Oxygen‐Independent Sulfate Radical for Stimuli‐Responsive Tumor Nanotherapy
Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2O2) in tumor microenvironments inevitably hinder the effective production o...
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| Published in | Advanced science Vol. 9; no. 17; pp. e2200974 - n/a |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Germany
John Wiley & Sons, Inc
01.06.2022
John Wiley and Sons Inc Wiley |
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| Abstract | Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2O2) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5−)‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4−)‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4−. Different from conventional ROS, the emergence of •SO4−, possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O2) and H2O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine.
The CuS@PMS nanosystems with multiple theranostic functions are maneuverable in stimuli‐responsive sulfate radical‐mediated nanotherapy against melanoma in an oxygen‐independent manner, competent in photoacoustic imaging and precipitating skin regeneration. The high‐performance sulfate radical tumor therapy is implemented via exploiting the outstanding oxidation property of sulfate radical and inducing synergistic activation by photothermal effect and copper ions. |
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| AbstractList | Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2O2) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5−)‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4−)‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4−. Different from conventional ROS, the emergence of •SO4−, possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O2) and H2O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine.
The CuS@PMS nanosystems with multiple theranostic functions are maneuverable in stimuli‐responsive sulfate radical‐mediated nanotherapy against melanoma in an oxygen‐independent manner, competent in photoacoustic imaging and precipitating skin regeneration. The high‐performance sulfate radical tumor therapy is implemented via exploiting the outstanding oxidation property of sulfate radical and inducing synergistic activation by photothermal effect and copper ions. Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H 2 O 2 ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO 5 − )‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO 4 − )‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO 4 − . Different from conventional ROS, the emergence of •SO 4 − , possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O 2 ) and H 2 O 2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine. Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H 2 O 2 ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO 5 − )‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO 4 − )‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO 4 − . Different from conventional ROS, the emergence of •SO 4 − , possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O 2 ) and H 2 O 2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine. The CuS@PMS nanosystems with multiple theranostic functions are maneuverable in stimuli‐responsive sulfate radical‐mediated nanotherapy against melanoma in an oxygen‐independent manner, competent in photoacoustic imaging and precipitating skin regeneration. The high‐performance sulfate radical tumor therapy is implemented via exploiting the outstanding oxidation property of sulfate radical and inducing synergistic activation by photothermal effect and copper ions. Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H O ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO )-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO )-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO . Different from conventional ROS, the emergence of •SO , possessing a longer half-life and more rapid reaction, is independent of the oxygen (O ) and H O content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli-responsive nanosystems in biomedicine. Abstract Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2O2) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5−)‐loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4−)‐mediated and stimuli‐responsive tumor nanotherapy in an oxygen‐independent manner. In this therapeutic modality, the second near‐infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4−. Different from conventional ROS, the emergence of •SO4−, possessing a longer half‐life and more rapid reaction, is independent of the oxygen (O2) and H2O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli‐responsive nanosystems in biomedicine. Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2O2) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5−)-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4−)-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4−. Different from conventional ROS, the emergence of •SO4−, possessing a longer half-life and more rapid reaction, is independent of the oxygen (O2) and H2O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli-responsive nanosystems in biomedicine. Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2 O2 ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5- )-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4- )-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4- . Different from conventional ROS, the emergence of •SO4- , possessing a longer half-life and more rapid reaction, is independent of the oxygen (O2 ) and H2 O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli-responsive nanosystems in biomedicine.Variant modalities are quested and merged into the tumor nanotherapy by leveraging the excitation from external or intratumoral incentives. However, the ubiquitous hypoxia and the insufficient content of hydrogen peroxide (H2 O2 ) in tumor microenvironments inevitably hinder the effective production of reactive oxygen species (ROS). To radically extricate from the shackles, peroxymonosulfate (PMS: HSO5- )-loaded hollow mesoporous copper sulfide (CuS) nanoparticles (NPs) are prepared as the distinct ROS donors for sulfate radical (•SO4- )-mediated and stimuli-responsive tumor nanotherapy in an oxygen-independent manner. In this therapeutic modality, the second near-infrared laser irradiation, together with the released copper ions as well as the heat produced by CuS after illumination, work together to activate PMS thus triply ensuring the copious production of •SO4- . Different from conventional ROS, the emergence of •SO4- , possessing a longer half-life and more rapid reaction, is independent of the oxygen (O2 ) and H2 O2 content within the tumor. In addition, this engineered nanosystem also exerts the function of photoacoustic imaging and skin restoration on the corresponding animal models. This study reveals the enormous potential of sulfate radical in oncotherapy and broadens pave for exploring the application of multifunctional and stimuli-responsive nanosystems in biomedicine. |
| Author | Ding, Dandan Zhou, Jianqiao Mei, Zihan Chen, Liang Feng, Wei Huang, Hui Chen, Yu |
| AuthorAffiliation | 4 Wenzhou Institute of Shanghai University Wenzhou 325000 P. R. China 2 Shanghai Engineering Research Center of Organ Repair Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China 3 School of Medicine Shanghai University Shanghai 200444 P. R. China 1 Department of Ultrasound Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 P. R. China |
| AuthorAffiliation_xml | – name: 3 School of Medicine Shanghai University Shanghai 200444 P. R. China – name: 1 Department of Ultrasound Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 P. R. China – name: 2 Shanghai Engineering Research Center of Organ Repair Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China – name: 4 Wenzhou Institute of Shanghai University Wenzhou 325000 P. R. China |
| Author_xml | – sequence: 1 givenname: Dandan surname: Ding fullname: Ding, Dandan organization: Shanghai Jiaotong University School of Medicine – sequence: 2 givenname: Zihan surname: Mei fullname: Mei, Zihan organization: Shanghai Jiaotong University School of Medicine – sequence: 3 givenname: Hui surname: Huang fullname: Huang, Hui email: huanghuish@shu.edu.cn organization: Shanghai University – sequence: 4 givenname: Wei surname: Feng fullname: Feng, Wei organization: Shanghai University – sequence: 5 givenname: Liang surname: Chen fullname: Chen, Liang organization: Shanghai University – sequence: 6 givenname: Yu orcidid: 0000-0002-8206-3325 surname: Chen fullname: Chen, Yu email: chenyuedu@shu.edu.cn organization: Wenzhou Institute of Shanghai University – sequence: 7 givenname: Jianqiao surname: Zhou fullname: Zhou, Jianqiao email: zjq11432@rjh.com.cn organization: Shanghai Jiaotong University School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35488513$$D View this record in MEDLINE/PubMed |
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| Keywords | melanoma ulfate radical skin tissue healing reactive oxygen species (ROS) stimuli-responsive |
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| SubjectTerms | Animals Copper Lasers Light Melanoma Morphology Neoplasms - therapy Oxygen Reactive Oxygen Species reactive oxygen species (ROS) skin tissue healing Spectrum analysis stimuli‐responsive Sulfates Tumor Microenvironment Tumors ulfate radical |
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| Title | Oxygen‐Independent Sulfate Radical for Stimuli‐Responsive Tumor Nanotherapy |
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