TRPC3 Regulates Islet Beta‐Cell Insulin Secretion

• Published in: Advanced science Vol. 10; no. 6; pp. e2204846 - n/a
• Main Authors: Rached, Gaëlle, Saliba, Youakim, Maddah, Dina, Hajal, Joelle, Smayra, Viviane, Bakhos, Jules‐Joel, Groschner, Klaus, Birnbaumer, Lutz, Fares, Nassim
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.02.2023; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Antibodies; beta cells; calcium; Calcium - metabolism; diabetes; Diabetes Mellitus, Experimental - metabolism; Glucose; Glucose - metabolism; Humans; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells; Mice; Molecular weight; Physiology; Plasma; TRPC3; calcium; TRPC3; insulin; diabetes; beta cells

Insulin release is tightly controlled by glucose‐stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non‐selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose‐stimulated insulin secr...