Increased O -GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome

• Published in: Frontiers in physiology Vol. 9; p. 341
• Main Authors: da Costa, Rafael M, da Silva, Josiane F, Alves, Juliano V, Dias, Thiago B, Rassi, Diane M, Garcia, Luis V, Lobato, Núbia de Souza, Tostes, Rita C
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.04.2018
• Subjects: eNOS; high-sugar diet; O-GlcNAc; Physiology; PVAT; vascular function; vascular function; eNOS; PVAT; high-sugar diet; O-GlcNAc

Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with i...