Protein relative abundance patterns associated with sucrose-induced dysbiosis are conserved across taxonomically diverse oral microcosm biofilm models of dental caries

• Published in: Microbiome Vol. 3; no. 1; p. 69
• Main Authors: Rudney, Joel D., Jagtap, Pratik D., Reilly, Cavan S., Chen, Ruoqiong, Markowski, Todd W., Higgins, LeeAnn, Johnson, James E., Griffin, Timothy J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.12.2015; BioMed Central
• Subjects: Analysis; Bacterial Proteins - analysis; Biofilms - drug effects; Biofilms - growth & development; Biomarkers; Dental caries; Dental Caries - etiology; Dental Caries - microbiology; Dental Caries - prevention & control; Dental Plaque - chemistry; Dental Plaque - microbiology; Dysbiosis - chemically induced; Dysbiosis - metabolism; Dysbiosis - microbiology; Glucose metabolism; Glycolysis - drug effects; Humans; Microbial Consortia - drug effects; Microbial Consortia - genetics; Microbial Consortia - physiology; Microbiota (Symbiotic organisms); Microbiota - drug effects; Microbiota - genetics; Microbiota - physiology; Physiological aspects; Proteins; Proteins - analysis; Proteomics; RNA; RNA, Ribosomal, 16S - genetics; Saliva - microbiology; Sucrose - administration & dosage; Sucrose - pharmacology; Sugars

The etiology of dental caries is multifactorial, but frequent consumption of free sugars, notably sucrose, appears to be a major factor driving the supragingival microbiota in the direction of dysbiosis. Recent 16S rRNA-based studies indicated that caries-associated communities were less diverse tha...