Cadmium delays puberty onset and testis growth in adolescents
Summary Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. Design The aim of this cross‐sectional study was to evaluate pubertal onset and pituitary–gonadal axis horm...
Saved in:
| Published in | Clinical endocrinology (Oxford) Vol. 83; no. 3; pp. 357 - 362 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.09.2015
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Summary
Objective
Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels.
Design
The aim of this cross‐sectional study was to evaluate pubertal onset and pituitary–gonadal axis hormones in male adolescents with increased urinary levels of Cd.
Subjects
We studied 111 males, aged 12–14 years living in the Milazzo‐Valle del Mela area. A control age‐matched population (n = 60) living 28–45 km far from the industrial site was also enrolled.
Measurements
Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated.
Results
Cd levels were significantly higher in adolescents living in the Milazzo‐Valle del Mela area, compared to both age‐matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = −0·25; P = 0·0008), testosterone levels (Spearman's r = −0·0·37; two‐tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001).
Conclusions
This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. |
|---|---|
| AbstractList | Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels.OBJECTIVECadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels.The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents with increased urinary levels of Cd.DESIGNThe aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents with increased urinary levels of Cd.We studied 111 males, aged 12-14 years living in the Milazzo-Valle del Mela area. A control age-matched population (n = 60) living 28-45 km far from the industrial site was also enrolled.SUBJECTSWe studied 111 males, aged 12-14 years living in the Milazzo-Valle del Mela area. A control age-matched population (n = 60) living 28-45 km far from the industrial site was also enrolled.Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated.MEASUREMENTSPubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated.Cd levels were significantly higher in adolescents living in the Milazzo-Valle del Mela area, compared to both age-matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = -0·25; P = 0·0008), testosterone levels (Spearman's r = -0·0·37; two-tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001).RESULTSCd levels were significantly higher in adolescents living in the Milazzo-Valle del Mela area, compared to both age-matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = -0·25; P = 0·0008), testosterone levels (Spearman's r = -0·0·37; two-tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001).This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth.CONCLUSIONSThis study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents with increased urinary levels of Cd. We studied 111 males, aged 12-14 years living in the Milazzo-Valle del Mela area. A control age-matched population (n = 60) living 28-45 km far from the industrial site was also enrolled. Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated. Cd levels were significantly higher in adolescents living in the Milazzo-Valle del Mela area, compared to both age-matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = -0·25; P = 0·0008), testosterone levels (Spearman's r = -0·0·37; two-tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001). This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. Summary Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. Design The aim of this cross‐sectional study was to evaluate pubertal onset and pituitary–gonadal axis hormones in male adolescents with increased urinary levels of Cd. Subjects We studied 111 males, aged 12–14 years living in the Milazzo‐Valle del Mela area. A control age‐matched population (n = 60) living 28–45 km far from the industrial site was also enrolled. Measurements Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated. Results Cd levels were significantly higher in adolescents living in the Milazzo‐Valle del Mela area, compared to both age‐matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = −0·25; P = 0·0008), testosterone levels (Spearman's r = −0·0·37; two‐tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001). Conclusions This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. Design