The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism

Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are beli...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in endocrinology (Lausanne) Vol. 5; p. 152
Main Authors Tomita, Tsutomu, Hosoda, Kiminori, Fujikura, Junji, Inagaki, Nobuya, Nakao, Kazuwa
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2014
Subjects
Endocrinology
FFAR1
GPR40
insulin secretion
LCFA
pancreatic beta cells
LCFA
pancreatic beta cells
FFAR1
GPR40
insulin secretion
Online AccessGet full text

Cover

Abstract Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target.
AbstractList Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion by pancreatic beta cells, where fatty acid-derived metabolites, such as long-chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target.
Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells, where fatty acid-derived metabolites, such as long chain fatty acyl-CoAs, are believed to act as crucial effectors. Recently, G-protein-coupled receptor 40 (GPR40), a receptor for long-chain fatty acids, was reported to be highly expressed in pancreatic beta cells and involved in the regulation of insulin secretion. Hence, GPR40 is considered to be a potential therapeutic target for the treatment of diabetes. In this review, we summarize the identification and gene expression patterns of GPR40 and its role in glucose metabolism. We also discuss the potential application of GPR40 as a therapeutic target.
Author Hosoda, Kiminori
Fujikura, Junji
Tomita, Tsutomu
Inagaki, Nobuya
Nakao, Kazuwa
AuthorAffiliation 2 Medical Innovation Center, Kyoto University Graduate School of Medicine , Kyoto , Japan
1 Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
AuthorAffiliation_xml – name: 2 Medical Innovation Center, Kyoto University Graduate School of Medicine , Kyoto , Japan
– name: 1 Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
Author_xml – sequence: 1
  givenname: Tsutomu
  surname: Tomita
  fullname: Tomita, Tsutomu
  organization: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
– sequence: 2
  givenname: Kiminori
  surname: Hosoda
  fullname: Hosoda, Kiminori
  organization: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
– sequence: 3
  givenname: Junji
  surname: Fujikura
  fullname: Fujikura, Junji
  organization: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
– sequence: 4
  givenname: Nobuya
  surname: Inagaki
  fullname: Inagaki, Nobuya
  organization: Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine , Kyoto , Japan
– sequence: 5
  givenname: Kazuwa
  surname: Nakao
  fullname: Nakao, Kazuwa
  organization: Medical Innovation Center, Kyoto University Graduate School of Medicine , Kyoto , Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25309513$$D View this record in MEDLINE/PubMed
BookMark eNpVkc9rHCEUgKWkNGmae0_FYy-z9anj6KUQlmYb2NI0pGdx9M3uhFnd6kwh_30nu2lI5IHyfnxP-N6Tk5giEvIR2EIIbb50GENacAZywRjU_A05A6VkxYXhJy_ep-SilHs2H8nAGP2OnPJaMFODOCO_7rZIV9VNTiP2sVqmaT9goOsUN9Vy6_pIr9w4PtBL3wd6ix73Y8p0dXMrGXUx0NUw-VSQ_sDRtWnoy-4Dedu5oeDF031Ofl99u1t-r9Y_V9fLy3Xla67HCnHeH0zTaG6YMNh6obpaCwGGsdCp4KAGH1rgAQ3KlmvBpBGdaWGuoBHn5PrIDcnd233udy4_2OR6e0ikvLEuj70f0GrZSaNBGahnhlYmdHVAwRvOFTZdM7O-Hln7qd1h8BjH7IZX0NeV2G_tJv21EhollZwBn58AOf2ZsIx21xePw-AipqlYUDBHwzjMrezY6nMqJWP3vAaYfRRrD2Lto1h7EDuPfHr5veeB_xrFP6UDnsI
CitedBy_id crossref_primary_10_1080_13543776_2020_1698546
crossref_primary_10_1155_2022_8744964
