Endoplasmic Reticulum Unfolded Protein Response, Aging and Exercise: An Update

• Published in: Frontiers in physiology Vol. 9; p. 1744
• Main Authors: Estébanez, Brisamar, de Paz, José A., Cuevas, María J., González-Gallego, Javier
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.12.2018
• Subjects: aging; elderly; endoplasmic reticulum stress; exercise; Physiology; training; unfolded protein response; unfolded protein response; exercise; training; aging; elderly; endoplasmic reticulum stress

The endoplasmic reticulum (ER) is a dynamic and multifunctional organelle responsible for protein biosynthesis, folding, assembly and modifications. Loss of protein folding regulation, which leads to unfolded or misfolded proteins accumulation inside the ER lumen, drives ER stress (ERS) and unfolded...