The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents with increased urinary levels of Cd. Subjects We studied 111 males, aged 12-14 years living in the Milazzo-Valle del Mela area. A control age-matched population (n = 60) living 28-45 km far from the industrial site was also enrolled. Measurements Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH, LH, testosterone and inhibin B were also investigated. Results Cd levels were significantly higher in adolescents living in the Milazzo-Valle del Mela area, compared to both age-matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = -0.25; P = 0.0008), testosterone levels (Spearman's r = -0.0.37; two-tailed P < 0.0001) and LH levels (Spearman's r = 0.048; P < 0.05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0.48; P < 0.0001). Conclusions This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. Summary Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. Design The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents with increased urinary levels of Cd. Subjects We studied 111 males, aged 12-14 years living in the Milazzo-Valle del Mela area. A control age-matched population (n = 60) living 28-45 km far from the industrial site was also enrolled. Measurements Pubertal stages were assessed by clinical examination according to Tanner's score. Mean testicular volume was also investigated by ultrasound examination. Urinary Cd concentration and blood levels of FSH,LH, testosterone and inhibin B were also investigated. Results Cd levels were significantly higher in adolescents living in the Milazzo-Valle del Mela area, compared to both age-matched subjects living far from the industrial plants and the reference values. Our population showed also a delayed onset of puberty, a smaller testicular volume and lower testosterone levels. An inverse correlation was found between urinary Cd and testicular volume (r = -0·25; P = 0·0008), testosterone levels (Spearman's r = -0·0·37; two-tailed P < 0·0001) and LH levels (Spearman's r = 0·048; P < 0·05). Testosterone levels were positively correlated with testicular volume (Spearman's r = 0·48; P < 0·0001). Conclusions This study, for the first time, suggests that increased Cd burden is associated with delayed onset of puberty in male adolescents and impaired testicular growth. |
| Author | Bitto, Alessandra Mecchio, Anna Pallio, Giovanni Luca, Filippo De Santamaria, Angelo Squadrito, Francesco Interdonato, Monica Irrera, Natasha Ramistella, Vincenzo Marini, Herbert Pizzino, Gabriele Altavilla, Domenica Minutoli, Letteria Galfo, Federica |
| Author_xml | – sequence: 1 givenname: Monica surname: Interdonato fullname: Interdonato, Monica organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 2 givenname: Gabriele surname: Pizzino fullname: Pizzino, Gabriele organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 3 givenname: Alessandra surname: Bitto fullname: Bitto, Alessandra organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 4 givenname: Federica surname: Galfo fullname: Galfo, Federica organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 5 givenname: Natasha surname: Irrera fullname: Irrera, Natasha organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 6 givenname: Anna surname: Mecchio fullname: Mecchio, Anna organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 7 givenname: Giovanni surname: Pallio fullname: Pallio, Giovanni organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 8 givenname: Vincenzo surname: Ramistella fullname: Ramistella, Vincenzo organization: Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy – sequence: 9 givenname: Filippo De surname: Luca fullname: Luca, Filippo De organization: Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy – sequence: 10 givenname: Angelo surname: Santamaria fullname: Santamaria, Angelo organization: Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy – sequence: 11 givenname: Letteria surname: Minutoli fullname: Minutoli, Letteria organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 12 givenname: Herbert surname: Marini fullname: Marini, Herbert organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 13 givenname: Francesco surname: Squadrito fullname: Squadrito, Francesco email: Correspondence: Francesco Squadrito, Department of Clinical and Experimental Medicine, Section of Pharmacology, Torre Biologica 5 floor, c/o AOU "G. Martino", Via C. Valeria, 98125 Messina, Italy. Tel.: +390902213648; Fax: +390902213300; , fsquadrito@unime.it organization: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy – sequence: 14 givenname: Domenica surname: Altavilla fullname: Altavilla, Domenica organization: Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25521350$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkT1PHDEQhi1EBAdJwR-IVkqTFAvj790iRXJ8JBEiFESUlm_tTUx27YvtFbl_jy8HFEiBaaZ53nfemdlD2z54i9ABhkNc6qiz_hATCWwLzTAVvCZE8G00AwpQgxBsF-2ldAMAvAG5g3YJ5wRTDjP0ca7N6KaxMnbQq1Qtp4WNeVUFn2yutDdVtim7VP2M4Tb_qpyvtAmDTWVmTq_Rq14Pyb657_vox-nJ1fxLff797Ov803ndcdKyumeSWkk7vmBWYqrL7LYzrBVtQ0pGbgjFtGcNNnrRN1RSA8J2642MoX1H6T56v_FdxvBnKoHU6EqCYdDehikp3HAOkq3dXkQlNFhAI9qCvnuC3oQp-rLImpKs5USQQr29p6bFaI1aRjfquFIPNyzAhw3QxZBStP0jgkGt_6PKrdS__xT26AnbuayzCz5H7YbnFLdusKv_W6v5ycWDot4oXMr276NCx99KSCq5ur44U_QYPsvjy2-K0jscRaxE |
| CitedBy_id | crossref_primary_10_1016_j_jhazmat_2019_121706 crossref_primary_10_1016_j_reprotox_2020_11_010 crossref_primary_10_1155_2017_8416763 crossref_primary_10_1016_j_ecoenv_2024_117623 crossref_primary_10_1002_tox_23482 crossref_primary_10_1155_2017_6341671 crossref_primary_10_1007_s12011_015_0526_x crossref_primary_10_3390_agronomy10060815 crossref_primary_10_1016_j_bbrc_2024_151265 crossref_primary_10_1016_j_envint_2024_108898 crossref_primary_10_3389_fpubh_2019_00061 crossref_primary_10_1007_s00210_019_01736_w crossref_primary_10_1016_j_chemosphere_2022_135786 crossref_primary_10_1136_bmjopen_2019_036160 crossref_primary_10_1016_j_envint_2018_02_020 crossref_primary_10_1007_s40618_022_01769_8 crossref_primary_10_1016_j_jinorgbio_2020_111279 crossref_primary_10_1155_2018_9162946 crossref_primary_10_1016_j_envint_2017_02_014 crossref_primary_10_1016_j_chemosphere_2019_05_016 crossref_primary_10_26559_mersinsbd_842650 crossref_primary_10_3390_nu14030663 crossref_primary_10_1016_j_envpol_2023_121434 crossref_primary_10_1016_j_tox_2023_153448 crossref_primary_10_3389_fphar_2016_00537 crossref_primary_10_1016_j_heliyon_2023_e22820 crossref_primary_10_1289_ehp_1509691 crossref_primary_10_3390_molecules28104024 crossref_primary_10_3390_ph14050386 crossref_primary_10_1016_j_sciaf_2020_e00578 crossref_primary_10_3389_fpubh_2020_00125 crossref_primary_10_1016_j_scitotenv_2020_137645 crossref_primary_10_17816_PED625943 |
| Cites_doi | 10.1016/j.fct.2013.06.024 10.1007/s10661-010-1339-1 10.1007/s00244-009-9417-5 10.1155/2014/326845 10.1136/adc.51.3.170 10.1016/j.chemosphere.2012.10.060 10.1210/jc.82.12.3976 10.1016/S0890-6238(99)00045-3 10.1016/j.redox.2014.05.003 10.1387/ijdb.130146ja 10.1016/j.jtemb.2010.01.002 10.1155/2013/898034 10.1016/S0378-4274(99)00159-9 10.1155/2013/394652 10.1016/j.ijheh.2012.01.003 10.1016/j.reprotox.2009.10.014 10.1210/er.2009-0002 10.1078/1438-4639-00179 10.1016/j.etap.2004.09.003 10.2131/jts.38.145 10.1016/j.toxlet.2003.10.004 10.1177/153537020122600615 10.1016/S0278-6915(00)00077-6 10.1258/000456306778520115 |
| ContentType | Journal Article |
| Copyright | 2014 John Wiley & Sons Ltd 2014 John Wiley & Sons Ltd. Copyright © 2015 John Wiley & Sons Ltd |
| Copyright_xml | – notice: 2014 John Wiley & Sons Ltd – notice: 2014 John Wiley & Sons Ltd. – notice: Copyright © 2015 John Wiley & Sons Ltd |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP K9. NAPCQ 7X8 7U7 C1K |
| DOI | 10.1111/cen.12704 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic Toxicology Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Calcium & Calcified Tissue Abstracts MEDLINE - Academic Toxicology Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1365-2265 |
| EndPage | 362 |
| ExternalDocumentID | 3788995171 25521350 10_1111_cen_12704 CEN12704 ark_67375_WNG_3D0B7DPJ_3 |
| Genre | article Research Support, Non-U.S. Gov't Multicenter Study Journal Article |
| GrantInformation_xml | – fundername: Sicilian Government funding |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 08P 0R~ 10A 1OB 1OC 29B 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AAQQT AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AHEFC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M J5H K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K REN RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YOC YUY ZGI ZXP ZZTAW ~IA ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACYXJ ADNMO AFWVQ ALVPJ AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION AAMMB AEFGJ AGXDD AIDQK AIDYY CGR CUY CVF ECM EIF NPM 7QP K9. NAPCQ 7X8 7U7 C1K |
