Increased Prevalence of Fractures in Congenital Adrenal Hyperplasia: A Swedish Population-based National Cohort Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 107; no. 2; pp. e475 - e486
• Main Authors: Falhammar, Henrik, Frisén, Louise, Hirschberg, Angelica Lindén, Nordenskjöld, Agneta, Almqvist, Catarina, Nordenström, Anna
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 18.01.2022
• Subjects: Adolescent; Adrenal Hyperplasia, Congenital - complications; Adrenal Hyperplasia, Congenital - diagnosis; Adrenal Hyperplasia, Congenital - genetics; Adrenal Hyperplasia, Congenital - metabolism; Adult; Bone Density - genetics; Case-Control Studies; Child; Child, Preschool; Female; Fractures, Bone - epidemiology; Fractures, Bone - genetics; Fractures, Bone - metabolism; Fractures, Bone - prevention & control; Humans; Infant; Infant, Newborn; Male; Medicin och hälsovetenskap; Middle Aged; Neonatal Screening - organization & administration; Neonatal Screening - standards; Online Only; Prevalence; Registries - statistics & numerical data; Steroid 21-Hydroxylase - genetics; Steroid 21-Hydroxylase - metabolism; Sweden - epidemiology; Young Adult; Sweden; trauma; bone mineral density; 21-hydroxylase deficiency; fall; osteoporosis

Low bone mineral density has been reported in individuals with congenital adrenal hyperplasia (CAH), but the prevalence of fractures is unclear. To study the prevalence of fractures in CAH. Patients with CAH (n = 714, all 21-hydroxylase deficiency) were compared with controls matched for sex and yea...