A Novel Diagnosis Method Based on Methylation Analysis of SHOX2 and Serum Biomarker for Early Stage Lung Cancer

• Published in: Cancer control Vol. 27; no. 1; p. 1073274820969703
• Main Authors: Huang, Wenhai, Huang, Hao, Zhang, Shuishen, Wang, Xueping, Ouyang, Juan, Lin, Zhichao, Chen, Peisong
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.10.2020; Sage Publications Ltd; SAGE Publishing
• Subjects: Adult; Aged; Aged, 80 and over; Benign; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Carcinoembryonic antigen; Cytokeratin; Diagnosis, Differential; Differential diagnosis; DNA Methylation; Early Detection of Cancer - methods; Electronic medical records; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Homeobox; Homeodomain Proteins - genetics; Humans; Lung - pathology; Lung cancer; Lung diseases; Lung Neoplasms - blood; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Male; Middle Aged; Neoplasm Staging; Original Research Paper; Patients; Phosphopyruvate hydratase; Predictive Value of Tests; Prospective Studies; Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype - genetics; ROC Curve; Tumor markers; Young Adult; lung cancer; diagnosis; decision tree; total methylation; stature homeobox 2

Objectives: Lung cancer (LC) is often accompanied by significant methylation abnormalities. This study aimed to develop a decision tree (DT) accompanied the stature homeobox 2 gene (SHOX2) / prostaglandin E receptor 4 (PTGER4) gene DNA methylation with traditional tumor marker in the differential di...