| ID | FETCH-LOGICAL-c5294-f473e73c5b4e713a2139cd4969820305d2313f481dabf8373d06ec1270dd3fc33 |
| IEDL.DBID | DR2 |
| ISSN | 0300-0664 1365-2265 |
| IngestDate | Fri Jul 11 02:43:22 EDT 2025 Fri Jul 11 12:38:44 EDT 2025 Wed Aug 13 04:46:11 EDT 2025 Mon Jul 21 06:00:12 EDT 2025 Thu Apr 24 23:02:42 EDT 2025 Tue Jul 01 01:33:13 EDT 2025 Wed Jan 22 16:22:11 EST 2025 Wed Oct 30 09:54:05 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor 2014 John Wiley & Sons Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5294-f473e73c5b4e713a2139cd4969820305d2313f481dabf8373d06ec1270dd3fc33 |
| Notes | ark:/67375/WNG-3D0B7DPJ-3 istex:B311755C67F0A0388D94902631B2AF0B1BA3EE25 ArticleID:CEN12704 Sicilian Government funding These authors equally contributed. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen.12704 |
| PMID | 25521350 |
| PQID | 1707495262 |
| PQPubID | 36523 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_1855074820 proquest_miscellaneous_1708160869 proquest_journals_1707495262 pubmed_primary_25521350 crossref_primary_10_1111_cen_12704 crossref_citationtrail_10_1111_cen_12704 wiley_primary_10_1111_cen_12704_CEN12704 istex_primary_ark_67375_WNG_3D0B7DPJ_3 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | September 2015 |
| PublicationDateYYYYMMDD | 2015-09-01 |
| PublicationDate_xml | – month: 09 year: 2015 text: September 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford |
| PublicationTitle | Clinical endocrinology (Oxford) |
| PublicationTitleAlternate | Clin Endocrinol |
| PublicationYear | 2015 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc |
| References | Ademuyiwa, O., Agarwal, R., Chandra, R. et al. (2010) Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues. Journal of Trace Elements in Medicine and Biology, 24, 207-211. Kuczmarski, R.J., Ogden, C.L., Guo, S.S. et al. (2002) 2000 CDC growth charts for the United States: Methods and development. National Center for Health Statistics, Vital and Health Statistics Series. Interdonato, M., Bitto, A., Pizzino, G. et al. (2014) Levels of heavy metals in adolescents living in the industrialised area of milazzo-valle del mela (northern sicily). Journal of Environmental and Public Health, 2014, 326845. Diamanti-Kandarakis, E., Bourguignon, J.P., Giudice, L.C. et al. (2009) Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocrine Review, 30, 293-342. Luca, G., Lilli, C., Bellocci, C. et al. (2013) Toxicity of cadmium on Sertoli cell functional competence: an in vitro study. Journal of Biological Regulators & Homeostatic Agents, 27, 805-816. Andersson, A.M., Juul, A., Petersen, J.H. et al. (1997) Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. Journal of Clinical Endocrinology and Metabolism., 82, 3976-3981. Bernhoft, R.A. (2013) Cadmium toxicity and treatment. Scientific World Journal 2013, 394652. Review. Kakkar, P. & Jaffery, F.N. (2005) Biological markers for metal toxicity. Environmental Toxicology and Pharmacology, 19, 335-349. Schulz, C., Wilhelm, M., Heudorf, U. et al. (2012) Update of the reference and HBM values derived by the German Human Biomonitoring Commission. International Journal of Hygiene and Environmental Health, 215, 149. Lafuente, A., Márquez, N., Pérez-Lorenzo, M. et al. (2001) Cadmium effects on hypothalamic-pituitary-testicular axis in male rats. Experimental Biology and Medicine, 226, 605-611. Foote, R.H. (1999) Fertility of rabbit sperm exposed in vitro to cadmium and lead. Reproductive Toxicology, 13, 443-449. Mazej, Z., Al Sayegh-Petkovsek, S. & Pokorny, B. (2010) Heavy metal concentrations in food chain of Lake Velenjsko jezero, Slovenia: an artificial lake from mining. Archives of Environmental Contamination and Toxicology, 58, 998-1007. Ohtani, K., Yanagiba, Y., Ashimori, A. et al. (2013) Influence of injection timing on severity of cadmium-induced testicular toxicity in mice. Journal of Toxicological Sciences, 38, 145-150. Ji, Y.L., Wang, H., Liu, P. et al. (2010) Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reproductive Toxicology, 29, 176-183. Lafuente, A. & Esquifino, A.I. (1999) Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male. Toxicology Letters, 110, 209-218. Ho, C.K., Stoddart, M., Walton, M. et al. (2006) Calculated free testosterone in men: comparison of four equations and with free androgen index. Annals of clinical biochemistry, 43, 389-397. Au, W.W.. (2002) Susceptibility of children to environmental toxic substances. International Journal of Hygiene and Environmental Health 205, 