20241021
  article-title: Monitoring of p53 autoantibodies after resection of colorectal cancer: Relationship to operative curability
  publication-title: Eur J Surg
  doi: 10.1080/110241501750069828
  contributor:
    fullname: Takeda
– volume: 126
  start-page: 1683
  year: 2010
  ident: R17-1-20241021
  article-title: Multiple serological biomarkers for colorectal cancer detection
  publication-title: Int J Cancer
  doi: 10.1002/ijc.24912
  contributor:
    fullname: Chan
– volume: 94
  start-page: 859
  year: 2001
  ident: R67-1-20241021
  article-title: Humoral response to p53 in human colorectal tumors: A prospective study of 1,209 patients
  publication-title: Int J Cancer
  doi: 10.1002/ijc.1541
  contributor:
    fullname: Tang
– volume: 41
  start-page: 1820
  year: 2012
  ident: R18-1-20241021
  article-title: KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon cancer
  publication-title: Int J Oncol
  doi: 10.3892/ijo.2012.1601
  contributor:
    fullname: Song
– volume: 475
  start-page: 157
  year: 2017
  ident: R60-1-20241021
  article-title: Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2017.10.022
  contributor:
    fullname: Fan
– volume: 47
  start-page: 52
  year: 2009
  ident: R35-1-20241021
  article-title: Humoral immune response to abnormal MUC1 in subjects with colorectal adenoma and cancer
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2008.12.025
  contributor:
    fullname: Silk
– volume: 2
  start-page: 477
  year: 2009
  ident: R56-1-20241021
  article-title: Titration of serum CEA, p53 antibodies and CEA-IgM complexes in patients with colorectal cancer
  publication-title: Mol Med Rep
  contributor:
    fullname: Kojima
– volume: 26
  start-page: 65
  year: 2005
  ident: R71-1-20241021
  article-title: Genetic alteration of p53, but not overexpression of intratumoral p53 protein, or serum p53 antibody is a prognostic factor in sporadic colorectal adenocarcinoma
  publication-title: Int J Oncol
  contributor:
    fullname: Chang
– volume: 8
  start-page: 2382
  year: 2009
  ident: R5-1-20241021
  article-title: Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M800596-MCP200
  contributor:
    fullname: Babel
– volume: 16
  start-page: 1105
  year: 2006
  ident: R14-1-20241021
  article-title: Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies
  publication-title: Oncol Rep
  contributor:
    fullname: Looi
– volume: 177
  start-page: 1095
  year: 2010
  ident: R10-1-20241021
  article-title: Peptide mimic isolated by autoantibody reveals human arrest defective 1 overexpression is associated with poor prognosis for colon cancer patients
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2010.091178
  contributor:
    fullname: Jiang
– volume: 97
  start-page: 682
  year: 2003
  ident: R69-1-20241021
  article-title: Japan p53 Antibody Research Group. Titration of serum p53 antibodies in 1,085 patients with various types of malignant tumors: A multiinstitutional analysis by the Japan p53 Antibody Research Group
  publication-title: Cancer
  doi: 10.1002/cncr.11092
  contributor:
    fullname: Shimada
– volume: 100
  start-page: 149
  year: 2001
  ident: R33-1-20241021
  article-title: Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies
  publication-title: Clin Immunol
  doi: 10.1006/clim.2001.5048
  contributor:
    fullname: Zhang
– volume: 17
  start-page: 362
  year: 2012
  ident: R4-1-20241021
  article-title: Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers
  publication-title: Biomarkers
  doi: 10.3109/1354750X.2012.677476
  contributor:
    fullname: Kiyamova
– volume: 47