crossref_primary_10_1016_j_bmc_2020_115574
crossref_primary_10_1146_annurev_pharmtox_030220_121042
crossref_primary_10_1186_s12933_014_0159_y
crossref_primary_10_3390_cells10123347
crossref_primary_10_1007_s00213_021_05837_4
crossref_primary_10_3390_antiox10020197
crossref_primary_10_1016_j_bmc_2017_03_001
crossref_primary_10_1016_j_bmc_2016_08_068
crossref_primary_10_1080_00498254_2020_1864510
crossref_primary_10_1155_2018_2503950
crossref_primary_10_1016_j_pneurobio_2017_01_004
crossref_primary_10_1089_ars_2021_0113
crossref_primary_10_1111_jnc_15314
crossref_primary_10_1002_med_21441
crossref_primary_10_1016_j_ejmech_2017_07_001
crossref_primary_10_1021_acs_jmedchem_5b01962
crossref_primary_10_3389_fimmu_2017_01889
crossref_primary_10_3390_nu13051513
crossref_primary_10_1038_cddis_2015_114
crossref_primary_10_1016_j_imr_2020_100450
crossref_primary_10_3390_molecules25051102
crossref_primary_10_1016_j_ejmech_2019_06_087
crossref_primary_10_1016_j_ygyno_2016_02_026
crossref_primary_10_3389_fendo_2023_1206063
crossref_primary_10_3389_fnut_2023_1098715
crossref_primary_10_1016_j_aninu_2023_04_003
crossref_primary_10_1038_s41423_019_0309_y
crossref_primary_10_3389_fendo_2015_00178
crossref_primary_10_1146_annurev_nutr_071714_034410
crossref_primary_10_1080_13543776_2023_2272649
crossref_primary_10_2174_1389557520666201023141326
crossref_primary_10_1021_acs_biochem_6b00079
Cites_doi 10.1073/pnas.1114350109
10.1016/j.cmet.2005.03.007
10.1016/j.bbrc.2007.10.142
10.1007/s00125-008-1202-x
10.1038/nature01478
10.1016/j.bbrc.2005.10.161
10.2337/db08-0307
10.1074/jbc.M211495200
10.1016/S0014-5793(02)02775-8
10.2337/db08-1233
10.2337/db09-0362
10.1053/j.gastro.2010.10.012
10.1074/jbc.M702115200
10.2337/db06-1532
10.1172/JCI1813
10.1021/ml1000855
10.2337/diabetes.47.10.1613
10.1124/jpet.111.183772
10.1016/j.mce.2013.07.025
10.1172/JCI118727
10.2337/dc12-0872
10.1016/j.metabol.2012.06.010
10.2337/db08-0596
10.1007/s00125-006-0193-8
10.1124/jpet.111.187708
10.1016/S0140-6736(11)61879-5
10.2337/db08-0553
ContentType Journal Article
Copyright Copyright © 2014 Tomita, Hosoda, Fujikura, Inagaki and Nakao. 2014
Copyright_xml – notice: Copyright © 2014 Tomita, Hosoda, Fujikura, Inagaki and Nakao. 2014
DBID NPM
AAYXX
CITATION
7X8
5PM
DOA
DOI 10.3389/fendo.2014.00152
DatabaseName PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1664-2392
EndPage 152
ExternalDocumentID oai_doaj_org_article_84f49816915049869df5de327226e7f7
10_3389_fendo_2014_00152
25309513
Genre Journal Article
Review
GroupedDBID 53G
5VS
9T4
AAFWJ
AAKDD
ACGFO
ACGFS
ACXDI
ADBBV
ADRAZ
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
DIK
EMOBN
GROUPED_DOAJ
GX1
HYE
IAO
IEA
IHR
IHW
IPNFZ
KQ8
M48
M~E
NPM
OK1
PGMZT
RIG
RPM
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-c528t-ee513d977829039ebc36f58331900df6da151cdb12de9e4b2830493f9b1a15e93
IEDL.DBID RPM
ISSN 1664-2392
IngestDate Tue Oct 22 15:06:29 EDT 2024
Tue Sep 17 21:24:27 EDT 2024
Fri Aug 16 20:42:42 EDT 2024
Fri Aug 23 02:41:52 EDT 2024
Sat Sep 28 07:56:47 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords LCFA
pancreatic beta cells
FFAR1
GPR40
insulin secretion
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c528t-ee513d977829039ebc36f58331900df6da151cdb12de9e4b2830493f9b1a15e93
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Ikuo Kimura, Tokyo University of Agriculture and Technology, Japan
This article was submitted to Diabetes, a section of the journal Frontiers in Endocrinology.
