The effects of atorvastatin on gluten‐induced intestinal T cell responses in coeliac disease

• Published in: Clinical and experimental immunology Vol. 142; no. 2; pp. 333 - 340
• Main Authors: Ráki, M., Molberg, Ø., Tollefsen, S., Lundin, K. E. A., Sollid, L. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2005; Blackwell; Oxford University Press; Blackwell Science Inc
• Subjects: Adult; Aged; Anticholesteremic Agents - pharmacology; Antigens, CD - metabolism; Apoptosis - drug effects; Atorvastatin; Biological and medical sciences; biopsy; CD83 Antigen; Celiac Disease - immunology; Cells, Cultured; Clinical Studies; coeliac disease; Cytokines - metabolism; dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dose-Response Relationship, Immunologic; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glutens - immunology; Heptanoic Acids - pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Immunity, Cellular - drug effects; Immunity, Mucosal - drug effects; Immunoglobulins - metabolism; Immunopathology; Intestinal Mucosa - immunology; Lymphocyte Activation - drug effects; Medical sciences; Membrane Glycoproteins - metabolism; Middle Aged; Organ Culture Techniques; Pyrroles - pharmacology; T cells; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Up-Regulation - drug effects; Immunopathology; Dendritic cell; Immune response; Digestive system; Enzyme; Enzyme inhibitor; Statin derivative; Coeliac disease; T cells; Immunology; dendritic cells; Intestinal malabsorption; Biopsy; Antigen presenting cell; T-Lymphocyte; Atorvastatin; Digestive diseases; Hydroxymethylglutaryl-CoA reductase; Intestinal disease; Oxidoreductases; Gluten

Summary Various experimental models suggest that the cholesterol‐lowering drugs statins may also modulate immune responses. Cellular level studies on human disorders are needed, however, to provide a rational basis for clinical testing of statins as immune therapy. Coeliac disease, a chronic small i...