  start-page: 315
  year: 1999
  ident: R23-1-20241021
  article-title: Autoantibodies against the tumour-associated antigen GA733-2 in patients with colorectal carcinoma
  publication-title: Cancer Immunol Immunother
  doi: 10.1007/s002620050536
  contributor:
    fullname: Mosolits
– volume: 14
  start-page: 2696
  year: 2008
  ident: R55-1-20241021
  article-title: Profiling tumor-associated autoantibodies for the detection of colon cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-07-2021
  contributor:
    fullname: Ran
– volume: 45
  start-page: 125
  year: 2011
  ident: R9-1-20241021
  article-title: Detection of annexin A autoantibodies in sera from colorectal cancer patients
  publication-title: J Clin Gastroenterol
  doi: 10.1097/MCG.0b013e3181e880ee
  contributor:
    fullname: Chen
– volume: 69
  start-page: 57
  year: 2009
  ident: R13-1-20241021
  article-title: Evaluation of tumour-associated antigen (TAA) miniarray in immunodiagnosis of colon cancer
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.2008.02195.x
  contributor:
    fullname: Liu
– volume: 12
  start-page: 136
  year: 2003
  ident: R15-1-20241021
  article-title: Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens
  publication-title: Cancer Epidemiol Biomarkers Prev
  contributor:
    fullname: Zhang
– volume: 23
  start-page: 595
  year: 2008
  ident: R72-1-20241021
  article-title: Anti-p53 autoantibody in colorectal cancer: Prognostic significance in long-term follow-up
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s00384-008-0458-4
  contributor:
    fullname: Suppiah
– volume: 330
  start-page: 526
  year: 2005
  ident: R22-1-20241021
  article-title: Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2005.02.181
  contributor:
    fullname: Xia
– volume: 117
  start-page: 800
  year: 2005
  ident: R26-1-20241021
  article-title: Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients
  publication-title: Int J Cancer
  doi: 10.1002/ijc.21240
  contributor:
    fullname: Shebzukhov
– volume: 77
  start-page: 255
  year: 2013
  ident: R39-1-20241021
  article-title: Humoral autoimmune response to IGF2 mRNA-binding protein (IMP2/p62) and its tissue-specific expression in colon cancer
  publication-title: Scand J Immunol
  doi: 10.1111/sji.12032
  contributor:
    fullname: Liu
– volume: 24
  start-page: 1271
  year: 2009
  ident: R32-1-20241021
  article-title: Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s00384-009-0759-2
  contributor:
    fullname: He
– volume: 40
  start-page: 356
  year: 1997
  ident: R61-1-20241021
  article-title: Detection and monitoring of serum p53 antibodies in patients with colorectal cancer
  publication-title: Gut
  doi: 10.1136/gut.40.3.356
  contributor:
    fullname: Hammel
– volume: 19
  start-page: 5
  year: 2011
  ident: R58-1-20241021
  article-title: Titration of serum CEA, p53 antibodies and CEA-IgM complexes in 142 patients with colorectal cancer and 150 healthy blood donors
  publication-title: Ann Cancer Res
  contributor:
    fullname: Kojima
– volume: 178
  start-page: 1009
  year: 2011
  ident: R44-1-20241021
  article-title: Sperm-associated antigen 9 is a novel biomarker for colorectal cancer and is involved in tumor growth and tumorigenicity
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2010.11.047
  contributor:
    fullname: Kanojia
– volume: 23
  start-page: 2415
  year: 2012
  ident: R31-1-20241021
  article-title: Elevated serum antibodies against insulin-like growth factor-binding protein-2 allow detecting early-stage cancers: Evidences from glioma and colorectal carcinoma studies
