Afferent discharges from coronary arterial and ventricular receptors in anaesthetized dogs

1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from stimulation of receptors in the coronary arteries, although contribution from left ventricular receptors was not excluded. This investigation was un...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of physiology Vol. 472; no. 1; pp. 785 - 799
Main Authors Drinkhill, M J, Moore, J, Hainsworth, R
Format Journal Article
LanguageEnglish
Published Oxford The Physiological Society 01.12.1993
Blackwell
Subjects
Online AccessGet full text

Cover

Loading…
Abstract 1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from stimulation of receptors in the coronary arteries, although contribution from left ventricular receptors was not excluded. This investigation was undertaken to resolve this question and to determine the afferent nerve fibres likely to be involved in this reflex. 2. In chloralose-anaesthetized dogs a perfusion circuit was used which allowed us to change the pressures in: (a) the aortic root, coronary arteries and the left ventricle; (b) aortic root and coronary arteries at constant ventricular pressure; and (c) the left ventricle with mean (although not pulse) aortic pressure constant. Electrophysiological recordings were made from slips dissected from the vagus nerve which responded with an increase in discharge to either combined increases in the pressures, or to aortic root injections of veratridine. 3. Recordings were made from twenty-one vagal afferents. On the basis of their conduction velocities, eleven were classified as non-myelinated and ten as myelinated. 4. Three non-myelinated afferents responded to veratridine injections only, three to both veratridine and combined aortic root and ventricular pressure changes, and five to pressure changes only. Responses to pressure occurred only when ventricular systolic pressure exceeded 30 kPa. 5. None of the myelinated afferents responded to veratridine. All showed increases in discharge to combined increases in mean aortic root, coronary arterial and left ventricular systolic pressures, which would be graded over a range similar to that which caused reflex changes. All were more sensitive to changes in mean coronary pressure than to changes in ventricular systolic pressure. 6. We conclude that myelinated vagal afferent nerve fibres, which respond predominantly to changes in mean coronary arterial pressure, are likely to be responsible for the vasodilation to the changes in mean aortic root pressure previously reported. These fibres are probably attached to coronary arterial mechanoreceptors.
AbstractList 1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from stimulation of receptors in the coronary arteries, although contribution from left ventricular receptors was not excluded. This investigation was undertaken to resolve this question and to determine the afferent nerve fibres likely to be involved in this reflex. 2. In chloralose-anaesthetized dogs a perfusion circuit was used which allowed us to change the pressures in: (a) the aortic root, coronary arteries and the left ventricle; (b) aortic root and coronary arteries at constant ventricular pressure; and (c) the left ventricle with mean (although not pulse) aortic pressure constant. Electrophysiological recordings were made from slips dissected from the vagus nerve which responded with an increase in discharge to either combined increases in the pressures, or to aortic root injections of veratridine. 3. Recordings were made from twenty-one vagal afferents. On the basis of their conduction velocities, eleven were classified as non-myelinated and ten as myelinated. 4. Three non-myelinated afferents responded to veratridine injections only, three to both veratridine and combined aortic root and ventricular pressure changes, and five to pressure changes only. Responses to pressure occurred only when ventricular systolic pressure exceeded 30 kPa. 5. None of the myelinated afferents responded to veratridine. All showed increases in discharge to combined increases in mean aortic root, coronary arterial and left ventricular systolic pressures, which would be graded over a range similar to that which caused reflex changes. All were more sensitive to changes in mean coronary pressure than to changes in ventricular systolic pressure. 6. We conclude that myelinated vagal afferent nerve fibres, which respond predominantly to changes in mean coronary arterial pressure, are likely to be responsible for the vasodilation to the changes in mean aortic root pressure previously reported. These fibres are probably attached to coronary arterial mechanoreceptors.