Reviewed by: Carol Huang, University of Calgary, Canada; Kay Waud, Jones Institute for Reproductive Medicine, USA
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176464/
PMID 25309513
PQID 1611617021
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_84f49816915049869df5de327226e7f7
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4176464
proquest_miscellaneous_1611617021
crossref_primary_10_3389_fendo_2014_00152
pubmed_primary_25309513
PublicationCentury 2000
PublicationDate 2014-01-01
PublicationDateYYYYMMDD 2014-01-01
PublicationDate_xml – month: 01
  year: 2014
  text: 2014-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle Frontiers in endocrinology (Lausanne)
PublicationTitleAlternate Front Endocrinol (Lausanne)
PublicationYear 2014
Publisher Frontiers Media S.A
Publisher_xml – name: Frontiers Media S.A
References 22308370 - Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2376-81
9753300 - Diabetes. 1998 Oct;47(10):1613-8
12496284 - J Biol Chem. 2003 Mar 28;278(13):11303-11
16289108 - Biochem Biophys Res Commun. 2005 Dec 30;338(4):1788-90
23086138 - Diabetes Care. 2013 Feb;36(2):245-50
18559658 - Diabetes. 2008 Sep;57(9):2432-7
18678612 - Diabetes. 2008 Nov;57(11):2999-3006
12629551 - Nature. 2003 Mar 13;422(6928):173-6
21752941 - J Pharmacol Exp Ther. 2011 Oct;339(1):228-37
16054069 - Cell Metab. 2005 Apr;1(4):245-58
24900210 - ACS Med Chem Lett. 2010 Jun 18;1(6):290-4
19720802 - Diabetes. 2009 Nov;58(11):2607-15
17395749 - Diabetes. 2007 Apr;56(4):1087-94
19082577 - Diabetologia. 2009 Feb;52(2):289-98
17525159 - J Biol Chem. 2007 Aug 10;282(32):23561-71
17980148 - Biochem Biophys Res Commun. 2008 Jan 4;365(1):22-8
19401434 - Diabetes. 2009 May;58(5):1067-76
22883930 - Metabolism. 2013 Jan;62(1):70-8
8675683 - J Clin Invest. 1996 Jun 15;97(12):2728-35
12044878 - FEBS Lett. 2002 Jun 5;520(1-3):97-101
18519800 - Diabetes. 2008 Sep;57(9):2280-7
22374408 - Lancet. 2012 Apr 14;379(9824):1403-11
23911664 - Mol Cell Endocrinol. 2013 Dec 5;381(1-2):150-9
22106100 - J Pharmacol Exp Ther. 2012 Feb;340(2):483-9
16525841 - Diabetologia. 2006 May;49(5):962-8
9616208 - J Clin Invest. 1998 Jun 1;101(11):2370-6
20955703 - Gastroenterology. 2011 Mar;140(3):903-12
Briscoe (B6) 2003; 278
Parker (B21) 2009; 52
Yashiro (B25) 2012; 340
Lan (B16) 2008; 57
Liou (B22) 2011; 140
Itoh (B5) 2003; 422
Alquier (B18) 2009; 58
Stein (B1) 1996; 97
Latour (B17) 2007; 56
Edfalk (B20) 2008; 57
Burant (B26) 2012; 379
Tomita (B9) 2005; 338
Steneberg (B14) 2005; 1
Tsujihata (B24) 2011; 339
Bartoov-Shifman (B13) 2007; 282
Kebede (B12) 2012; 109
Meidute Abaraviciene (B8) 2013; 381
Dobbins (B2) 1998; 101
Negoro (B23) 2010; 1
Takeda (B4) 2002; 520
Kaku (B27) 2013; 36
Hirasawa (B7) 2008; 365
Tomita (B10) 2006; 49
Nagasumi (B19) 2009; 58
Dobbins (B3) 1998; 47
Kebede (B15) 2008; 57
Odori (B11) 2013; 62
References_xml – volume: 109
  start-page: 2376
  year: 2012
  ident: B12
  article-title: Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1114350109
  contributor:
    fullname: Kebede
– volume: 1
  start-page: 245
  year: 2005
  ident: B14
  article-title: The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2005.03.007
  contributor:
    fullname: Steneberg
– volume: 365
  start-page: 22
  year: 2008
  ident: B7
  article-title: Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1)
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2007.10.142
