Effect of nonylphenol on growth of Neurospora crassa and Candida albicans

Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissio...

Full description

Saved in:
Bibliographic Details
Published inApplied and Environmental Microbiology Vol. 63; no. 4; pp. 1312 - 1317
Main Authors Karley, A J, Powell, S I, Davies, J M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.04.1997
Subjects
Action of physical and chemical agents
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Candida albicans - growth & development
Culture Media
Fundamental and applied biological sciences. Psychology
Glucose
Microbiology
Mycology
Neurospora crassa
Neurospora crassa - drug effects
Neurospora crassa - growth & development
Oxygen
Phenols - toxicity
Candida albicans
Microorganism growth
Yeast
Non ionic surfactant
Fungi
Morphology
Microorganism culture
Ascomycetes
Neurospora crassa
Physiology
Fungi Imperfecti
Inhibition
Respiration
Thallophyta
Online AccessGet full text

Cover

Abstract Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
AbstractList The effects of the nonionic surfactant nonylphenol on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida albicans have been examined. Nonylphenol inhibited respiration and growth of N. crassa, effecting a 10-fold decrease in organism yield at 25 microM. Severe morphological defects were also induced: cell shape was abnormal and apical dominance was lost. Nonylphenol monoethoxylate (the parent compound of nonylphenol) was a less potent growth inhibitor and morphogen. The growth of the yeast form of C. albicans was sensitive to nonylphenol (inducing an order of magnitude decrease in specific growth rate with a 10-fold increase in dose concentration) but not nonylphenol monoethoxylate. Similarly, C. albicans ATP content was reduced and glucose-induced extracellular acidification was inhibited only by nonylphenol. Although estrogens may induce the dimorphic transition of C. albicans, nonylphenol (as an environmental estrogen mimic) failed to trigger germ tube formation under nonpermissive conditions and inhibited it under permissive conditions. The effects of nonylphenol are most readily explained as the result of uncoupling of respiration, which produces multiple physiological effects.The effects of the nonionic surfactant nonylphenol on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida albicans have been examined. Nonylphenol inhibited respiration and growth of N. crassa, effecting a 10-fold decrease in organism yield at 25 microM. Severe morphological defects were also induced: cell shape was abnormal and apical dominance was lost. Nonylphenol monoethoxylate (the parent compound of nonylphenol) was a less potent growth inhibitor and morphogen. The growth of the yeast form of C. albicans was sensitive to nonylphenol (inducing an order of magnitude decrease in specific growth rate with a 10-fold increase in dose concentration) but not nonylphenol monoethoxylate. Similarly, C. albicans ATP content was reduced and glucose-induced extracellular acidification was inhibited only by nonylphenol. Although estrogens may induce the dimorphic transition of C. albicans, nonylphenol (as an environmental estrogen mimic) failed to trigger germ tube formation under nonpermissive conditions and inhibited it under permissive conditions. The effects of nonylphenol are most readily explained as the result of uncoupling of respiration, which produces multiple physiological effects.
Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
The effects of the nonionic surfactant nonylphenol on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida albicans have been examined. Nonylphenol inhibited respiration and growth of N. crassa, effecting a 10-fold decrease in organism yield at 25 mu M. Severe morphological defects were also induced: cell shape was abnormal and apical dominance was lost. Nonylphenol monoethoxylate (the parent compound of nonylphenol) was a less potent growth inhibitor and morphogen. The growth of the yeast form of C. albicans was sensitive to nonylphenol (inducing an order of magnitude decrease in specific growth rate with a 10-fold increase in dose concentration) but not nonylphenol monoethoxylate. Similarly, C. albicans ATP content was reduced and glucose-induced extracellular acidification was inhibited only by nonylphenol. Although estrogens may induce the dimorphic transition of C. albicans, nonylphenol (as an environmental estrogen mimic) failed to trigger germ tube formation under nonpermissive conditions and inhibited it under permissive conditions. The effects of nonylphenol are most readily explained as the result of uncoupling of respiration, which produces multiple physiological effects.
