SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus

• Published in: Advanced science Vol. 9; no. 34; pp. e2203088 - n/a
• Main Authors: Li, Qiuchen, Jiang, Zhimin, Ren, Shuning, Guo, Hui, Song, Zhimin, Chen, Saini, Gao, Xintao, Meng, Fanfeng, Zhu, Junda, Liu, Litao, Tong, Qi, Sun, Honglei, Sun, Yipeng, Pu, Juan, Chang, Kin‐Chow, Liu, Jinhua
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2022; John Wiley and Sons Inc; Wiley
• Subjects: Alternative Splicing; anidulafungin; Animals; Experiments; Genes; Infections; Influenza; Influenza A virus; influenza A viruses; Kinases; Mice; Orthomyxoviridae Infections; Pandemics; Plasmids; Protein expression; Proteins; RNA, Messenger; Severe acute respiratory syndrome coronavirus 2; SRSF5; U1 snRNP; Virus Replication; Viruses; influenza A viruses; anidulafungin; SRSF5; alternative splicing; U1 snRNP

Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated viral replication by enhancing viral M mRNA splic...