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mds007
  contributor:
    fullname: Li
– volume: 12
  start-page: 520
  year: 2012
  ident: R48-1-20241021
  article-title: Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-12-520
  contributor:
    fullname: Hanafusa
– volume: 1
  start-page: 336
  year: 2007
  ident: R29-1-20241021
  article-title: Proteomics-based identification of HSP60 as a tumor-associated antigen in colorectal cancer
  publication-title: Proteomics Clin Appl
  doi: 10.1002/prca.200600718
  contributor:
    fullname: He
– volume: 18
  start-page: 543
  year: 1999
  ident: R49-1-20241021
  article-title: Prognostic significance of autoantibodies against tropomyosin in patients with colorectal adenocarcinoma
  publication-title: Hybridoma
  contributor:
    fullname: Syrigos
– volume: 66
  start-page: 7
  year: 2016
  ident: R1-1-20241021
  article-title: Cancer statistics, 2016
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21332
  contributor:
    fullname: Siegel
– volume: 19
  start-page: 114
  year: 2004
  ident: R70-1-20241021
  article-title: Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy
  publication-title: Int J Colorectal Dis
  doi: 10.1007/s00384-003-0553-5
  contributor:
    fullname: Lechpammer
– volume: 108
  start-page: 107
  year: 2013
  ident: R74-1-20241021
  article-title: Early detection of cancer in the general population: A blinded case-control study of p53 autoantibodies in colorectal cancer
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2012.517
  contributor:
    fullname: Pedersen
– volume: 17
  start-page: 5715
  year: 2011
  ident: R57-1-20241021
  article-title: Development of autoantibody signatures as biomarkers for early detection of colorectal carcinoma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-0199
  contributor:
    fullname: Chang
– volume: 12
  start-page: 785
  year: 1998
  ident: R63-1-20241021
  article-title: P53 genetic alterations, protein expression and autoantibodies in human colorectal carcinoma: A comparative study
  publication-title: Int J Oncol
  contributor:
    fullname: Hallak
– volume: 46
  start-page: 35
  year: 1990
  ident: R16-1-20241021
  article-title: Circulating antibodies against c-myc oncogene product in sera of colorectal cancer patients
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910460109
  contributor:
    fullname: Ben-Mahrez
– volume: 128
  start-page: 1860
  year: 2011
  ident: R37-1-20241021
  article-title: Seromic profiling of colorectal cancer patients with novel glycopeptide microarray
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25778
  contributor:
    fullname: Pedersen
– volume: 11
  start-page: e0156971
  year: 2016
  ident: R7-1-20241021
  article-title: Human blood autoantibodies in the detection of colorectal cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0156971
  contributor:
    fullname: Negm
– volume: 10
  start-page: M110
  year: 2011
  ident: R24-1-20241021
  article-title: Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M110.001784
  contributor:
    fullname: Babel
SSID ssj0057228
Score 2.3280737
SecondaryResourceType review_article
Snippet Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. Early diagnosis improves prognosis and long-term outcomes. Several studies have...
SourceID proquest
gale
crossref
pubmed
wolterskluwer
SourceType Aggregation Database
Index Database
Publisher
StartPage 819
SubjectTerms Animals
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Biological markers
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - immunology
Diagnosis