501-503. Review. Pizzino, G., Bitto, A., Interdonato, M. et al. (2014) Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy). Redox Biology, 2, 686-693. Tanner, J.M. & Whitehouse, R.H. (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Archives of Disease in Childhood, 51, 170-179. Wang, B. & Du, Y. (2013) Cadmium and its neurotoxic effects. Oxidative Medicine and Cellular Longevity 2013, 898034. Review. Aitken, R.J. & Baker, M.A. (2013) Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development. International Journal of Developmental Biology, 57, 265-272. Lafuente, A., Márquez, N., Pérez-Lorenzo, M. et al. (2000) Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food and Chemical Toxicology, 38, 913-923. Qiao, M., Cai, C., Huang, Y. et al. (2011) Characterization of soil heavy metal contamination and potential health risk in metropolitan region of northern China. Environmental Monitoring and Assessment, 172, 353-365. Ciarrocca, M., Capozzella, A., Tomei, F. et al. (2013) Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone. Chemosphere, 90, 2077-2084. Liu, Q., Gu, J.H., Yuan, Y. et al. (2013) Effect of cadmium on rat Leydig cell testosterone production and DNA integrity in vitro. Biomedical and Environmental Sciences, 26, 769-773. Lafuente, A. (2013) The hypothalamic-pituitary-gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches. Food and Chemical Toxicology, 59, 395-404. Lafuente, A., González-Carracedo, A., Romero, A. et al. (2004) Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels. Toxicology Letters, 146, 175-182. 2013; 26 2010; 58 1997; 82 2013; 27 2004; 146 2010 2013; 90 2014; 2014 2002 2011; 172 2001; 226 1976; 51 2005; 19 2009; 30 2013; 59 2000; 38 2010; 24 2014; 2 2013; 38 2013; 2013 2013; 57 2010; 29 2006; 43 2002; 205 1999; 13 1999; 110 2012; 215 Liu Q. (e_1_2_6_21_1) 2013; 26 e_1_2_6_10_1 e_1_2_6_30_1 Luca G. (e_1_2_6_22_1) 2013; 27 e_1_2_6_19_1 Kuczmarski R.J. (e_1_2_6_14_1) 2002 e_1_2_6_13_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – reference: Qiao, M., Cai, C., Huang, Y. et al. (2011) Characterization of soil heavy metal contamination and potential health risk in metropolitan region of northern China. Environmental Monitoring and Assessment, 172, 353-365. – reference: Lafuente, A. (2013) The hypothalamic-pituitary-gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches. Food and Chemical Toxicology, 59, 395-404. – reference: Andersson, A.M., Juul, A., Petersen, J.H. et al. (1997) Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels. Journal of Clinical Endocrinology and Metabolism., 82, 3976-3981. – reference: Lafuente, A., Márquez, N., Pérez-Lorenzo, M. et al. (2000) Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food and Chemical Toxicology, 38, 913-923. – reference: Aitken, R.J. & Baker, M.A. (2013) Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development. International Journal of Developmental Biology, 57, 265-272. – reference: Foote, R.H. (1999) Fertility of rabbit sperm exposed in vitro to cadmium and lead. Reproductive Toxicology, 13, 443-449. – reference: Kakkar, P. & Jaffery, F.N. (2005) Biological markers for metal toxicity. Environmental Toxicology and Pharmacology, 19, 335-349. – reference: Diamanti-Kandarakis, E., Bourguignon, J.P., Giudice, L.C. et al. (2009) Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocrine Review, 30, 293-342. – reference: Wang, B. & Du, Y. (2013) Cadmium and its neurotoxic effects. Oxidative Medicine and Cellular Longevity 2013, 898034. Review. – reference: Interdonato, M., Bitto, A., Pizzino, G. et al. (2014) Levels of heavy metals in adolescents living in the industrialised area of milazzo-valle del mela (northern sicily). Journal of Environmental and Public Health, 2014, 326845. – reference: Kuczmarski, R.J., Ogden, C.L., Guo, S.S. et al. (2002) 2000 CDC growth charts for the United States: Methods and development. National Center for Health Statistics, Vital and Health Statistics Series. – reference: Bernhoft, R.A. (2013) Cadmium toxicity and treatment. Scientific World Journal 2013, 394652. Review. – reference: Ohtani, K., Yanagiba, Y., Ashimori, A. et al. (2013) Influence of injection timing on severity of cadmium-induced testicular toxicity in mice. Journal of Toxicological Sciences, 38, 145-150. – reference: Au, W.W.. (2002) Susceptibility of children to environmental toxic substances. International Journal of Hygiene and Environmental Health 205, 501-503. Review. – reference: Schulz, C., Wilhelm, M., Heudorf, U. et al. (2012) Update of the reference and HBM values derived by the German Human Biomonitoring Commission. International Journal of Hygiene and Environmental Health, 215, 149. – reference: Ademuyiwa, O., Agarwal, R., Chandra, R. et al. (2010) Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues. Journal of Trace Elements in Medicine and Biology, 24, 207-211. – reference: Liu, Q., Gu, J.H., Yuan, Y. et al. (2013) Effect of cadmium on rat Leydig cell testosterone production and DNA integrity in vitro. Biomedical and Environmental Sciences, 26, 769-773. – reference: Lafuente, A., González-Carracedo, A., Romero, A. et al. (2004) Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels. Toxicology Letters, 146, 175-182. – reference: Ji, Y.L., Wang, H., Liu, P. et al. (2010) Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice. Reproductive Toxicology, 29, 176-183. – reference: Pizzino, G., Bitto, A., Interdonato, M. et al. (2014) Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy). Redox Biology, 2, 686-693. – reference: Lafuente, A. & Esquifino, A.I. (1999) Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male. Toxicology Letters, 110, 209-218. – reference: Mazej, Z., Al Sayegh-Petkovsek, S. & Pokorny, B. (2010) Heavy metal concentrations in food chain of Lake Velenjsko jezero, Slovenia: an artificial lake from mining. Archives of Environmental Contamination and Toxicology, 58, 998-1007. – reference: Ciarrocca, M., Capozzella, A., Tomei, F. et al. (2013) Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone. Chemosphere, 90, 2077-2084. – reference: Lafuente, A., Márquez, N., Pérez-Lorenzo, M. et al. (2001) Cadmium effects on hypothalamic-pituitary-testicular axis in male rats. Experimental Biology and Medicine, 226, 605-611. – reference: Tanner, J.M. & Whitehouse, R.H. (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Archives of Disease in Childhood, 51, 170-179. – reference: Luca, G., Lilli, C., Bellocci, C. et al. (2013) Toxicity of cadmium on Sertoli cell functional competence: an in vitro study. Journal of Biological Regulators & Homeostatic Agents, 27, 805-816. – reference: Ho, C.K., Stoddart, M., Walton, M. et al. (2006) Calculated free testosterone in men: comparison of four equations and with free androgen index. Annals of clinical biochemistry, 43, 389-397. – volume: 24 start-page: 207 year: 2010 end-page: 211 article-title: Effects of sub‐chronic low‐level lead exposure on the homeostasis of copper and zinc in rat tissues publication-title: Journal of Trace Elements in Medicine and Biology – volume: 2014 start-page: 326845 year: 2014 article-title: Levels of heavy metals in adolescents living in the industrialised area of milazzo‐valle del mela (northern sicily) publication-title: Journal of Environmental and Public Health – volume: 30 start-page: 293 year: 2009 end-page: 342 article-title: Endocrine‐disrupting chemicals: an Endocrine Society scientific statement publication-title: Endocrine Review – volume: 215 start-page: 149 year: 2012 article-title: Update of the reference and HBM values derived by the German Human Biomonitoring Commission publication-title: International Journal of Hygiene and Environmental Health – volume: 58 start-page: 998 year: 2010 end-page: 1007 article-title: Heavy metal concentrations in food chain of Lake Velenjsko jezero, Slovenia: an artificial lake from mining publication-title: Archives of Environmental Contamination and Toxicology – volume: 2 start-page: 686 year: 2014 end-page: 693 article-title: Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo‐Valle del Mela area (Sicily, Italy) publication-title: Redox Biology – volume: 27 start-page: 805 year: 2013 end-page: 816 article-title: Toxicity of cadmium on Sertoli cell functional competence: an in vitro study publication-title: Journal of Biological Regulators & Homeostatic Agents – volume: 29 start-page: 176 year: 2010 end-page: 183 article-title: Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice publication-title: Reproductive Toxicology – volume: 110 start-page: 209 year: 1999 end-page: 218 article-title: Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male publication-title: Toxicology Letters – volume: 26 start-page: 769 year: 2013 end-page: 773 article-title: Effect of cadmium on rat Leydig cell testosterone production and DNA integrity in vitro publication-title: Biomedical and Environmental Sciences – volume: 38 start-page: 