Telocytes in human isolated atrial amyloidosis: ultrastructural remodelling

• Published in: Journal of cellular and molecular medicine Vol. 14; no. 12; pp. 2739 - 2747
• Main Authors: Mandache, E., Gherghiceanu, M., Macarie, C., Kostin, S., Popescu, L. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2010; John Wiley & Sons, Inc
• Subjects: Adult; Aged; Amyloid - analysis; Amyloidosis; Amyloidosis - pathology; Appendages; Atrial Appendage - pathology; atrial fibrillation; Atrial Fibrillation - pathology; Atrial Natriuretic Factor; atrial natriuretic peptide; Biopsy; Cardiac arrhythmia; Cardiomyocytes; Cardiomyopathies - pathology; Cells, Cultured; Cytoplasm; Electron microscopes; Electron microscopy; Female; Fibrils; Filaments; Heart; Heart Atria - pathology; Heart surgery; Human subjects; Humans; interstitial Cajal‐like cells; Interstitial Cells of Cajal - pathology; Interstitial Cells of Cajal - ultrastructure; isolated atrial amyloidosis; Localization; Male; Microscopy; Microscopy, Electron; Middle Aged; Myocytes, Cardiac - ultrastructure; Pathogenesis; Pathology; Peptides; Plaque, Amyloid; Proteins; Stromal Cells - pathology; Stromal Cells - ultrastructure; telocytes; telopodes; Ultrastructure; Germany

The human heart can be frequently affected by an organ‐limited amyloidosis called isolated atrial amyloidosis (IAA). IAA is a frequent histopathological finding in patients with long‐standing atrial fibrillation (AF). The aim of this paper was to investigate the ultrastructure of cardiomyocytes and...