Health aspects
Humans
Prognosis
Risk factors
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3ri9QwEB_0BBFE9HxVT4kgqx8uXvNqG7_IcngcB6eH7MF-C02Tyiq2524Xuf_eTJt9iQr90JLpI52ZTB6__AbgdZ3JOvOCUWWVptJxS21aSFrxEJu9YiLv5zvOP2Wnl_JsqqZxwm0RYZWrNrFvqF1b4Rz5UTAtmXMhefrh6ifFrFG4uhpTaNyEW4ynGUK68ul6wKVy3udWRUYainyXA7WPZKk4-lbNu3dnx18mJpMGaXa2otKfbfNWcLr7q8VF7MX3HsO-FYlO7sO92IUk40HnD-CGb_bh9nlcJN-H0cVAR319SCab3VWLQzIiFxui6uuH8Hm87NrwZ2e2RSwhmTUkdAeJG9B3s3AHorfiadm4cIkvQVWStib4GGwvw7dUaDvzR3B58nFyfEpjggVaKa5nNLeeFyFK6lSWos51WZReBx_P6tQVzrJSCc85yzLLLCYlRrpAVnnphNM187V4DHtN2_inQBjiKFzqC19qqYq8KIMMcy6MwJzONUvg7eoHm6uBR8OE8QfqwqAuzEYXCbxBBRj0sG5eVmXcKBBehFxVZoxjHCTi4wmMdiS_DkzdfxM82BEMLlTtFq90baILL8zG4BJ4tS7GOxGW1vh22csIiRE9T-DJYCPr2gmpeBGOBN7vGI35Mexz_Ff1TeijmZX-n_3_y57DHY4Ymx4-fAB73XzpX4ROUmdf9p7wG-JrECk
  priority: 102
  providerName: ProQuest
Title Autoantibodies in the diagnosis, prognosis, and prediction of colorectal cancer
URI http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2021;volume=17;issue=4;spage=819;epage=833;aulast=Niloofa;type=0
https://www.ncbi.nlm.nih.gov/pubmed/34528528
https://www.proquest.com/docview/2574723420
https://search.proquest.com/docview/2573442997
Volume 17
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9NAFB7WXRBBRNdbdC0RpPqw0cwlmcTgQ126LAtby9LFvg1JZiLxkkibIv33npNJehF9EvrQkjOdnDn35Mw3hLwqQlGEhlMvyILYE5plXuZHwssZxGYTUC7b5x1Xk_DiRlzOg_kB6buWsKsyR3YX3VK2BXq3iO3Wru7hleQeIlgma9AHKIsZTXprlom9Y5FYk4SQl3SenfMkXUFS2nyYlN_rukiTFpkIKv4jLM7w5IfPfNw78kCy9mjWzWQWGUhQn7_7mi-at5dn1zMVCoUoPTtB7U_XvhPb7v6q8R348lvbAr8TyM7vk3tdBuqOLLcPyIGpjsntq-4d-zEZTi2a9frUnW03Zy1P3aE73eJcrx-ST6NVU4NgyqzGVkS3rFzIJl1tm_dKGIHNX93XtNLwEydBTXDrwsW_QXcL92Jl8YjcnI9nZxdedz6DlwcsLj2ZGRZBkI19kfJCxmmUmhhcRFj4OtIZTQNuGKNhmNEMzzRGtEGaG6G5jgtqCv6YHFZ1ZZ4Sl2IbhvZNZNJYBJGMUqChWkMBp2MZU4e86RdY_bQwHArKF5SFQlmorSwc8hoFoNBAm0Wap90-A5gIoa7UCEskxPFjDhnuUX6xQN9_IzzZIwQLzPcv97JWndouFbhCIRlw7Dvk5eYyjsSutsrUq5aGC0wIpEOeWB3ZcMdFwCL4OOT9ntKoH3ab5L_YV6Dvqpf_s_8Z_JzcQcOyvckn5LBZrMwLyMCabEBuybkckKOP48n0etBazW_lszL-
link.rule.ids 315,783,787,12068,21400,27470,27936,27937,31731,31732,33756,33757,43322,43817
linkProvider Wolters Kluwer Health
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba9RAFD5oCyqIaLUarTqCrD50bOaSW19kLS1r7a5L2ULfhiQzkbU0qbtZpP--c5JJd1dUyENCTq7nNpdvvgPwvghlERrBaJAFCZWaZzTzY0lzbnOzCZiImvGO4SgcnMnj8-DcDbjNHayyi4lNoNZVjmPke9a0ZMSF5P7nq18Uq0bh7KoroXEXNpGqyna-Nr8cjsanXSwOIt5UV0VOGoqMly25j2S-2PuZz-pPxwenExVKhUQ7K3npz-i8kp4e_q5wGnt-0aDYV3LR0WN45BqRpN9q_QncMeUW3Bu6afIt6I1bQurrXTJZrq-a75IeGS-pqq-fwvf-oq7sv51mFaIJybQktkFIdIu_m9orEL_ldtNS20N8CCqTVAXB22DEtO-So_XMnsHZ0eHkYEBdiQWaBzyZ0igzPLZ5MvFlKoooSePUJNbLw8LXsc5YGgjDOQvDjGVYlhgJA1lupBY6KZgpxDZslFVpXgBhiKTQvolNmsggjuLUyjCtbR9MJ1HCPPjY_WB11TJpKNsDQV0o1IVa6sKDD6gAhT5Wz9I8dUsF7IOQrUr1sZeDVHzcg96a5I-Wq_tvgjtrgtaJ8vXTna6Vc-K5WpqcB-9uT-OVCEwrTbVoZITEnB558Ly1kduvEzLgsd082F8zGnXZrnT81-cr20pTnf5f_v_N3sL9wWR4ok6-jr69ggccETcNmHgHNurZwry2TaY6e-P84gZ0ExR_
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Autoantibodies+in+the+diagnosis%2C+prognosis%2C+and+prediction+of+colorectal+cancer&rft.jtitle=Journal+of+cancer+research+and+therapeutics&rft.au=Niloofa%2C+Roshan&rft.au=De+Zoysa%2C+M&rft.au=Seneviratne%2C+L&rft.date=2021-07-01&rft.pub=Medknow+Publications+and+Media+Pvt.+Ltd&rft.issn=0973-1482&rft.eissn=1998-4138&rft.volume=17&rft.issue=4&rft.spage=819&rft_id=info:doi/10.4103%2Fjcrt.JCRT_64_19&rft.externalDocID=A675881862
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0973-1482&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0973-1482&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0973-1482&client=summon