Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): Technical recommendations for the use of Short Tandem Repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping Chimerism Working Group
Summary Analysis of short tandem repeats (STR) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of disease relapse, level of engraftment and provide useful information on the graft‐versus‐host disease (GVHD)/graft‐versus‐tumour (GVT) effect...
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Published in | British journal of haematology Vol. 168; no. 1; pp. 26 - 37 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.01.2015
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Subjects | |
Online Access | Get full text |
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Abstract | Summary
Analysis of short tandem repeats (STR) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of disease relapse, level of engraftment and provide useful information on the graft‐versus‐host disease (GVHD)/graft‐versus‐tumour (GVT) effect, facilitating therapeutic intervention. Harmonization and standardization of techniques and result interpretation is essential to reduce the impact of laboratory variability on both clinical management and the results of multi‐centre clinical trials. However, the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping (UK NEQAS LI) has highlighted significant issues inherent in STR testing that impact upon inter‐ and intra‐ laboratory variation. We present here consensus best practice guidelines and recommendations for STR chimerism testing, data interpretation and reporting that have been drawn up and agreed by a consortium of 11 UK and Eire clinical laboratories. This document uses data obtained from the UK NEQAS LI Post‐Stem Cell Transplant (SCT) Chimerism Monitoring Programme. |
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AbstractList | Summary
Analysis of short tandem repeats (STR) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of disease relapse, level of engraftment and provide useful information on the graft‐versus‐host disease (GVHD)/graft‐versus‐tumour (GVT) effect, facilitating therapeutic intervention. Harmonization and standardization of techniques and result interpretation is essential to reduce the impact of laboratory variability on both clinical management and the results of multi‐centre clinical trials. However, the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping (UK NEQAS LI) has highlighted significant issues inherent in STR testing that impact upon inter‐ and intra‐ laboratory variation. We present here consensus best practice guidelines and recommendations for STR chimerism testing, data interpretation and reporting that have been drawn up and agreed by a consortium of 11 UK and Eire clinical laboratories. This document uses data obtained from the UK NEQAS LI Post‐Stem Cell Transplant (SCT) Chimerism Monitoring Programme. Analysis of short tandem repeats (STR) is the predominant method for post-transplant monitoring of donor engraftment. It can enable early detection of disease relapse, level of engraftment and provide useful information on the graft-versus-host disease (GVHD)/graft-versus-tumour (GVT) effect, facilitating therapeutic intervention. Harmonization and standardization of techniques and result interpretation is essential to reduce the impact of laboratory variability on both clinical management and the results of multi-centre clinical trials. However, the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping (UK NEQAS LI) has highlighted significant issues inherent in STR testing that impact upon inter- and intra- laboratory variation. We present here consensus best practice guidelines and recommendations for STR chimerism testing, data interpretation and reporting that have been drawn up and agreed by a consortium of 11 UK and Eire clinical laboratories. This document uses data obtained from the UK NEQAS LI Post-Stem Cell Transplant (SCT) Chimerism Monitoring Programme. Summary Analysis of short tandem repeats ( STR ) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of disease relapse, level of engraftment and provide useful information on the graft‐versus‐host disease ( GVHD )/graft‐versus‐tumour ( GVT ) effect, facilitating therapeutic intervention. Harmonization and standardization of techniques and result interpretation is essential to reduce the impact of laboratory variability on both clinical management and the results of multi‐centre clinical trials. However, the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping ( UK NEQAS LI ) has highlighted significant issues inherent in STR testing that impact upon inter‐ and intra‐ laboratory variation. We present here consensus best practice guidelines and recommendations for STR chimerism testing, data interpretation and reporting that have been drawn up and agreed by a consortium of 11 UK and Eire clinical laboratories. This document uses data obtained from the UK NEQAS LI Post‐Stem Cell Transplant ( SCT ) Chimerism Monitoring Programme. |
Author | Sproul, Anne Clouston, Hazel Barnett, David Jack, Andrea L. Jackson, Tony Reilly, John T. Clark, Jordan R. Carter, Geoffrey I. Pearce, Laurence Lee, Helena Folarin, Najeem'deen Scott, Stuart D. Molloy, Karen Snowden, John A. Mason, Joanne Whitby, Liam Keen, Leigh |
Author_xml | – sequence: 1 givenname: Jordan R. surname: Clark fullname: Clark, Jordan R. organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 2 givenname: Stuart D. surname: Scott fullname: Scott, Stuart D. organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 3 givenname: Andrea L. surname: Jack fullname: Jack, Andrea L. organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 4 givenname: Helena surname: Lee fullname: Lee, Helena organization: Central Manchester University Hospitals NHS Foundation Trust – sequence: 5 givenname: Joanne surname: Mason fullname: Mason, Joanne organization: Birmingham's Women's NHS Foundation Trust – sequence: 6 givenname: Geoffrey I. surname: Carter fullname: Carter, Geoffrey I. organization: Nottingham University Hospitals NHS Trust – sequence: 7 givenname: Laurence surname: Pearce fullname: Pearce, Laurence organization: Nottingham University Hospitals NHS Trust – sequence: 8 givenname: Tony surname: Jackson fullname: Jackson, Tony organization: The Newcastle upon Tyne Hospitals NHS Foundation Trust – sequence: 9 givenname: Hazel surname: Clouston fullname: Clouston, Hazel organization: Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust – sequence: 10 givenname: Anne surname: Sproul fullname: Sproul, Anne organization: Western General Hospital – sequence: 11 givenname: Leigh surname: Keen fullname: Keen, Leigh organization: NHS Blood and Transplant – sequence: 12 givenname: Karen surname: Molloy fullname: Molloy, Karen organization: St James Hospital – sequence: 13 givenname: Najeem'deen surname: Folarin fullname: Folarin, Najeem'deen organization: King's College Hospital NHS Foundation Trust – sequence: 14 givenname: Liam surname: Whitby fullname: Whitby, Liam organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 15 givenname: John A. surname: Snowden fullname: Snowden, John A. organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 16 givenname: John T. surname: Reilly fullname: Reilly, John T. organization: Sheffield Teaching Hospitals NHS Foundation Trust – sequence: 17 givenname: David surname: Barnett fullname: Barnett, David organization: Sheffield Teaching Hospitals NHS Foundation Trust |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25145701$$D View this record in MEDLINE/PubMed |
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Analysis of short tandem repeats (STR) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection of... Analysis of short tandem repeats (STR) is the predominant method for post-transplant monitoring of donor engraftment. It can enable early detection of disease... Summary Analysis of short tandem repeats ( STR ) is the predominant method for post‐transplant monitoring of donor engraftment. It can enable early detection... |
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SubjectTerms | allogeneic haematopoietic stem cell transplantation Chimerism Genetic Testing - methods Genetic Testing - standards guidelines Hematopoietic Stem Cell Transplantation Humans Microsatellite Repeats short tandem repeats Transplantation Chimera - genetics Transplantation, Homologous Watchful Waiting |
Title | Monitoring of chimerism following allogeneic haematopoietic stem cell transplantation (HSCT): Technical recommendations for the use of Short Tandem Repeat (STR) based techniques, on behalf of the United Kingdom National External Quality Assessment Service for Leucocyte Immunophenotyping Chimerism Working Group |
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