Ocular Nanomedicine

Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and na...

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Published inAdvanced science Vol. 9; no. 15; pp. e2003699 - n/a
Main Authors Tang, Zhimin, Fan, Xianqun, Chen, Yu, Gu, Ping
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.05.2022
John Wiley and Sons Inc
Wiley
Subjects
Bioavailability
Biomedical materials
Blood vessels
diagnostics
Disease
Glaucoma
Hydrogels
Lipids
Monoclonal antibodies
Nanomaterials
nanomedicine
Nanomedicine - methods
Nanoparticles
Nanostructures - chemistry
ocular
Ophthalmology
Quantum dots
Review
Reviews
therapeutics
Tissue Distribution
Tumor necrosis factor-TNF
nanomedicine
diagnostics
therapeutics
ophthalmology
ocular
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Abstract Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state‐of‐the‐art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of “ocular nanomedicine.” By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine‐based fundamental research and future clinical translation. The distinctive functional ocular nanomedicine as potential alternatives for satisfying the requirements of abundant ophthalmologic applications has been comprehensively overviewed. In this comprehensive review, the authors summarize, discuss and highlight the fundamental principles on the design, fabrication, and ophthalmologic application of distinctive ocular nanomedicine, and provide an overview and deep discussion on the nano‐enabled amalgamation of ophthalmology, material chemistry, biology, and medicine.
AbstractList Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state-of-the-art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of "ocular nanomedicine." By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.
Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state‐of‐the‐art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of “ocular nanomedicine.” By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine‐based fundamental research and future clinical translation. The distinctive functional ocular nanomedicine as potential alternatives for satisfying the requirements of abundant ophthalmologic applications has been comprehensively overviewed. In this comprehensive review, the authors summarize, discuss and highlight the fundamental principles on the design, fabrication, and ophthalmologic application of distinctive ocular nanomedicine, and provide an overview and deep discussion on the nano‐enabled amalgamation of ophthalmology, material chemistry, biology, and medicine.
Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state-of-the-art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of "ocular nanomedicine." By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state-of-the-art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of "ocular nanomedicine." By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.
Abstract Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state‐of‐the‐art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of “ocular nanomedicine.” By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine‐based fundamental research and future clinical translation.
Author Tang, Zhimin
Fan, Xianqun
Chen, Yu
Gu, Ping
AuthorAffiliation 1 Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011 P. R. China
2 Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China
AuthorAffiliation_xml – name: 1 Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011 P. R. China
– name: 2 Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China
Author_xml – sequence: 1
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  organization: Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology
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  fullname: Fan, Xianqun
  organization: Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology
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  orcidid: 0000-0002-8206-3325
  surname: Chen
  fullname: Chen, Yu
  email: chenyuedu@shu.edu.cn
  organization: Shanghai University
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  givenname: Ping
  surname: Gu
  fullname: Gu, Ping
  email: guping2009@sjtu.edu.cn
  organization: Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35150092$$D View this record in MEDLINE/PubMed
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Issue 15
Keywords nanomedicine
diagnostics
therapeutics
ophthalmology
ocular
Language English
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2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Snippet Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid...
Abstract Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting...
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StartPage e2003699
SubjectTerms Bioavailability
Biomedical materials
Blood vessels
diagnostics
Disease
Glaucoma
Hydrogels
Lipids
Monoclonal antibodies
Nanomaterials
nanomedicine
Nanomedicine - methods
Nanoparticles
Nanostructures - chemistry
ocular
Ophthalmology
Quantum dots
Review
Reviews
therapeutics
Tissue Distribution
Tumor necrosis factor-TNF
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Title Ocular Nanomedicine
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fadvs.202003699
https://www.ncbi.nlm.nih.gov/pubmed/35150092
https://www.proquest.com/docview/2668703351
https://www.proquest.com/docview/2628296842
https://pubmed.ncbi.nlm.nih.gov/PMC9130902
https://doaj.org/article/0521fdc0736a427e9c5e94027deb736b
Volume 9
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