  contributor:
    fullname: Hirasawa
– volume: 52
  start-page: 289
  year: 2009
  ident: B21
  article-title: Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
  publication-title: Diabetologia
  doi: 10.1007/s00125-008-1202-x
  contributor:
    fullname: Parker
– volume: 422
  start-page: 173
  year: 2003
  ident: B5
  article-title: Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
  publication-title: Nature
  doi: 10.1038/nature01478
  contributor:
    fullname: Itoh
– volume: 338
  start-page: 1788
  year: 2005
  ident: B9
  article-title: GPR40 gene expression in human pancreas and insulinoma
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2005.10.161
  contributor:
    fullname: Tomita
– volume: 57
  start-page: 2280
  year: 2008
  ident: B20
  article-title: Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
  publication-title: Diabetes
  doi: 10.2337/db08-0307
  contributor:
    fullname: Edfalk
– volume: 278
  start-page: 11303
  year: 2003
  ident: B6
  article-title: The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M211495200
  contributor:
    fullname: Briscoe
– volume: 520
  start-page: 97
  year: 2002
  ident: B4
  article-title: Identification of G protein-coupled receptor genes from the human genome sequence
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(02)02775-8
  contributor:
    fullname: Takeda
– volume: 58
  start-page: 1067
  year: 2009
  ident: B19
  article-title: Overexpression of gpr40 in pancreatic β-cells augments glucose stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
  publication-title: Diabetes
  doi: 10.2337/db08-1233
  contributor:
    fullname: Nagasumi
– volume: 58
  start-page: 2607
  year: 2009
  ident: B18
  article-title: Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
  publication-title: Diabetes
  doi: 10.2337/db09-0362
  contributor:
    fullname: Alquier
– volume: 140
  start-page: 903
  year: 2011
  ident: B22
  article-title: The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.10.012
  contributor:
    fullname: Liou
– volume: 282
  start-page: 23561
  year: 2007
  ident: B13
  article-title: Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M702115200
  contributor:
    fullname: Bartoov-Shifman
– volume: 56
  start-page: 1087
  year: 2007
  ident: B17
  article-title: GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
  publication-title: Diabetes
  doi: 10.2337/db06-1532
  contributor:
    fullname: Latour
– volume: 101
  start-page: 2370
  year: 1998
  ident: B2
  article-title: A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion
  publication-title: J Clin Invest
  doi: 10.1172/JCI1813
  contributor:
    fullname: Dobbins
– volume: 1
  start-page: 290
  year: 2010
  ident: B23
  article-title: Discovery of TAK-875: a potent, selective, and orally bioavailable GPR40 agonist
  publication-title: ACS Med Chem Lett
  doi: 10.1021/ml1000855
  contributor:
    fullname: Negoro
– volume: 47
  start-page: 1613
  year: 1998
  ident: B3
  article-title: Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans
  publication-title: Diabetes
  doi: 10.2337/diabetes.47.10.1613
  contributor:
    fullname: Dobbins
– volume: 339
  start-page: 228
  year: 2011
  ident: B24
  article-title: TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.111.183772
  contributor:
    fullname: Tsujihata
