Large Oncosome‐Loaded VAPA Promotes Bone‐Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre‐Metastatic Niche

• Published in: Advanced science Vol. 9; no. 31; pp. e2201974 - n/a
• Main Authors: Zhang, Shuxia, Liao, Xinyi, Chen, Suwen, Qian, Wanying, Li, Man, Xu, Yingru, Yang, Meisongzhu, Li, Xincheng, Mo, Shuang, Tang, Miaoling, Wu, Xingui, Hu, Yameng, Li, Ziwen, Yu, Ruyuan, Abudourousuli, Ainiwaerjiang, Song, Libing, Li, Jun
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.11.2022; John Wiley and Sons Inc; Wiley
• Subjects: bone metastasis; Bone Neoplasms; Carcinoma, Hepatocellular; Communication; Experiments; hepatocellular carcinoma; Humans; Liver cancer; Liver Neoplasms; Metastasis; osteoclastic pre‐metastatic niche; Osteoclasts - metabolism; Osteoclasts - pathology; Physiology; Proteins; Signal Transduction; Staphylococcal Protein A; Transmission electron microscopy; Tumor Microenvironment; Tumors; VAMP‐associated protein A (VAPA); osteoclastic pre-metastatic niche; VAMP-associated protein A (VAPA); bone metastasis; hepatocellular carcinoma

Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis. Identifying the organ‐specific molecular determinants of EVs can develop potential...