Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis

• Published in: The journal of clinical endocrinology and metabolism Vol. 104; no. 7; pp. 2685 - 2694
• Main Authors: Mezza, Teresa, Moffa, Simona, Ferraro, Pietro Manuel, Quero, Giuseppe, Capece, Umberto, Carfì, Andrea, Cefalo, Chiara M A, Cinti, Francesca, Sorice, Gian Pio, Impronta, Flavia, Mari, Andrea, Pontecorvi, Alfredo, Alfieri, Sergio, Holst, Jens J, Giaccari, Andrea
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.07.2019; Copyright Oxford University Press; Oxford University Press
• Subjects: Analysis; Beta cells; Bile; Bilirubin; Cholestasis; Dextrose; Diabetes mellitus; Ethylenediaminetetraacetic acid; Fasting; Gallbladder diseases; Gastrointestinal surgery; GIP protein; Glucagon; Glucagon-like peptide 1; Glucose; Glucose tolerance; Glucose tolerance tests; Insulin; Insulin secretion; Jaundice, Obstructive; Laboratory testing; Obesity; Pancreas; Physiological aspects; Remission; Secretion; Surgery; Tumors; Type 2 diabetes

Abstract Objective Changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins, leading to diabetes remission. However, the exact mechanism(s) involved is still unclear. Here, we propose an alternative method to investigate the relationship between alter...