1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from stimulation of receptors in the coronary arteries, although contribution from left ventricular receptors was not excluded. This investigation was undertaken to resolve this question and to determine the afferent nerve fibres likely to be involved in this reflex. 2. In chloralose-anaesthetized dogs a perfusion circuit was used which allowed us to change the pressures in: (a) the aortic root, coronary arteries and the left ventricle; (b) aortic root and coronary arteries at constant ventricular pressure; and (c) the left ventricle with mean (although not pulse) aortic pressure constant. Electrophysiological recordings were made from slips dissected from the vagus nerve which responded with an increase in discharge to either combined increases in the pressures, or to aortic root injections of veratridine. 3. Recordings were made from twenty-one vagal afferents. On the basis of their conduction velocities, eleven were classified as non-myelinated and ten as myelinated. 4. Three non-myelinated afferents responded to veratridine injections only, three to both veratridine and combined aortic root and ventricular pressure changes, and five to pressure changes only. Responses to pressure occurred only when ventricular systolic pressure exceeded 30 kPa. 5. None of the myelinated afferents responded to veratridine. All showed increases in discharge to combined increases in mean aortic root, coronary arterial and left ventricular systolic pressures, which would be graded over a range similar to that which caused reflex changes. All were more sensitive to changes in mean coronary pressure than to changes in ventricular systolic pressure. 6. We conclude that myelinated vagal afferent nerve fibres, which respond predominantly to changes in mean coronary arterial pressure, are likely to be responsible for the vasodilation to the changes in mean aortic root pressure previously reported. These fibres are probably attached to coronary arterial mechanoreceptors.
Author R Hainsworth
M J Drinkhill
J Moore
AuthorAffiliation Academic Unit of Cardiovascular Studies, University of Leeds
AuthorAffiliation_xml – name: Academic Unit of Cardiovascular Studies, University of Leeds
Author_xml – sequence: 1
  givenname: M J
  surname: Drinkhill
  fullname: Drinkhill, M J
– sequence: 2
  givenname: J
  surname: Moore
  fullname: Moore, J
– sequence: 3
  givenname: R
  surname: Hainsworth
  fullname: Hainsworth, R
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3826828$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/8145172$$D View this record in MEDLINE/PubMed
BookMark eNqNkU1v1DAQhi1UVLaFnwDKAcEpiz-SOL4gtRXlQ5XgUC5cLMceb1x542BnWy2_vo6yXcGN00ieZ955x-8ZOhnCAAi9IXhNCGEf7sZ-n1zwayIEW6cR58rZM7QiVSNKzgU7QSuMKS0Zr8kLdJbSHcaEYSFO0WlLqppwukK_LqyFCMNUGJd0r-IGUmFj2BY6xDCouC9UnCA65Qs1mOI-o9HpnVexiKBhnEJMhRtyU0GaepjcHzCFCZv0Ej23yid4dajn6Of1p9urL-XN989fry5uSl1TUZe6bbkWjHem6YQwrcGCaVNxTbuGKiuoAWw6XNlsHgjQprNMdZowa4jtjGHn6OOiO-66LRg9O1RejtFts30ZlJP_dgbXy024l4Q0uCYsC7w7CMTwe5evkNv8F-C9GiDskuQN5TXndQabBdQxpBTBHpcQLOdU5FMqck5FPqWSB1__bfE4dogh998e-ipp5W1Ug3bpiLGWNi1tM3a5YA_Ow_4_l8vbbz_mh4pTwtv5iPeLSO82_YOLIJexFLSDaS8zJ4mcyUfuZsFm
