Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA

• Published in: Journal of neurochemistry Vol. 107; no. 3; pp. 844 - 854
• Main Authors: Vihavainen, Tanja, Relander, Toni R.A, Leiviskä, Riikka, Airavaara, Mikko, Tuominen, Raimo K, Ahtee, Liisa, Piepponen, Timo Petteri
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.11.2008; Blackwell Publishing Ltd; Blackwell
• Subjects: 3,4-dyhydroxylphenylalanine; 3-hydroxybenzylhydrazine dihydrochloride; Animals; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biochemistry; Biological and medical sciences; Brain - drug effects; Brain - metabolism; caudate putamen; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; chronic oral nicotine treatment; Dihydroxyphenylalanine - metabolism; dopamine; Dopamine - metabolism; Extracellular Fluid - metabolism; Fundamental and applied biological sciences. Psychology; GABA; gamma-Aminobutyric Acid - drug effects; gamma-Aminobutyric Acid - metabolism; Homovanillic Acid - metabolism; Hydroxyindoleacetic Acid - metabolism; Male; Medical sciences; Mice; Microdialysis; morphine; Morphine - pharmacology; Motor Activity - drug effects; Narcotics; Narcotics - pharmacology; Neurology; Neuropharmacology; Neurotransmitter Agents - metabolism; Neurotransmitters; Nicotine; Nicotine - pharmacology; Nicotinic Agonists - pharmacology; nipecotic acid; nucleus accumbens; Pharmacology. Drug treatments; Rodents; substantia nigra; Time; ventral tegmental area; Vertebrates: nervous system and sense organs; α-methyltyrosine; 3,4-dyhydroxylphenylalanine; 3-hydroxybenzyl- hydrazine dihydrochloride; Central nervous system; Morphine; nipecotic acid; Encephalon; Caudate nucleus; Ventral tegmental area; α-methyltyrosine; Release; substantia nigra; Dopamine; Interaction; caudate putamen; Rodentia; chronic oral nicotine treatment; Basal ganglion; Corpus striatum; nucleus accumbens; Catecholamine; Extracellular; Vertebrata; Chronic; Mammalia; Treatment; Mouse; microdialysis; Neurotransmitter; GABA; Nicotine

Previously, we have shown that 7-week oral nicotine treatment enhances morphine-induced behaviors and dopaminergic activity in the mouse brain. In this study, we further characterized the nicotine-morphine interaction in the mesolimbic and nigrostriatal dopaminergic systems, as well as in the GABAer...