Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model

• Published in: Microbiome Vol. 4; no. 1; p. 26
• Main Authors: Hu, Jianzhong, Raikhel, Vincent, Gopalakrishnan, Kalpana, Fernandez-Hernandez, Heriberto, Lambertini, Luca, Manservisi, Fabiana, Falcioni, Laura, Bua, Luciano, Belpoggi, Fiorella, L Teitelbaum, Susan, Chen, Jia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.06.2016; BioMed Central
• Subjects: Adolescence; Animals; Bacteroidetes - isolation & purification; Betaproteobacteria - isolation & purification; Body Weight - drug effects; Deltaproteobacteria - isolation & purification; Environmental Exposure - adverse effects; Environmental Pollutants - pharmacology; Environmental Pollution - adverse effects; Feces - microbiology; Female; Firmicutes - isolation & purification; Gastrointestinal Microbiome - drug effects; Microbiota (Symbiotic organisms); Parabens - pharmacology; Personal care industry; Phthalic Acids - pharmacology; Postpartum Period; Rats; Rats, Sprague-Dawley; Ribosomal RNA; RNA, Ribosomal, 16S - genetics; Toiletries; Triclosan - pharmacology; Microbiota; Phthalate; Triclosan; Paraben

This proof-of-principle study examines whether postnatal, low-dose exposure to environmental chemicals modifies the composition of gut microbiome. Three chemicals that are widely used in personal care products-diethyl phthalate (DEP), methylparaben (MPB), triclosan (TCS)-and their mixture (MIX) were...