CODEN JPHYA7
CitedBy_id crossref_primary_10_1016_j_autneu_2024_103180
crossref_primary_10_1111_pace_13547
crossref_primary_10_1111_j_1469_7793_1998_237br_x
crossref_primary_10_2459_JCM_0000000000000406
crossref_primary_10_1046_j_1440_1681_2001_03522_x
crossref_primary_10_1113_JP282305
crossref_primary_10_1152_japplphysiol_00307_2020
crossref_primary_10_1152_jn_1998_79_5_2374
crossref_primary_10_1111_j_1469_7793_2000_00349_x
crossref_primary_10_1113_expphysiol_2013_072637
crossref_primary_10_1152_ajpheart_00131_2004
crossref_primary_10_1152_japplphysiol_00804_2005
crossref_primary_10_1111_j_1469_7793_2001_0549f_x
crossref_primary_10_1051_ject_200537306
crossref_primary_10_1152_ajpheart_1998_275_4_H1169
crossref_primary_10_1111_j_1469_7793_1998_543bb_x
ContentType Journal Article
Copyright 1993 The Physiological Society
1994 INIST-CNRS
Copyright_xml – notice: 1993 The Physiological Society
– notice: 1994 INIST-CNRS
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1113/jphysiol.1993.sp019973
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef
MEDLINE



Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1469-7793
EndPage 799
ExternalDocumentID 10_1113_jphysiol_1993_sp019973
8145172
3826828
TJP19934721785
472_1_785
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID -
08R
0YM
1OB
1OC
24P
29L
2WC
33P
3O-
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52T
52U
52V
52W
52X
53G
55
5GY
5HH
5LA
5RE
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
AAESR
AAYJJ
ABFLS
ABITZ
ABIVO
ABOCM
ABPPZ
ABPTK
ABUFD
ACGFS
ACIWK
ACNCT
ACPRK
ADACO
ADBBV
ADZMN
AEUQT
AFBPY
AFFNX
ALAGY
ALMA_UNASSIGNED_HOLDINGS
AMBMR
ATUGU
BAFTC
BAWUL
BY8
CS3
D-6
D-7
D-E
D-F
DCZOG
DIK
DR2
DRMAN
DZ
E3Z
EBS
EJD
F00
F01
F04
F20
F5P
FA8
FIJ
GA
GJ
GX1
H.X
H13
H~9
IX1
J0M
LATKE
LC2
LC3
LI0
LW6
LYRES
MK4
MRFUL
MVM
N04
N05
N9A
NEJ
NF
O0-
O66
OHM
OHT
OK1
P2P
P2W
P2X
P2Z
P4A
Q.N
RIG
RPM
RX1
SUPJJ
TLM
TN5
UPT
UQL
V8K
VH1
W8V
W99
WBKPD
WH7
WIH
WIJ
WIN
WNSPC
WOQ
WRC
WT
WXI
X
X7M
YZZ
ZA5
ZGI
ZXP
ZY4
---
-DZ
-~X
.55
.GJ
18M
36B
AAFWJ
ABCQN
ABEML
ABJNI
ACGFO
ACPOU
ACSCC
ADKYN
ADOZA
AEGXH
AFEBI
AI.
AIAGR
AOIJS
IPNFZ
K48
LEEKS
NF~
OIG
SAMSI
TR2
W8F
WXSBR
XOL
YQT
~WT
.3N
.GA
.Y3
05W
0R~
10A
123
31~
3EH
52S
930
A01
A03
AAEVG
AAHHS
AAJUZ
AANLZ
AAONW
AASGY
AAUGY
AAVGM
AAXRX
AAZKR
ABCUV
ABCVL
ABHUG
ABPVW
ABWRO
ABXGK
ACAHQ
ACCFJ
ACCZN
ACFBH
ACGOF
ACMXC
ACXBN
ACXME
ACXQS
ADAWD
ADBTR
ADDAD
ADEOM
ADIZJ
ADMGS
ADXAS
AEEZP
AEIGN
AEIMD
AEQDE
AEUYR
AFGKR
AFMIJ
AFPWT
AFVGU
AFZJQ
AGJLS
AIACR
AIURR
AIWBW
AJBDE
ALUQN
AMYDB
AZBYB
AZVAB
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
C1A
C45
CAG
CHEAL
COF
DPXWK
DRFUL
DRSTM
EMOBN
EX3
FUBAC
G-S
G.N
GODZA
HF~
HZI
HZ~
IHE
IQODW
KBYEO
LH4
LITHE
LOXES
LP6
LP7
LUTES
MEWTI
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
O9-
OVD
P4B
P4D
Q11
QB0
R.K
ROL
TEORI
UB1
UKR
WHG
WIK
WOHZO
WOW
WQJ
WYISQ
XG1
YBU
YHG
YKV
YSK
YXB
YYP
ZZTAW
~IA
ABQWH
AFFPM
AHBTC
AITYG
CGR
CUY
CVF
ECM
EIF
HGLYW
NPM
AAMNL
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-c5295-c887c937bd6b99d8d093cd47c2b62af92de0db04f013e1e26bf3abc13fd1fbdd3