145 year: 2013 end-page: 150 article-title: Influence of injection timing on severity of cadmium‐induced testicular toxicity in mice publication-title: Journal of Toxicological Sciences – volume: 59 start-page: 395 year: 2013 end-page: 404 article-title: The hypothalamic‐pituitary‐gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches publication-title: Food and Chemical Toxicology – volume: 51 start-page: 170 year: 1976 end-page: 179 article-title: Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty publication-title: Archives of Disease in Childhood – volume: 2013 start-page: 898034 year: 2013 article-title: Cadmium and its neurotoxic effects publication-title: Oxidative Medicine and Cellular Longevity – volume: 13 start-page: 443 year: 1999 end-page: 449 article-title: Fertility of rabbit sperm exposed in vitro to cadmium and lead publication-title: Reproductive Toxicology – year: 2010 – volume: 146 start-page: 175 year: 2004 end-page: 182 article-title: Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels publication-title: Toxicology Letters – volume: 226 start-page: 605 year: 2001 end-page: 611 article-title: Cadmium effects on hypothalamic‐pituitary‐testicular axis in male rats publication-title: Experimental Biology and Medicine – volume: 90 start-page: 2077 year: 2013 end-page: 2084 article-title: Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone publication-title: Chemosphere – volume: 57 start-page: 265 year: 2013 end-page: 272 article-title: Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development publication-title: International Journal of Developmental Biology – year: 2002 – volume: 2013 start-page: 394652 year: 2013 article-title: Cadmium toxicity and treatment publication-title: Scientific World Journal – volume: 205 start-page: 501 year: 2002 end-page: 503 article-title: Susceptibility of children to environmental toxic substances publication-title: International Journal of Hygiene and Environmental Health – volume: 43 start-page: 389 year: 2006 end-page: 397 article-title: Calculated free testosterone in men: comparison of four equations and with free androgen index publication-title: Annals of clinical biochemistry – volume: 38 start-page: 913 year: 2000 end-page: 923 article-title: Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic‐pituitary‐testicular axis function in the rat publication-title: Food and Chemical Toxicology – volume: 19 start-page: 335 year: 2005 end-page: 349 article-title: Biological markers for metal toxicity publication-title: Environmental Toxicology and Pharmacology – volume: 172 start-page: 353 year: 2011 end-page: 365 article-title: Characterization of soil heavy metal contamination and potential health risk in metropolitan region of northern China publication-title: Environmental Monitoring and Assessment – volume: 82 start-page: 3976 year: 1997 end-page: 3981 article-title: Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle‐stimulating hormone, luteinizing hormone, testosterone, and estradiol levels publication-title: Journal of Clinical Endocrinology and Metabolism. – ident: e_1_2_6_8_1 doi: 10.1016/j.fct.2013.06.024 – ident: e_1_2_6_6_1 doi: 10.1007/s10661-010-1339-1 – ident: e_1_2_6_5_1 doi: 10.1007/s00244-009-9417-5 – ident: e_1_2_6_11_1 doi: 10.1155/2014/326845 – ident: e_1_2_6_13_1 doi: 10.1136/adc.51.3.170 – ident: e_1_2_6_10_1 doi: 10.1016/j.chemosphere.2012.10.060 – volume-title: 2000 CDC growth charts for the United States: Methods and development year: 2002 ident: e_1_2_6_14_1 – ident: e_1_2_6_29_1 doi: 10.1210/jc.82.12.3976 – ident: e_1_2_6_25_1 doi: 10.1016/S0890-6238(99)00045-3 – ident: e_1_2_6_12_1 doi: 10.1016/j.redox.2014.05.003 – ident: e_1_2_6_7_1 doi: 10.1387/ijdb.130146ja – ident: e_1_2_6_2_1 doi: 10.1016/j.jtemb.2010.01.002 – volume: 26 start-page: 769 year: 2013 ident: e_1_2_6_21_1 article-title: Effect of cadmium on rat Leydig cell testosterone production and DNA integrity in vitro publication-title: Biomedical and Environmental Sciences – ident: e_1_2_6_24_1 doi: 10.1155/2013/898034 – ident: e_1_2_6_28_1 doi: 10.1016/S0378-4274(99)00159-9 – ident: e_1_2_6_18_1 doi: 10.1155/2013/394652 – ident: e_1_2_6_17_1 doi: 10.1016/j.ijheh.2012.01.003 – ident: e_1_2_6_16_1 – ident: e_1_2_6_20_1 doi: 10.1016/j.reprotox.2009.10.014 – ident: e_1_2_6_4_1 doi: 10.1210/er.2009-0002 – ident: e_1_2_6_19_1 doi: 10.1078/1438-4639-00179 – ident: e_1_2_6_3_1 doi: 10.1016/j.etap.2004.09.003 – ident: e_1_2_6_23_1 doi: 10.2131/jts.38.145 – ident: e_1_2_6_27_1 doi: 10.1016/j.toxlet.2003.10.004 – ident: e_1_2_6_26_1 doi: 10.1177/153537020122600615 – ident: e_1_2_6_9_1 doi: 10.1016/S0278-6915(00)00077-6 – ident: e_1_2_6_15_1 – volume: 27 start-page: 805 year: 2013 ident: e_1_2_6_22_1 article-title: Toxicity of cadmium on Sertoli cell functional competence: an in vitro study publication-title: Journal of Biological Regulators & Homeostatic Agents – ident: e_1_2_6_30_1 doi: 10.1258/000456306778520115 |