The effects of the nonionic surfactant nonylphenol on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida albicans have been examined. Nonylphenol inhibited respiration and growth of N. crassa, effecting a 10-fold decrease in organism yield at 25 microM. Severe morphological defects were also induced: cell shape was abnormal and apical dominance was lost. Nonylphenol monoethoxylate (the parent compound of nonylphenol) was a less potent growth inhibitor and morphogen. The growth of the yeast form of C. albicans was sensitive to nonylphenol (inducing an order of magnitude decrease in specific growth rate with a 10-fold increase in dose concentration) but not nonylphenol monoethoxylate. Similarly, C. albicans ATP content was reduced and glucose-induced extracellular acidification was inhibited only by nonylphenol. Although estrogens may induce the dimorphic transition of C. albicans, nonylphenol (as an environmental estrogen mimic) failed to trigger germ tube formation under nonpermissive conditions and inhibited it under permissive conditions. The effects of nonylphenol are most readily explained as the result of uncoupling of respiration, which produces multiple physiological effects.
The nonionic surfactant nonylphenol (NP)-a widely used industrial chemical- can be introduced into the environment from industrial discharges or in pesticides. NP effects on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida albicans were studied. NP inhibited N. crassa respiration and growth and induced serious morphological defects. The NP parent compound had less pronounced effects on N. crassa. Yeast growth was sensitive to NP in a dose-dependent manner, but not to the NP parent. NP (but not the NP parent) also inhibited yeast ATP content and glucose-induced extracellular acidification. Although NP mimics some effects of estrogen, it did not trigger germ tube formation in yeast under nonpermissive conditions or inhibit this formation under permissive conditions, as estrogen does. NP appears to act by uncoupling respiration, producing multiple physiological effects.
Author A J Karley
J M Davies
S I Powell
AuthorAffiliation Biology Department, University of York, United Kingdom
AuthorAffiliation_xml – name: Biology Department, University of York, United Kingdom
Author_xml – sequence: 1
  givenname: A J
  surname: Karley
  fullname: Karley, A J
  organization: Biology Department, University of York, United Kingdom
– sequence: 2
  givenname: S I
  surname: Powell
  fullname: Powell, S I
  organization: Biology Department, University of York, United Kingdom
– sequence: 3
  givenname: J M
  surname: Davies
  fullname: Davies, J M
  organization: Biology Department, University of York, United Kingdom
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2651032$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/9097428$$D View this record in MEDLINE/PubMed
BookMark eNqFUstuFDEQtFBQ2AQ-ATFIiNsMfj8OHNAqQKQILrlbPV57x2jWXuxZovw9M8oSCJe9lC1VVXfbXRfoLOXkEXpDcEcI1R_A7zrJOt4RRmg7g-qIMeoZWhFsdCsYk2dohbExLaUcv0AXtf7AGHMs9Tk6N9goTvUKXV-F4N3U5NDMHe7H_eBTHpucmm3Jd9OwEN_8oeS6zwUaV6BWaCBtmvUMcTPfxz46SPUleh5grP7V8bxEt5-vbtdf25vvX67Xn25aJ6ie2kCECFJLiZkXwfcMiNeCKC6EkU7jXm2ccNJQ0NR5oow2nmECIYQePGGX6OND2f2h3_mN82kqMNp9iTso9zZDtE-ZFAe7zb8skZpTMfvfH_0l_zz4OtldrM6PIySfD9UqbQhhRp8UEmGU4UadFnIuhZJLxdf_jv4483EZM__uyEN1MIYCycX6KKNSEMzo3x9w81Zq8cG6OMEU8_LeOFqC7RIRO0fESma5XSKygLJLRGa_-s__p8Np59sH5xC3w10s3kLdPVWz31r_zMc
CODEN AEMIDF
CitedBy_id crossref_primary_10_1016_j_jhazmat_2010_04_034
crossref_primary_10_1111_1758_2229_13032
crossref_primary_10_1021_es010024l
crossref_primary_10_2134_jeq2003_1269
crossref_primary_10_1016_j_ijfoodmicro_2012_12_013
crossref_primary_10_1128_AEM_64_4_1569_1572_1998
crossref_primary_10_1016_j_ecoenv_2019_06_032
crossref_primary_10_1016_j_bej_2023_108935
ContentType Journal Article
Copyright 1997 INIST-CNRS
Copyright_xml – notice: 1997 INIST-CNRS
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7ST
C1K
SOI
7T7
8FD
FR3
M7N
P64
7X8
5PM
DOI 10.1128/aem.63.4.1312-1317.1997
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Environment Abstracts
Environmental Sciences and Pollution Management
Environment Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Technology Research Database
Engineering Research Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Environment Abstracts
Environmental Sciences and Pollution Management
Engineering Research Database
Technology Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

