Regulation of NLRP3 Inflammasome by Phosphorylation

• Published in: Frontiers in immunology Vol. 9; p. 2305
• Main Authors: Song, Nan, Li, Tao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.10.2018
• Subjects: Immunology; inflammasome; innate immunity; kinase; NLRP3; phosphatase; phosphorylation; NLRP3; kinase; phosphatase; innate immunity; phosphorylation; inflammasome

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Upon activation, NLRP3 triggers the assembly of inflammasome via the se...