– volume: 381
  start-page: 150
  year: 2013
  ident: B8
  article-title: GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2013.07.025
  contributor:
    fullname: Meidute Abaraviciene
– volume: 97
  start-page: 2728
  year: 1996
  ident: B1
  article-title: Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
  publication-title: J Clin Invest
  doi: 10.1172/JCI118727
  contributor:
    fullname: Stein
– volume: 36
  start-page: 245
  year: 2013
  ident: B27
  article-title: Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes
  publication-title: Diabetes Care
  doi: 10.2337/dc12-0872
  contributor:
    fullname: Kaku
– volume: 62
  start-page: 70
  year: 2013
  ident: B11
  article-title: GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2012.06.010
  contributor:
    fullname: Odori
– volume: 57
  start-page: 2999
  year: 2008
  ident: B16
  article-title: Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease
  publication-title: Diabetes
  doi: 10.2337/db08-0596
  contributor:
    fullname: Lan
– volume: 49
  start-page: 962
  year: 2006
  ident: B10
  article-title: Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion
  publication-title: Diabetologia
  doi: 10.1007/s00125-006-0193-8
  contributor:
    fullname: Tomita
– volume: 340
  start-page: 483
  year: 2012
  ident: B25
  article-title: The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.111.187708
  contributor:
    fullname: Yashiro
– volume: 379
  start-page: 1403
  year: 2012
  ident: B26
  article-title: TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(11)61879-5
  contributor:
    fullname: Burant
– volume: 57
  start-page: 2432
  year: 2008
  ident: B15
  article-title: The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
  publication-title: Diabetes
  doi: 10.2337/db08-0553
  contributor:
    fullname: Kebede
SSID ssj0000401998
Score 2.2134438
SecondaryResourceType review_article
Snippet Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 152
SubjectTerms Endocrinology
FFAR1
GPR40
insulin secretion
LCFA
pancreatic beta cells
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na9wwEBUlh9JLadIvNx8o0EsPIrb1YeuYhCahsKEtDeQmZGnULGy0S-M95N9nJHvDbijkkqtl8DBP1rznkZ4J-ap4U8ugPOPONUxwVTJbSsugw2qcDMddduefXKqLK_HjWl6v_eor7Qkb7IGHxB21IgjdJksXiWS2VdoH6YHXDfIGaMJwjrzUa2Iqr8EoG1BIDH1JVGH6KED06bBfldyyK1lv1KFs1_8_jvl0q-Ra7Tl7R96OpJEeD8Fuk1cQd8jrydgWf09-Idj0nGXPhWlkbr5czMDT2Tz-Ze4GtT8Ntu_vqXVTT3GJgwUqbXr-87coqY2ejvvW6S30OCdm07vbD-Tq7Puf0ws2_iuBOVm3PQOQFfdI5lJjlGvoHFchnajCgl96BMNiaXe-q2oPGkSXfL-E5kF3FY6A5h_JVpxH-Eyo0Fbgm28tkkERpNJSImkquUAtWAXfFuTbKnNmMVhiGJQSKcsmZ9mkLJuc5YKcpNQ-3pfMrPMFhNiMEJvnIC7I4QoYg5M_dTRshPnyzmCESZ8hTynIpwGox0fVkif6yAvSbEC4EcvmSJzeZINtUTVKKPHlJYLfJW9SOoavNntkq_-3hH3kMX13kKfsA_6A7Hw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1Lj9MwELZgkRAXxJvwkpG4cDAk8SPxAaGlol0hihZEpb1FTmzvRipOaVOJ_ffMOOlCUbnGkWPPjD3fZDyfCXmleJFLryzjTVMwwVXKTCoNczV4YyQcbyI7__yLOlmIT2fy7E959CjAzcHQDu-TWqyXb379vHwPC_4dRpzgb996FyzW8WVIhA3-6Dq5kWMhEB7kG8F-3JchlNDxctxMKcFyQAZD3vJgJ8gSLDkCEL7nsiKz_yE4-u-pyr_c1PQOuT3iS3o8GMRdcs2Fe-TmfMyg3ydfwS7ojJ0iPUMb2KTbrpbO0s9dOGeTC9MGOjV9f0mPm9ZSwJRuBUE5nZ1-Eyk1wdLZcMSdzl0P5rNsNz8ekMX04_fJCRuvVWCNzMueOQdzsoD7MIfKtasbrjwWXwE2SC3ozQAKaGyd5dZpJ2qkCBOae11n0OI0f0iOQhfcY0KFNgI2CWMANwovlZYS8FXKBYSNmbdlQl7vJFetBvaMCqIOFHgVBV6hwKso8IR8QNFevYe81_FBtz6vxmVUlcILXSLBj4QxlUpbL63jeQEo0hW-SMjLnWIqWCeY_DDBddtNBSPEUA4gTUIeDYq6-tRO0Qkp9lS4N5b9ltBeRC5ukRVKKPHkv30-JbdwjsNfm2fkqF9v3XPAMX39Iprnb3pV6Y0
