Aberrant Functional Connectivity Architecture in Alzheimer’s Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 9
• Main Authors: Liu, Yong, Zhang, Xi, An, Ningyu, Xu, Kaibin, Ma, Jianhua, Zhan, Yafeng, Zhang, Zengqiang, Wang, Pan, Yao, Hongxiang, Zhou, Bo, Wang, Luning
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc
• Subjects: Activities of daily living; Aged; Aged, 80 and over; Alzheimer Disease - epidemiology; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer's disease; Automation; Brain; Brain Mapping; Case-Control Studies; Cognition & reasoning; Cognition disorders; Cognitive ability; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; Dementia; Female; Hospitals; Humans; Magnetic Resonance Imaging - methods; Male; Nerve Net - pathology; Nerve Net - physiopathology; Neuropsychology; Physiological aspects; Time series; Beijing China; China

The purpose of our study was to investigate whether the whole-brain functional connectivity pattern exhibits disease severity-related alterations in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Resting-state functional magnetic resonance imaging data were acquired in 2...