Engineering Research Database

Environment Abstracts
MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Economics
Engineering
Biology
EISSN 1098-5336
EndPage 1317
ExternalDocumentID PMC168425
9097428
2651032
10_1128_aem_63_4_1312_1317_1997
aem_63_4_1312
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-~X
.55
.GJ
0R~
23M
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
6J9
85S
AAGFI
AAYXX
AAZTW
ABOGM
ABPPZ
ACBTR
ACGFO
ACIWK
ACNCT
ACPRK
ADBBV
ADUKH
ADXHL
AENEX
AFFNX
AFRAH
AGCDD
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BKOMP
BTFSW
C1A
CITATION
CS3
D0L
DIK
E.-
E3Z
EBS
EJD
F5P
GX1
H13
HYE
HZ~
H~9
K-O
KQ8
L7B
MVM
NEJ
O9-
OHT
P2P
PQQKQ
RHI
RNS
RPM
RSF
RXW
TAE
TAF
TN5
TR2
TWZ
UHB
VH1
W8F
WH7
WHG
WOQ
X6Y
X7M
XJT
YV5
ZCG
ZGI
ZXP
ZY4
~02
~KM
IQODW
ABTAH
CGR
CUY
CVF
ECM
EIF
NPM
OK1
PKN
RHF
UCJ
Z5M
7ST
C1K
SOI
7T7
8FD
FR3
M7N
P64
7X8
5PM
ID FETCH-LOGICAL-c528t-f155f686603e5feb3a1e851745596c80b7dc5c692a82ce17989e301afffbae13
ISSN 0099-2240
IngestDate Thu Aug 21 18:13:34 EDT 2025
Fri Jul 11 00:04:11 EDT 2025
Fri Jul 11 11:17:44 EDT 2025
Fri Jul 11 08:10:11 EDT 2025
Wed Feb 19 01:16:41 EST 2025
Mon Jul 21 09:14:09 EDT 2025
Thu Apr 24 23:08:42 EDT 2025
Tue Jul 01 04:29:14 EDT 2025
Wed May 18 15:27:04 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Candida albicans
Microorganism growth
Yeast
Non ionic surfactant
Fungi
Morphology
Microorganism culture
Ascomycetes
Neurospora crassa
Physiology
Fungi Imperfecti
Inhibition
Respiration
Thallophyta
Language English
License CC BY 4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c528t-f155f686603e5feb3a1e851745596c80b7dc5c692a82ce17989e301afffbae13
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
OpenAccessLink https://aem.asm.org/content/aem/63/4/1312.full.pdf
PMID 9097428
PQID 14465768
PQPubID 23462
PageCount 6
ParticipantIDs proquest_miscellaneous_14465768
pubmedcentral_primary_oai_pubmedcentral_nih_gov_168425
proquest_miscellaneous_78911398
crossref_citationtrail_10_1128_aem_63_4_1312_1317_1997
crossref_primary_10_1128_aem_63_4_1312_1317_1997
proquest_miscellaneous_15979497
pascalfrancis_primary_2651032
highwire_asm_aem_63_4_1312
pubmed_primary_9097428
ProviderPackageCode CITATION
AAYXX
PublicationCentury 1900
PublicationDate 1997-04-01
PublicationDateYYYYMMDD 1997-04-01
PublicationDate_xml – month: 04
  year: 1997
  text: 1997-04-01
  day: 01
PublicationDecade 1990
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Applied and Environmental Microbiology
PublicationTitleAlternate Appl Environ Microbiol
PublicationYear 1997
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 6221943 - FEBS Lett. 1983 May 30;156(1):11-4
4271185 - J Gen Microbiol. 1973 Sep;78(1):179-92
1491235 - J Exp Biol. 1992 Nov;172:83-92
15091885 - Environ Pollut. 1993;79(3):243-8
15091914 - Environ Pollut. 1993;79(1):59-61
4360924 - J Membr Biol. 1973;14(4):305-38
25343 - J Membr Biol. 1978 Mar 20;39(4):333-67
2942419 - FEBS Lett. 1986 Jul 28;203(2):121-6
7582028 - Microbiology. 1995 Oct;141 ( Pt 10):2685-92
6247154 - Eur J Biochem. 1980 Apr;105(2):419-24
4572714 - J Bacteriol. 1973 Apr;114(1):287-93
2140050 - Biochemistry. 1990 Mar 27;29(12):3091-101
1935846 - Environ Health Perspect. 1991 May;92:167-73
6327882 - J Gen Microbiol. 1984 Mar;130(3):465-71
4267534 - J Bacteriol. 1973 May;114(2):752-66
8336672 - Microbiol Rev. 1993 Jun;57(2):367-82
References_xml – reference: 15091914 - Environ Pollut. 1993;79(1):59-61
– reference: 4271185 - J Gen Microbiol. 1973 Sep;78(1):179-92
– reference: 4572714 - J Bacteriol. 1973 Apr;114(1):287-93
