Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

• Published in: Journal of dental research Vol. 94; no. 3_suppl; pp. 59S - 69S
• Main Authors: Kalea, A.Z., Hoteit, R., Suvan, J., Lovering, R.C., Palmen, J., Cooper, J.A., Khodiyar, V.K., Harrington, Z., Humphries, S.E., D’Aiuto, F.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.03.2015; SAGE PUBLICATIONS, INC
• Subjects: Adult; Angiogenesis; Bioinformatics; Biomedical research; Biopsy; Body Weight; Cell differentiation; Cell Differentiation - genetics; Cell Movement - genetics; Clinical Investigations; Data analysis; DNA-Binding Proteins - genetics; Female; Funding; GATA2 Transcription Factor - analysis; Gene expression; Gene Expression Profiling; Genomics; Gingiva; Gingiva - metabolism; Gum disease; Homeodomain Proteins - analysis; Humans; Inflammation; Male; Medical research; MicroRNAs; MicroRNAs - analysis; miRNA; Neovascularization, Physiologic - genetics; Obesity; Obesity - genetics; Patients; Periodontitis; Periodontitis - genetics; Polymerase chain reaction; Repressor Proteins - analysis; Research centers; Reverse Transcriptase Polymerase Chain Reaction - methods; Reverse transcription; Studies; Teeth; Therapeutic applications; Transcription Factors - analysis; University colleges; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2 - analysis; Wound healing; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1; Zinc Fingers - genetics; United Kingdom > UK; United States > US; epithelial; wound healing; angiogenesis; obesity; periodontal disease; microRNA-200b

Increased local immune and inflammatory responses in obese individuals with periodontitis may explain the aggressive clinical presentation and altered treatment response when compared to that of normal weight subjects. Our goal was to identify any differences in microRNA (miRNA) expression profiles...