Burn injury dampens erythroid cell production through reprioritizing bone marrow hematopoietic response

• Published in: The journal of trauma Vol. 71; no. 5; p. 1288
• Main Authors: Posluszny, Jr, Joseph A, Muthumalaiappan, Kuzhali, Kini, Ameet R, Szilagyi, Andrea, He, Li-Ke, Li, Yanxia, Gamelli, Richard L, Shankar, Ravi
• Format: Journal Article
• Language: English
• Published: United States 01.11.2011
• Subjects: Analysis of Variance; Anemia - etiology; Anemia - metabolism; Animals; Bone Marrow Cells - metabolism; Burns - complications; Erythroid Cells - metabolism; Flow Cytometry; Hematopoietic System - metabolism; Lymphocytes - metabolism; Male; Mice; Myeloid Cells - metabolism; Random Allocation; Reticulocytes - metabolism

Anemia in burn patients is due to surgical blood loss and anemia of critical illness. Because the commitment paradigm of common bone marrow progenitors dictates the production of erythroid, myeloid, and lymphoid cells, we hypothesized that skewed bone marrow lineage commitment decreases red cell pro...