A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity

• Published in: Advanced science Vol. 9; no. 4; pp. e2103265 - n/a
• Main Authors: Chovsepian, Alexandra, Berchtold, Daniel, Winek, Katarzyna, Mamrak, Uta, Ramírez Álvarez, Inés, Dening, Yanina, Golubczyk, Dominika, Weitbrecht, Luis, Dames, Claudia, Aillery, Marine, Fernandez‐Sanz, Celia, Gajewski, Zdzislaw, Dieterich, Marianne, Janowski, Miroslaw, Falkai, Peter, Walczak, Piotr, Plesnila, Nikolaus, Meisel, Andreas, Pan‐Montojo, Francisco
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.02.2022; John Wiley and Sons Inc; Wiley
• Subjects: Acids; Apoptosis; Free radicals; Glucose; glutamate‐dependent excitotoxicity; Ischemia; ischemia–reperfusion damage; Metabolism; neuroprotection; Stroke; Variance analysis; glutamate-dependent excitotoxicity; Stroke; ischemia-reperfusion damage; neuroprotection

Stroke is the second leading cause of death and disability worldwide. Current treatments, such as pharmacological thrombolysis or mechanical thrombectomy, reopen occluded arteries but do not protect against ischemia‐induced damage that occurs before reperfusion or neuronal damage induced by ischemia...