IEDL.DBID RPM
ISSN 0022-3751
IngestDate Tue Nov 05 04:35:30 EST 2024
Wed Dec 04 00:55:12 EST 2024
Fri Dec 06 01:33:24 EST 2024
Sat Sep 28 08:32:43 EDT 2024
Sun Oct 29 17:07:07 EDT 2023
Sat Aug 24 00:48:43 EDT 2024
Fri Jan 15 02:13:22 EST 2021
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Heart
Fissipedia
Systolic pressure
Carnivora
Mechanoreceptor
Coronary artery
Discharge pattern
Myelinated nerve fiber
Vasodilation
Left ventricle
Vasomotricity
Vertebrata
Mammalia
Blood vessel
Aorta
Blood pressure
Circulatory system
Hemodynamics
Vagus nerve
Dog
Language English
License CC BY 4.0
http://onlinelibrary.wiley.com/termsAndConditions#vor
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5295-c887c937bd6b99d8d093cd47c2b62af92de0db04f013e1e26bf3abc13fd1fbdd3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://doi.org/10.1113/jphysiol.1993.sp019973
PMID 8145172
PQID 76275775
PQPubID 23479
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_1160513
proquest_miscellaneous_76275775
crossref_primary_10_1113_jphysiol_1993_sp019973
pubmed_primary_8145172
pascalfrancis_primary_3826828
wiley_primary_10_1113_jphysiol_1993_sp019973_TJP19934721785
highwire_physiosociety_472_1_785
PublicationCentury 1900
PublicationDate December 1, 1993
PublicationDateYYYYMMDD 1993-12-01
PublicationDate_xml – month: 12
  year: 1993
  text: December 1, 1993
  day: 01
PublicationDecade 1990
PublicationPlace Oxford
PublicationPlace_xml – name: Oxford
– name: England
PublicationTitle The Journal of physiology
PublicationTitleAlternate J Physiol
PublicationYear 1993
Publisher The Physiological Society
Blackwell
Publisher_xml – name: The Physiological Society
– name: Blackwell
SSID ssj0013099
Score 1.5831562
Snippet 1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from...
1. Previous work has shown that increases in aortic root pressure result in reflex vasodilation, and that this response is likely to result mainly from...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
wiley
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 785
SubjectTerms Afferent Pathways - drug effects
Afferent Pathways - physiology
Anesthesia
Animals
Biological and medical sciences
Blood Pressure - physiology
Coronary Vessels - drug effects
Coronary Vessels - innervation
Coronary Vessels - physiology
Dogs
Electrophysiology
Female
Fundamental and applied biological sciences. Psychology
Heart
Heart - drug effects
Heart - innervation
Heart - physiology
Heart Ventricles - drug effects
Heart Ventricles - innervation
Male
Reflex - drug effects
Reflex - physiology
Vagus Nerve - drug effects
Vagus Nerve - physiology
Ventricular Function
Ventricular Function, Left - drug effects
Ventricular Function, Left - physiology
Veratridine - pharmacology
Vertebrates: cardiovascular system
Title Afferent discharges from coronary arterial and ventricular receptors in anaesthetized dogs
URI http://jp.physoc.org/content/472/1/785.abstract
https://onlinelibrary.wiley.com/doi/abs/10.1113%2Fjphysiol.1993.sp019973
https://www.ncbi.nlm.nih.gov/pubmed/8145172
