Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients
Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screen...
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| Published in | Frontiers in immunology Vol. 7; p. 202 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
24.05.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-3224 1664-3224 |
| DOI | 10.3389/fimmu.2016.00202 |
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| Abstract | Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease.
Our study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors.
The current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay.
We found significant association of HLA-DP rs3077 AA, HLA-DQ rs3920 GG, ICAM-1 rs1437 CC, and CT genotypes with increased risk of ovarian cancer (OR = 43.5, 6, 25, and 2.6, respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P = 0.003 and 0.001, respectively).
HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs could help in the diagnosis and prognosis of ovarian cancer. |
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| AbstractList | Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease.BACKGROUNDOvarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease.Our study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors.AIMOur study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors.The current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay.SUBJECTS AND METHODSThe current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay.We found significant association of HLA-DP rs3077 AA, HLA-DQ rs3920 GG, ICAM-1 rs1437 CC, and CT genotypes with increased risk of ovarian cancer (OR = 43.5, 6, 25, and 2.6, respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P = 0.003 and 0.001, respectively).RESULTSWe found significant association of HLA-DP rs3077 AA, HLA-DQ rs3920 GG, ICAM-1 rs1437 CC, and CT genotypes with increased risk of ovarian cancer (OR = 43.5, 6, 25, and 2.6, respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P = 0.003 and 0.001, respectively).HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs could help in the diagnosis and prognosis of ovarian cancer.CONCLUSIONHLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs could help in the diagnosis and prognosis of ovarian cancer. Background: Ovarian cancer is considered the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to lack of specific or effective screening and diagnostic methods for identifying early stage disease. Aim: Our study aimed to study the role of HLA-DP, HLA-DQ and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors. Subjects & methods: The current study was conducted on 60 patients with ovarian tumors (benign, borderline and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs 3077, HLA-DQ rs3920 and ICAM-1 rs1437 SNPs was done using 5' nuclease assay. Results: we found significant association of HLA-DP rs 3077 AA, HLA-DQ rs 3920 GG, ICAM-1 rs1437 CC and CT genotypes with increased risk of ovarian cancer (OR=43.5, 6, 25 and 2.6 respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P=0.003 and 0.001, respectively). Conclusion: HLA-DP rs 3077, HLA-DQ rs3920 and ICAM-1 rs1437 SNPs could help in diagnosis and prognosis of ovarian cancer. Ovarian cancer is one of the most lethal gynecological malignancies and the fifth leading cause of cancer deaths among women. The high mortality rate is largely attributed to its diagnosis in advanced stages. Poor prognosis of ovarian cancer is usually due to the lack of specific or effective screening and diagnostic methods for identifying early-stage disease. Our study aimed to study the role of HLA-DP, HLA-DQ, and ICAM-1 SNPs in diagnosis and/or prognosis of ovarian tumors. The current study was conducted on 60 patients with ovarian tumors (benign, borderline, and malignant) and 20 healthy volunteers. Genotyping of HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs was done using 5' nuclease assay. We found significant association of HLA-DP rs3077 AA, HLA-DQ rs3920 GG, ICAM-1 rs1437 CC, and CT genotypes with increased risk of ovarian cancer (OR = 43.5, 6, 25, and 2.6, respectively). In addition, HLA-DQ rs3920 and ICAM-1 rs1437 alleles vary significantly among different types of ovarian cancer (P = 0.003 and 0.001, respectively). HLA-DP rs3077, HLA-DQ rs3920, and ICAM-1 rs1437 SNPs could help in the diagnosis and prognosis of ovarian cancer. |
| Author | El-Etreby, Nour M. Ghazy, Amany A. |
| AuthorAffiliation | 1 Department of Immunology and Allergy, Medical Research Institute, Alexandria University , Alexandria , Egypt 2 Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University , Alexandria , Egypt |
