The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity

• Published in: Frontiers in endocrinology (Lausanne) Vol. 9; p. 752
• Main Authors: Gladding, Joanne M, Abbott, Kirsten N, Antoniadis, Christopher P, Stuart, Angela, Begg, Denovan P
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.12.2018
• Subjects: diet induced obesity; Endocrinology; high fat diet; hippocampus; insulin; spatial cognition; spatial cognition; diet induced obesity; hippocampus; insulin; high fat diet

Obesity and high fat diet consumption contribute to the development of metabolic disorders, insulin resistance, neuroinflammation, and cognitive impairments. CNS administration of insulin into the brain can attenuate these cognitive impairments. The present study investigated whether hippocampal-dep...