https://search.proquest.com/docview/76275775
https://pubmed.ncbi.nlm.nih.gov/PMC1160513
Volume 472
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6SQCGX0jYNdZu0OpTenLUs27LpaQkNIZCyhwRCL0IvJ1uy9rLeHLa_PjOyvXRpD6VX62FJM5JmRt_MAHyupK-yMrVxlWlHKcx8bHLr4xyFCZ_WuhSeTAPX34vL2-zqLr_bg3z0hQmgfWvmZ83j4qyZPwRs5XJhJyNObDK7PucchXAuJvuwj9fvqKKPTwdJVW1DhMucD27BHOv_DNaC9pFc9ATu2IRQFuIQXpSUr1amu3fTGC-Y4JK6wxWr-1QXf5NF_4RU_i7qhrvq4hW8HIRMNu0n8xr2fPMGjqYNKtiLDfvCZv0A2_vNEfyY9hlS1owcdCluku8YOZ0wS8EN9GrDAuwT-ZTpxjHCRwajoV4xPC39ktL1sHmDhRrH-uDX81_eMdfed2_h9uLbzfllPCRciC2998UWTxyL8opxhakqV7qkEtZl0qamSHVdpc4nziRZTbZT7tPC1EIby0XteG2cE8dw0LSNfwfMZcIZk-kcr0hUIbGDHJsZKR21K8oIJuNSq2UfV0P1-ohQI5kUkUmNZIqAjRRRfYWux7WqTKaKK1nmEZzuUGrbs0AlClXLCD6NlFO4i-hpRDe-feqUpGDNUmIPxz0dt00H1ohA7hB4W07huXdLkGtDmO6BSyP4GljhH6epbq5m9AEnxXFK7__7vx_gMIAzA_TmBA7Wqyd_igLU2nwMG-YZYEkdZw
link.rule.ids 230,314,727,780,784,885,27924,27925,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NIcReEDAmAoz5AfGWNY6TOBZP1cRUxjr1oZMmXix_Zeu0JlXbPZS_nrOTVFTwgHiNc07Od7bv7N_dAXwS3ImsTE0sMmV9CTMX69y4OEdjwqWVKpnzRwPjq2J0nV3c5Dd7kPexMAG0b_TstH6Yn9azu4CtXMzNoMeJDSbjM0rRCKds8ASe5owL2jvp_eVBIsQ2STjPaRcYTJHiPpwXNA8-SI_hnE08zoIdwLPSV6zl6e7u1GcM9oBJtcIxq9piF3-zRv8EVf5u7Ibd6vwlvOjMTDJs2XkFe65-DYfDGl3s-YZ8JpP2B5vbzSH8GLY1UtbEh-j6zEluRXzYCTE-vYFabkgAfqKmElVb4hGS4dhQLQmul27hC_aQWY2NCv_1zq1nP50ltrldvYHr86_Ts1HclVyIjb_xiw2uOQYtFm0LLYQtbSKYsRk3qS5SVYnUusTqJKv86Sl1aaErprShrLK00tayI9ivm9q9BWIzZrXOVI6bJDqR2EGOZJpz6-mKMoJBP9Ry0WbWkK1HwmQvJunFJHsxRUB6icj2hVWLbJUZTyWVvMwjON6R1LZnhm4UOpcRnPSSkziP_OWIql3zuJLcp2vmHHs4auW4Je1UIwK-I-Btu0_QvduCehsSdXd6GsGXoAr_yKacXkz8A2SKIkvv_vu7J_B8NB1fystvV9_fw0GAagYgzgfYXy8f3TGaU2v9MUyeX30cILw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BEagXBJSqAUp9QNzSbOIkTsRpVViVQqs9tFLFxfIr7aJustpsD8uvZ8ZJVl3BAXGNM07GM7Zn7G9mAD6UwpVpkZiwTJWlEmYu1JlxYYbGhEsqVXBHRwPnF_npVXp2nV0_KPXlQftGz47ru_lxPbv12MrF3EQDTiyanp_EMRrhMY8Wtooew5OMo5INjvpwgTAqy02icJHFfXBwjFQ__ZlBc0eBehzn7YiwFnwXnhZUtVYk2zvUkDWYQJOqxXGruoIXf7NI_wRWPjR4_Y41eQHPe1OTjTuWXsIjV7-CvXGNbvZ8zT6yafeDzc16D36MuzopK0ZhupQ9ybWMQk-YoRQHarlmHvyJ2spUbRmhJP3RoVoyXDPdgor2sFmNjQr_9datZr-cZba5aV_D1eTL5clp2JddCA3d-oUG1x2DVou2uS5LW9hRyY1NhUl0nqiqTKwbWT1KKzpBjV2S64orbWJe2bjS1vJ92Kmb2h0Asym3Wqcqw40SHUnsIEMyLYQlurwIIBqGWi667Bqy80q4HMQkSUxyEFMAbJCI7F5oO3SrTEUiYymKLIDDLUlteuboSqGDGcDRIDmJc4kuSFTtmvtWCkrZLAT2sN_JcUPaq0YAYkvAm3ZK0r3dgrrrk3X3uhrAJ68K_8imvDyb0gNkKkaW3vz3d4_g2fTzRH7_evHtLex6tKbH4ryDndXy3h2iRbXS7_3c-Q2N8CHP
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Afferent+discharges+from+coronary+arterial+and+ventricular+receptors+in+anaesthetized+dogs&rft.jtitle=The+Journal+of+physiology&rft.au=Drinkhill%2C+M+J&rft.au=Moore%2C+J&rft.au=Hainsworth%2C+R&rft.date=1993-12-01&rft.issn=0022-3751&rft.eissn=1469-7793&rft.volume=472&rft.issue=1&rft.spage=785&rft.epage=799&rft_id=info:doi/10.1113%2Fjphysiol.1993.sp019973&rft.externalDBID=10.1113%252Fjphysiol.1993.sp019973&rft.externalDocID=TJP19934721785
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3751&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3751&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3751&client=summon