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| Author_xml | – sequence: 1 givenname: Amany A. surname: Ghazy fullname: Ghazy, Amany A. – sequence: 2 givenname: Nour M. surname: El-Etreby fullname: El-Etreby, Nour M. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27252704$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/AOG.0b013e318264f794 10.1002/ijc.22266 10.1016/j.ygyno.2013.02.017 10.1186/s13048-015-0168-9 10.2217/fon.09.126 10.1530/REP-14-0546 10.1054/bjoc.2001.2075 10.1002/ijc.23624 10.1016/j.gene.2013.07.049 10.18632/oncotarget.5358 10.3322/caac.21208 |
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| Keywords | ICAM-1 SNP ovarian cancer HLA-DP HLA-DQ |
| Language | English |
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| References | Al-Alem (B2) 2015; 150 Kirkpatrick (B11) 2013 Baldwin (B4) 2012; 120 Arnold (B9) 2001; 85 Cui (B3) 2015; 8 Ferlay (B12) 2010 Zhou (B7) 2015; 8 Kübler (B8) 2008; 123 Hou (B6) 2015; 6 Cai (B10) 2014; 546 Jiang (B14) 2013; 129 Kübler (B13) 2006; 119 Shih (B5) 2009; 5 Siegel (B1) 2014; 64 23428460 - Gynecol Oncol. 2013 May;129(2):401-5 18561316 - Int J Cancer. 2008 Sep 15;123(6):1350-6 17016821 - Int J Cancer. 2006 Dec 15;119(12):2980-5 20001801 - Future Oncol. 2009 Dec;5(10):1641-57 26064196 - Int J Clin Exp Med. 2015 Mar 15;8(3):3080-8 26077676 - J Ovarian Res. 2015 Jun 16;8:38 22914471 - Obstet Gynecol. 2012 Sep;120(3):612-8 26452130 - Oncotarget. 2015 Nov 3;6(34):35813-29 25918438 - Reproduction. 2015 Aug;150(2):R55-64 23933413 - Gene. 2014 Aug 1;546(1):117-23 11720474 - Br J Cancer. 2001 Nov 2;85(9):1351-8 24399786 - CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 |
| References_xml | – volume: 120 start-page: 612 issue: 3 year: 2012 ident: B4 article-title: Ten-year relative survival for epithelial ovarian cancer publication-title: Obstet Gynecol doi: 10.1097/AOG.0b013e318264f794 – volume: 119 start-page: 2980 issue: 12 year: 2006 ident: B13 article-title: HLA-class II haplotype associations with ovarian cancer publication-title: Int J Cancer doi: 10.1002/ijc.22266 – volume: 129 start-page: 401 issue: 2 year: 2013 ident: B14 article-title: Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2013.02.017 – volume: 8 start-page: 38 issue: 1 year: 2015 ident: B3 article-title: Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis publication-title: J Ovarian Res doi: 10.1186/s13048-015-0168-9 – volume: 5 start-page: 1641 issue: 10 year: 2009 ident: B5 article-title: Pathogenesis of ovarian cancer: clues from selected overexpressed genes publication-title: Future Oncol doi: 10.2217/fon.09.126 – volume-title: GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 [Internet] year: 2010 ident: B12 – volume-title: A Simple Guide to IBM SPSS Statistics for Version 20.0. Student ed year: 2013 ident: B11 – volume: 150 start-page: R55 issue: 2 year: 2015 ident: B2 article-title: Ovarian cancer: involvement of the matrix metalloproteinases publication-title: Reproduction doi: 10.1530/REP-14-0546 – volume: 85 start-page: 1351 issue: 9 year: 2001 ident: B9 article-title: Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas publication-title: Br J Cancer doi: 10.1054/bjoc.2001.2075 – volume: 123 start-page: 1350 issue: 6 year: 2008 ident: B8 article-title: Genetic alterations of HLA-class II in ovarian cancer publication-title: Int J Cancer doi: 10.1002/ijc.23624 – volume: 546 start-page: 117 issue: 1 year: 2014 ident: B10 article-title: Prediction value of intercellular adhesion molecule-1 gene polymorphisms for epithelial ovarian cancer risk, clinical features, and prognosis publication-title: Gene doi: 10.1016/j.gene.2013.07.049 – volume: 8 start-page: 3080 issue: 3 year: 2015 ident: B7 article-title: Prognostic value of cancer stem cell marker CD133 in ovarian cancer: a meta-analysis publication-title: Int J Clin Exp Med – volume: 6 start-page: 35813 issue: 34 year: 2015 ident: B6 article-title: High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis publication-title: Oncotarget doi: 10.18632/oncotarget.5358 – volume: 64 start-page: 9 year: 2014 ident: B1 article-title: Cancer statistics, 2014 publication-title: CA Cancer J Clin doi: 10.3322/caac.21208 – reference: 23933413 - Gene. 2014 Aug 1;546(1):117-23 – reference: 25918438 - Reproduction. 2015 Aug;150(2):R55-64 – reference: 18561316 - Int J Cancer. 2008 Sep 15;123(6):1350-6 – reference: 26064196 - Int J Clin Exp Med. 2015 Mar 15;8(3):3080-8 – reference: 24399786 - CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 – reference: 26452130 - Oncotarget. 2015 Nov 3;6(34):35813-29 – reference: 20001801 - Future Oncol. 2009 Dec;5(10):1641-57 – reference: 23428460 - Gynecol Oncol. 2013 May;129(2):401-5 – reference: 17016821 - Int J Cancer. 2006 Dec 15;119(12):2980-5 – reference: 22914471 - Obstet Gynecol. 2012 Sep;120(3):612-8 – reference: 11720474 - Br J Cancer. 2001 Nov 2;85(9):1351-8 – reference: 26077676 - J Ovarian Res. 2015 Jun 16;8:38 |
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| Title | Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients |
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