– reference: 6327882 - J Gen Microbiol. 1984 Mar;130(3):465-71
– reference: 2942419 - FEBS Lett. 1986 Jul 28;203(2):121-6
– reference: 8336672 - Microbiol Rev. 1993 Jun;57(2):367-82
– reference: 25343 - J Membr Biol. 1978 Mar 20;39(4):333-67
– reference: 15091885 - Environ Pollut. 1993;79(3):243-8
– reference: 6247154 - Eur J Biochem. 1980 Apr;105(2):419-24
– reference: 7582028 - Microbiology. 1995 Oct;141 ( Pt 10):2685-92
– reference: 6221943 - FEBS Lett. 1983 May 30;156(1):11-4
– reference: 4360924 - J Membr Biol. 1973;14(4):305-38
– reference: 1935846 - Environ Health Perspect. 1991 May;92:167-73
– reference: 2140050 - Biochemistry. 1990 Mar 27;29(12):3091-101
– reference: 4267534 - J Bacteriol. 1973 May;114(2):752-66
– reference: 1491235 - J Exp Biol. 1992 Nov;172:83-92
SSID ssj0004068
Score 1.65888
Snippet Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon...
The effects of the nonionic surfactant nonylphenol on the growth and morphologies of the filamentous fungus Neurospora crassa and the diploid yeast Candida...
The nonionic surfactant nonylphenol (NP)-a widely used industrial chemical- can be introduced into the environment from industrial discharges or in pesticides....
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1312
SubjectTerms Action of physical and chemical agents
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Candida albicans - growth & development
Culture Media
Fundamental and applied biological sciences. Psychology
Glucose
Microbiology
Mycology
Neurospora crassa
Neurospora crassa - drug effects
Neurospora crassa - growth & development
Oxygen
Phenols - toxicity
Title Effect of nonylphenol on growth of Neurospora crassa and Candida albicans
URI http://aem.asm.org/content/63/4/1312.abstract
https://www.ncbi.nlm.nih.gov/pubmed/9097428
https://www.proquest.com/docview/14465768
https://www.proquest.com/docview/15979497
https://www.proquest.com/docview/78911398
https://pubmed.ncbi.nlm.nih.gov/PMC168425
Volume 63
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagqKIcECxUbEshB25VliROHPtYVaC2CITEIvUWObZDV-ruVk16KL-eGdt5QZfXxVrFjmNlJrMz4_k-E_JGq0hwLlRoTFmGqdIylEqrsMxprmPGVSYxNfDxEzv5mp6dZ-ftEfceXdKUM_X9TlzJ_0gVroFcESX7D5LtJoUL8BvkCy1IGNq_krGnHsZaDCwwx3Kt9SWm_79BcN1c2GyA5atE9qlDdQ2OsoVgHR4jmEVLLE5GM1gPXdTWL8VxAxgcokwWPWtTZ6hxt_7WWZgu5fx53dZaf-mzslg972zSmU_Bao--ywc1Kt6AChGiFzA0oN5CLYbZAWsNY-pKpH810wlCD6RZzhidpTMcF0KTI3YyH94B7_tqaaUnIoh8PI58TJDte-6TBwmECjasPv3QY2MjxlsmUly4r_GDFbzd8Pwdsu2nHPsqLX80ls_KGr6gyh19clds8nOJ7cBnmT8hj32wERw5zXlK7pnVhGy740dvJ-Rhi0qvJ-TRgJjyGTl1mhWsq2CgWcF6FTjNwo5eswKnWQFoTOA1K2g16zmZv383Pz4J_aEbocoS3oQVOJgV44xF1GSVKamMDUc6cwg9meJRmWuVKSYSyRNlkO5OGPiTkFVVldLEdJdswcLMCxJQxmSiFPi8mqYa85UYnlImRJarWOspYe3bLZQnpMdzUS4LG5gmvAABFYwWaYECwiYvUEBTEnU3XjlOlj_fsteKr5D1cjxsSg5GAu0mTZjlm5yS162ACzC-uKMmV2Z9UxeWbhAC9t-MgIBdpLiATSNyDv4GFTDHrlOZ7vFeC-E9jXSp60dm-HHPanFhGeJju7u-t2nGfbLTf9wvyVZzfWMOwLduylf24_kBqA_Kug
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+nonylphenol+on+growth+of+Neurospora+crassa+and+Candida+albicans&rft.jtitle=Applied+and+environmental+microbiology&rft.au=Karley%2C+A+J&rft.au=Powell%2C+S+I&rft.au=Davies%2C+J+M&rft.date=1997-04-01&rft.issn=0099-2240&rft.volume=63&rft.issue=4&rft.spage=1312&rft_id=info:doi/10.1128%2Faem.63.4.1312-1317.1997&rft_id=info%3Apmid%2F9097428&rft.externalDocID=9097428
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0099-2240&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0099-2240&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0099-2240&client=summon