IgY antibodies in human nutrition for disease prevention
Oral administration of preformed specific antibodies is an attractive approach against infections of the digestive system in humans and animals in times of increasing antibiotic resistances. Previous studies showed a positive effect of egg yolk IgY antibodies on bacterial intoxications in animals an...
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| Published in | Nutrition journal Vol. 14; no. 1; p. 109 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
20.10.2015
BioMed Central |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Oral administration of preformed specific antibodies is an attractive approach against infections of the digestive system in humans and animals in times of increasing antibiotic resistances. Previous studies showed a positive effect of egg yolk IgY antibodies on bacterial intoxications in animals and humans. Immunization of chickens with specific antigens offers the possibility to create various forms of antibodies. Research shows that orally applied IgY's isolated from egg yolks can passively cure or prevent diseases of the digestive system. The use of these alternative therapeutic drugs provides further advantages: (1) The production of IgY's is a non-invasive alternative to current methods; (2) The keeping of chickens is inexpensive; (3) The animals are easy to handle; (4) It avoids repetitive bleeding of laboratory animals; (5) It is also very cost effective regarding the high IgY concentration within the egg yolk. Novel targets of these antigen specific antibodies are Helicobacter pylori and also molecules involved in signaling pathways in gastric cancer. Furthermore, also dental caries causing bacteria like Streptococcus mutans or opportunistic Pseudomonas aeruginosa in cystic fibrosis patients are possible targets. Therefore, IgY's included in food for human consumption may be able to prevent or cure human diseases. |
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| AbstractList | Oral administration of preformed specific antibodies is an attractive approach against infections of the digestive system in humans and animals in times of increasing antibiotic resistances. Previous studies showed a positive effect of egg yolk IgY antibodies on bacterial intoxications in animals and humans. Immunization of chickens with specific antigens offers the possibility to create various forms of antibodies. Research shows that orally applied IgY's isolated from egg yolks can passively cure or prevent diseases of the digestive system. The use of these alternative therapeutic drugs provides further advantages: (1) The production of IgY's is a non-invasive alternative to current methods; (2) The keeping of chickens is inexpensive; (3) The animals are easy to handle; (4) It avoids repetitive bleeding of laboratory animals; (5) It is also very cost effective regarding the high IgY concentration within the egg yolk. Novel targets of these antigen specific antibodies are Helicobacter pylori and also molecules involved in signaling pathways in gastric cancer. Furthermore, also dental caries causing bacteria like Streptococcus mutans or opportunistic Pseudomonas aeruginosa in cystic fibrosis patients are possible targets. Therefore, IgY's included in food for human consumption may be able to prevent or cure human diseases. Oral administration of preformed specific antibodies is an attractive approach against infections of the digestive system in humans and animals in times of increasing antibiotic resistances. Previous studies showed a positive effect of egg yolk IgY antibodies on bacterial intoxications in animals and humans. Immunization of chickens with specific antigens offers the possibility to create various forms of antibodies. Research shows that orally applied IgY's isolated from egg yolks can passively cure or prevent diseases of the digestive system. The use of these alternative therapeutic drugs provides further advantages: (1) The production of IgY's is a non-invasive alternative to current methods; (2) The keeping of chickens is inexpensive; (3) The animals are easy to handle; (4) It avoids repetitive bleeding of laboratory animals; (5) It is also very cost effective regarding the high IgY concentration within the egg yolk. Novel targets of these antigen specific antibodies are Helicobacter pylori and also molecules involved in signaling pathways in gastric cancer. Furthermore, also dental caries causing bacteria like Streptococcus mutans or opportunistic Pseudomonas aeruginosa in cystic fibrosis patients are possible targets. Therefore, IgY's included in food for human consumption may be able to prevent or cure human diseases. Keywords: IgY, Egg yolk immunoglobulin, Nutrition, Oral passive immunization, Passive immunity |
| ArticleNumber | 109 |
| Audience | Academic |
| Author | Dyck, Terry Oelkrug, Christopher Müller, Sandra Schubert, Andreas Zajac, Julia |
| Author_xml | – sequence: 1 givenname: Sandra surname: Müller fullname: Müller, Sandra organization: Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103, Leipzig, Germany – sequence: 2 givenname: Andreas surname: Schubert fullname: Schubert, Andreas organization: Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103, Leipzig, Germany – sequence: 3 givenname: Julia surname: Zajac fullname: Zajac, Julia organization: Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103, Leipzig, Germany – sequence: 4 givenname: Terry surname: Dyck fullname: Dyck, Terry organization: IgY Immune Technologies and Life Sciences Inc., Thunder Bay, Canada – sequence: 5 givenname: Christopher surname: Oelkrug fullname: Oelkrug, Christopher email: christopher.oelkrug@izi.fraunhofer.de, christopher.oelkrug@izi.fraunhofer.de organization: Fraunhofer Project Centre for Biomedical Engineering and Advanced Manufacturing, McMaster University, Hamilton, Canada. christopher.oelkrug@izi.fraunhofer.de |
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| SubjectTerms | Antibiotics Antibodies - immunology Antibodies - therapeutic use Antigens Cystic fibrosis Digestive System Diseases - immunology Digestive System Diseases - prevention & control Drug resistance in microorganisms Egg Yolk - immunology Health aspects Humans Immunoglobulins - immunology Immunoglobulins - therapeutic use Nutrition Prevention Review |
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| Title | IgY antibodies in human nutrition for disease prevention |
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