Thiolated Mesoporous Silica Nanoparticles as an Immunoadjuvant to Enhance Efficacy of Intravesical Chemotherapy for Bladder Cancer

• Published in: Advanced science Vol. 10; no. 7; pp. e2204643 - n/a
• Main Authors: Chen, Cheng‐Che, Fa, Yu‐Chen, Kuo, Yen‐Yu, Liu, Yi‐Chun, Lin, Chih‐Yu, Wang, Xin‐Hui, Lu, Yu‐Huan, Chiang, Yu‐Han, Yang, Chia‐Min, Wu, Li‐Chen, Ho, Ja‐an Annie
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2023; John Wiley and Sons Inc; Wiley
• Subjects: Adjuvants, Immunologic - therapeutic use; Animals; Antibiotics, Antineoplastic; Bladder cancer; Cancer therapies; Chemotherapy; Glycoproteins; Immunotherapy; intravesical therapy; mesoporous silica nanoparticle; Mitomycin - therapeutic use; mitomycin C; Morphology; Nanoparticles; Nitrogen; Silicon Dioxide; Swine; thiol modification; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology; Urine; mitomycin C; mesoporous silica nanoparticle; intravesical therapy; thiol modification; bladder cancer

The characteristics of global prevalence and high recurrence of bladder cancer has led numerous efforts to develop new treatments. The spontaneous voiding and degradation of the chemodrug hamper the efficacy and effectiveness of intravesical chemotherapy following tumor resection. Herein, the extern...