  priority: 102
  providerName: Scholars Portal
Title The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism
URI https://www.ncbi.nlm.nih.gov/pubmed/25309513
https://search.proquest.com/docview/1611617021
https://pubmed.ncbi.nlm.nih.gov/PMC4176464
https://doaj.org/article/84f49816915049869df5de327226e7f7
Volume 5
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV09b9swECWSDEWXot9V2gYM0KUDY8n8kDimRu0giAq3aABvBEVSiQCbMhJ56L_vkZKCuOiUhYMoQdTdUfeeeHxC6Iug-ZTXwhJqTE4YFSnRKdfEVZCNg-C4ier85Q9xcc0uV3x1gPi4FyYW7ZuqOfPrzZlvbmNt5XZjJmOd2GRZzliWCybY5BAdQoA-oujx9QuMAThEvyQJBExOaudt2OeXBaFsyFdBAJjTgC3oXjaKov3_Q5r_Fkw-ykDzl-jFAB3xeT_EV-jA-dfoWTksjr9BP8HleEGWQXmh8WTW7rZrZ_FV62_I7FY3Hs911_3B56axGOCi2wLfxovlL5Zi7S1e9NXruHQdRMa6ud-8Rdfz779nF2T4YwIxfFp0xDl4JguQLiyPUukqQ0Ud9lVB2k8tuERDgje2yqbWSceqoP7FJK1llUGPk_QdOvKtdx8QZlIzmP9aAyRkNReSc4BOKWXACLPaFgn6OlpObXthDAWEIhhcRYOrYHAVDZ6gb8G0D-cFSet4oL27UYNjVcFqJoug3cNhTIWQtubW0WkOANHldZ6g09ExCqZAWNfQ3rW7ewUjDCwN0EqC3veOerjV6OgE5Xsu3BvLfg9EXZTZHqLs-MlXfkTPgw36Dzaf0FF3t3OfAcJ01Umk_tAuVhm0JStOYhD_BXj28AU
link.rule.ids 230,315,730,783,787,867,888,2109,24331,27937,27938,53805,53807
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLbGkIALvwfhp5G4cHCb1HYSH0dFW6CdCtrQbpZjO1tE61RbeoC_nmcnmdaJC1zjRHnx95z3vbznLwi9T2k24mVqCNU6I4ymMVExV8QWEI294LgO6vyLo3R2wr6c8tM9xPu9MKFpXxfVwK3WA1edh97KzVoP-z6x4XIxZkmWspQNb6HbsF5jfi1JDy9gyBkgi2iLkpCCiWFpnfE7_RIvlQ0Ry0sAc-rZBd2JR0G2_29c82bL5LUYNHmAfvTWt60nPwfbphjo3zeEHf_58R6i-x0rxYft8CO0Z91jdGfR1d2foG_gTXhKll7UoXJkXG83K2vwvHZnZHyuKocnqml-4UNdGQxM1G4glcfT5XcWY-UMnraN8XhhG3C6VXW5fopOJp-OxzPS_YyBaD7KG2ItTJYBtugrr1TYQtO09Fu2gFHEBtBWwB20KZKRscKywguLMUFLUSQwYgU9QPuudvY5wkwoBq8WpYBtspKngnNgZTFlkGwmpckj9KGHRG5azQ0JuYpHUgYkpUdSBiQj9NFjdnWeV8sOB-qLM9lNqsxZyUTuZYE42JSnwpTcWDrKgHvarMwi9K5HXMLq8iUT5Wy9vZRgoU8AgQhF6FnrAVe36j0oQtmOb-zYsjsCiAcF7w7hF_995Vt0d3a8mMv556OvL9E9Px_td6FXaL-52NrXwJSa4k1YF38AvV8PSw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLagSBUX9iWsRuLCwTPJ2M5yLAMzBTrVgKhUcbEcL23EjBO1mQP8ep6dpJqpOPUaO4rt79n-Xt7zZ4TepzSbcJtqQpXKCKNpTGTMJTEl7MZecFwFdf7FcXp4wr6e8tOtq75C0r4qq5FbrUeuOg-5lc1ajYc8sfFyMWVJlrKUjRttx7fRHe5F07cc9bAIg98AnkQXmAQ3rBhb47Q_7Zd4uWzYtbwMMKeeYdCdPSlI9_-Pb15Pm9zah2b30a-hB136ye_Rpi1H6u81cccbdfEButezU3zQVXmIbhn3CO0v-vj7Y_QdrArPydKLO1SOTOtNszIaH9XujEzPZeXwTLbtH3ygKo2BkZoGXHo8X_5gMZZO43mXII8XpgXjW1WX6yfoZPb55_SQ9JcyEMUneUuMgQHTwBp9BJYWplQ0tf7oFjCLWAPqEjiE0mUy0aYwrPQCY6ygtigTKDEFfYr2XO3Mc4RZIRksMVIC62SWpwXnwM5iysDpTKzOI_RhgEU0nfaGAJ_FoykCmsKjKQKaEfrocbuq51Wzw4P64kz0AytyZlmRe3kgDm3K00Jbrg2dZMBBTWazCL0bUBcwy3zoRDpTby4FtNA7gkCIIvSss4KrTw1WFKFsxz522rJbAqgHJe8e5Rc3fvMt2l9-momjL8ffXqK7fji630Ov0F57sTGvgTC15ZswNf4BXlwRyw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+G-Protein-Coupled+Long-Chain+Fatty+Acid+Receptor+GPR40+and+Glucose+Metabolism&rft.jtitle=Frontiers+in+endocrinology+%28Lausanne%29&rft.au=Tomita%2C+Tsutomu&rft.au=Hosoda%2C+Kiminori&rft.au=Fujikura%2C+Junji&rft.au=Inagaki%2C+Nobuya&rft.date=2014-01-01&rft.issn=1664-2392&rft.eissn=1664-2392&rft.volume=5&rft.spage=152&rft_id=info:doi/10.3389%2Ffendo.2014.00152&rft_id=info%3Apmid%2F25309513&rft.externalDocID=25309513
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2392&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2392&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2392&client=summon