| SSID | ssj0005807 |
| Score | 2.3198068 |
| Snippet | Summary
Objective
Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with... Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary... Summary Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with... Objective Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 357 |
| SubjectTerms | Adolescent Cadmium - urine Child Cross-Sectional Studies Follicle Stimulating Hormone - blood Humans Inhibins - blood Linear Models Luteinizing Hormone - blood Male Organ Size - physiology Puberty - blood Puberty - physiology Puberty - urine Testis - growth & development Testosterone - blood Time Factors Urban Health - statistics & numerical data Urban Population - statistics & numerical data |
| Title | Cadmium delays puberty onset and testis growth in adolescents |
| URI | https://api.istex.fr/ark:/67375/WNG-3D0B7DPJ-3/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcen.12704 https://www.ncbi.nlm.nih.gov/pubmed/25521350 https://www.proquest.com/docview/1707495262 https://www.proquest.com/docview/1708160869 https://www.proquest.com/docview/1855074820 |
| Volume | 83 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS91AEB5EQfpSb22NN7YixZcc9OwlCeKDHm8IHqRU6kNh2Ww2KmoUTw6ov96ZzcULWkrfQjIJs5Od3e_Lzn4BWMkdnheRDUUukKDEMg2N4TzMY8GtiHEGMbR3-KivDk7E4ak8HYGNZi9MpQ_RfnCjzPDjNSW4SQcvkty6okPLpqQFSrVaBIh-PktHyXqrNKed00qJWlWIqnjaO1_NRWMU1vv3gOZr3Oonnr0J-NO4XNWbXHaGZdqxj2_UHP-zTZPwuQakbKvqQVMw4oppGD-ql9xnYLNnsuuL4TUjOcmHAUNnSY6XURV2yUyRsZKEOgbsDAl9ec4uCvZCJeoLnOzt_uodhPU_F0Iru4kIcxFxF3ErU-GQv5ouIkSbiUQlCBVwbMgQD_JcIMo1aY7klmdrylnyOct4bjn_CqPFTeFmgWXIu02EGW8FPsyqmFvkfgiJVGQljiUBrDbR17YWJKf_Ylzphpigo9qHI4Dl1vS2UuF4z-iHf4Wthbm7pLK1SOrf_X3Nd9a2o53jQ80DWGjesa4zdqDXIwRTieyqbgDf28uYa7SAYgp3M_Q28bpCEpj8xcYrxAmMVgDfqv7TOoT0DeMp8cqq7wUft0X3dvv-YO7fTefhE6I5WRXALcBoeTd0i4iYynTJp8YTyu4M8Q |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dT9RAEJ_wkYAvKiBYQVkMMbz0ArcfbRN90DvgQO5iDERezGa73SpBiuF6CfrXO7P9EAwaw1vTTpvpdGf39-vO_hZgM3d4XkQ2FLlAghLLNDSG8zCPBbcixhHE0Nrh4UgNTsThqTydgtfNWphKH6L94UaZ4ftrSnD6IX0jy60rOjRvKqZhlnb0JuX8_sff4lGyXizNae20UqLWFaI6nvbWW6PRLAX2-i6oeRu5-qFn7xF8bpyuKk7OO5My7diff-g53vetHsPDGpOyt1UjWoApVyzC3LCedV-CNz2TXZxNLhgpSv4YM_SWFHkZFWKXzBQZK0mrY8y-IKcvv7Kzgt0QinoCJ3u7x71BWG-7EFrZTUSYi4i7iFuZCocU1nQRJNpMJCpBtIDdQ4aQkOcCga5Jc-S3PNtWzpLPWcZzy_kyzBSXhXsKLEPqbSJMeivwYVbF3CL9Q1SkIiuxOwlgqwm_trUmOW2N8U033AQd1T4cAbxsTb9XQhx3Gb3y37C1MFfnVLkWSf1ptK95f_td1P9wqHkAa81H1nXSjvVOhHgqkV3VDWCjvYzpRnMopnCXE28T7yjkgck_bLxInMBoBbBSNaDWIWRwGE-JV7Z8M_j7u-je7sgfPPt_03WYHxwPj_TRwej9KjxAcCererg1mCmvJu45AqgyfeHz5BebqhEN |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB7xkBCXPijQUGjdqkJcslrWjySqeii7LJSWFUIg9oBkObYDCAiIzUptf33HzqOAAKHeomQSTSYe-_vi8WeAz5nF8yzSIcsYEpSYp6FSlIZZzKhmMY4gyq0d3h2I7UO2M-TDCfhSr4Up9SGaH24uM3x_7RL82mS3klzbvOWmTdkkTDPRTty-Db39f9pRvForTd3SaSFYJSvkyniaW-8MRtMurr8eQpp3gasfefov4bj2uSw4OW-Ni7Sl_9yTc_zPl3oFLypESr6VTeg1TNh8DmZ2qzn3N_C1q8zl2fiSOD3J3yOCzjo9XuLKsAuickMKp9QxIifI6ItTcpaTWzJR83DY3zzobofVpguh5p2EhRmLqI2o5imzSGBVByGiNiwRCWIF7BwMAkKaMYS5Ks2Q3VLTFlY7n42hmaZ0Aabyq9y-BWKQeKsIU14zfJgWMdVI_hATiUhz7EwCWKujL3WlSO42xriQNTNBR6UPRwCfGtPrUobjIaNV_wkbC3Vz7urWIi6PBluS9tobUW9vR9IAlutvLKuUHcn1CNFUwjuiE8DH5jImm5tBUbm9GnubeF0gC0yesPEScQyjFcBi2X4ah5C_YTw5XlnzreDxd5HdzYE_WHq-6QeY2ev15c_vgx_vYBaRHS-L4ZZhqrgZ2xVET0X63mfJX1NvD7w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cadmium+delays+puberty+onset+and+testis+growth+in+adolescents&rft.jtitle=Clinical+endocrinology+%28Oxford%29&rft.au=Interdonato%2C+Monica&rft.au=Pizzino%2C+Gabriele&rft.au=Bitto%2C+Alessandra&rft.au=Galfo%2C+Federica&rft.date=2015-09-01&rft.issn=0300-0664&rft.eissn=1365-2265&rft.volume=83&rft.issue=3&rft.spage=357&rft.epage=362&rft_id=info:doi/10.1111%2Fcen.12704&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_cen_12704 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-0664&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-0664&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-0664&client=summon |